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Volumn 26, Issue 36, 2008, Pages 4758-4765

Synthetic peptide AT20 coupled to KLH elicits antibodies against a conserved conformational epitope from a major functional area of the HIV-1 matrix protein p17

Author keywords

HIV 1 matrix protein p17; Neutralizing antibodies; Synthetic peptide based vaccine

Indexed keywords

EPITOPE; KEYHOLE LIMPET HEMOCYANIN; PEPTIDE AT20; PROTEIN P17;

EID: 48649086131     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.06.082     Document Type: Article
Times cited : (24)

References (39)
  • 1
    • 4444316121 scopus 로고    scopus 로고
    • Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein
    • Staprans S.I., Barry A.P., Silvestri G., Safrit J.T., Kozyr N., Sumpter B., et al. Enhanced SIV replication and accelerated progression to AIDS in macaques primed to mount a CD4 T cell response to the SIV envelope protein. Proc Natl Acad Sci USA 101 35 (2004) 13026-13031
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.35 , pp. 13026-13031
    • Staprans, S.I.1    Barry, A.P.2    Silvestri, G.3    Safrit, J.T.4    Kozyr, N.5    Sumpter, B.6
  • 2
    • 84857788931 scopus 로고    scopus 로고
    • Vaccination and enrollment are discontinued in phase II trials of Merck's investigational HIV vaccine candidate
    • Whitehouse Station NJ and Seattle, WA
    • Vaccination and enrollment are discontinued in phase II trials of Merck's investigational HIV vaccine candidate. Press release from Merck and the HIV Vaccine Trials Network. Whitehouse Station NJ and Seattle, WA (2007)
    • (2007) Press release from Merck and the HIV Vaccine Trials Network
  • 3
    • 0022861212 scopus 로고
    • Sequence homology between acquired immunodeficiency syndrome virus envelope protein and interleukin 2
    • Reiher W.E., Blalock J.E., and Brunck T.K. Sequence homology between acquired immunodeficiency syndrome virus envelope protein and interleukin 2. Proc Natl Acad Sci USA 83 23 (1986) 9188-9192
    • (1986) Proc Natl Acad Sci USA , vol.83 , Issue.23 , pp. 9188-9192
    • Reiher, W.E.1    Blalock, J.E.2    Brunck, T.K.3
  • 4
    • 0024320275 scopus 로고
    • Investigation of immunosuppressive properties of inactivated human immunodeficiency virus and possible neutralization of this effect by some patient sera
    • Hofmann B., Langhoff E., Lindhardt B.O., Odum N., Hyldig-Nielsen J.J., Ryder L.P., et al. Investigation of immunosuppressive properties of inactivated human immunodeficiency virus and possible neutralization of this effect by some patient sera. Cell Immunol 121 2 (1989) 336-348
    • (1989) Cell Immunol , vol.121 , Issue.2 , pp. 336-348
    • Hofmann, B.1    Langhoff, E.2    Lindhardt, B.O.3    Odum, N.4    Hyldig-Nielsen, J.J.5    Ryder, L.P.6
  • 5
    • 0035852306 scopus 로고    scopus 로고
    • Protection against chronic infection and AIDS by an HIV envelope peptide-cocktail vaccine in a pathogenic SHIV-rhesus model
    • Nehete P.N., Chitta S., Hossain M.M., Hill L., Bernacky B.J., Baze W., et al. Protection against chronic infection and AIDS by an HIV envelope peptide-cocktail vaccine in a pathogenic SHIV-rhesus model. Vaccine 20 5-6 (2001) 813-825
    • (2001) Vaccine , vol.20 , Issue.5-6 , pp. 813-825
    • Nehete, P.N.1    Chitta, S.2    Hossain, M.M.3    Hill, L.4    Bernacky, B.J.5    Baze, W.6
  • 6
    • 0037159614 scopus 로고    scopus 로고
    • Synthetic AIDS vaccine by targeting HIV receptor
    • Wang C.Y., Shen M., Tam G., Fang X.D., Ye J., Shen F., et al. Synthetic AIDS vaccine by targeting HIV receptor. Vaccine 21 1-2 (2002) 89-97
    • (2002) Vaccine , vol.21 , Issue.1-2 , pp. 89-97
    • Wang, C.Y.1    Shen, M.2    Tam, G.3    Fang, X.D.4    Ye, J.5    Shen, F.6
  • 7
    • 0041856083 scopus 로고    scopus 로고
    • A novel cyclic peptide immunization strategy for preventing HIV-1/AIDS infection and progression
    • Misumi S., Endo M., Mukai R., Tachibana K., Umeda M., Honda T., et al. A novel cyclic peptide immunization strategy for preventing HIV-1/AIDS infection and progression. J Biol Chem 278 34 (2003) 32335-32343
    • (2003) J Biol Chem , vol.278 , Issue.34 , pp. 32335-32343
    • Misumi, S.1    Endo, M.2    Mukai, R.3    Tachibana, K.4    Umeda, M.5    Honda, T.6
  • 8
    • 7944227451 scopus 로고    scopus 로고
    • Preclinical studies on immunogenicity of the HIV-1 p17-based synthetic peptide AT20-KLH
    • Fiorentini S., Marini E., Bozzo L., Trainini L., Saadoune L., Avolio M., et al. Preclinical studies on immunogenicity of the HIV-1 p17-based synthetic peptide AT20-KLH. Biopolymers 76 4 (2004) 334-343
    • (2004) Biopolymers , vol.76 , Issue.4 , pp. 334-343
    • Fiorentini, S.1    Marini, E.2    Bozzo, L.3    Trainini, L.4    Saadoune, L.5    Avolio, M.6
  • 9
    • 0023244859 scopus 로고
    • Human immunodeficiency virus contains an epitope immunoreactive with thymosin alpha 1 and the 30-amino acid synthetic p17 group-specific antigen peptide HGP-30
    • Naylor P.H., Naylor C.W., Badamchian M., Wada S., Goldstein A.L., Wang S.S., et al. Human immunodeficiency virus contains an epitope immunoreactive with thymosin alpha 1 and the 30-amino acid synthetic p17 group-specific antigen peptide HGP-30. Proc Natl Acad Sci USA 84 9 (1987) 2951-2955
    • (1987) Proc Natl Acad Sci USA , vol.84 , Issue.9 , pp. 2951-2955
    • Naylor, P.H.1    Naylor, C.W.2    Badamchian, M.3    Wada, S.4    Goldstein, A.L.5    Wang, S.S.6
  • 10
    • 0024599629 scopus 로고
    • Human immunodeficiency virus type 1-neutralizing monoclonal antibodies which react with p17 core protein: characterization and epitope mapping
    • Papsidero L.D., Sheu M., and Ruscetti F.W. Human immunodeficiency virus type 1-neutralizing monoclonal antibodies which react with p17 core protein: characterization and epitope mapping. J Virol 63 1 (1989) 267-272
    • (1989) J Virol , vol.63 , Issue.1 , pp. 267-272
    • Papsidero, L.D.1    Sheu, M.2    Ruscetti, F.W.3
  • 11
    • 0031047826 scopus 로고    scopus 로고
    • A neutralizing monoclonal antibody previously mapped exclusively on human immunodeficiency virus type 1 gp41 recognizes an epitope in p17 sharing the core sequence IEEE
    • Buratti E., Tisminetzky S.G., D'Agaro P., and Baralle F.E. A neutralizing monoclonal antibody previously mapped exclusively on human immunodeficiency virus type 1 gp41 recognizes an epitope in p17 sharing the core sequence IEEE. J Virol 71 3 (1997) 2457-2462
    • (1997) J Virol , vol.71 , Issue.3 , pp. 2457-2462
    • Buratti, E.1    Tisminetzky, S.G.2    D'Agaro, P.3    Baralle, F.E.4
  • 12
    • 0028907457 scopus 로고
    • The affinity of IgG antibodies to gag p24 and p17 in HIV-1-infected patients correlates with disease progression
    • Chargelegue D., Stanley C.M., O'Toole C.M., Colvin B.T., and Steward M.W. The affinity of IgG antibodies to gag p24 and p17 in HIV-1-infected patients correlates with disease progression. Clin Exp Immunol 99 2 (1995) 175-181
    • (1995) Clin Exp Immunol , vol.99 , Issue.2 , pp. 175-181
    • Chargelegue, D.1    Stanley, C.M.2    O'Toole, C.M.3    Colvin, B.T.4    Steward, M.W.5
  • 13
    • 0030897105 scopus 로고    scopus 로고
    • Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1
    • Binley J.M., Klasse P.J., Cao Y., Jones I., Markowitz M., Ho D.D., et al. Differential regulation of the antibody responses to Gag and Env proteins of human immunodeficiency virus type 1. J Virol 71 4 (1997) 2799-2809
    • (1997) J Virol , vol.71 , Issue.4 , pp. 2799-2809
    • Binley, J.M.1    Klasse, P.J.2    Cao, Y.3    Jones, I.4    Markowitz, M.5    Ho, D.D.6
  • 15
    • 6844242335 scopus 로고    scopus 로고
    • HIV p17 enhances lymphocyte proliferation and HIV-1 replication after binding to a human serum factor
    • De Francesco M.A., Caruso A., Fallacara F., Canaris A.D., Dima F., Poiesi C., et al. HIV p17 enhances lymphocyte proliferation and HIV-1 replication after binding to a human serum factor. AIDS 12 3 (1998) 245-252
    • (1998) AIDS , vol.12 , Issue.3 , pp. 245-252
    • De Francesco, M.A.1    Caruso, A.2    Fallacara, F.3    Canaris, A.D.4    Dima, F.5    Poiesi, C.6
  • 16
    • 0037162558 scopus 로고    scopus 로고
    • HIV-1 matrix protein p17 increases the production of proinflammatory cytokines and counteracts IL-4 activity by binding to a cellular receptor
    • De Francesco M., Baronio M., Fiorentini S., Signorini C., Bonfanti C., Poiesi C., et al. HIV-1 matrix protein p17 increases the production of proinflammatory cytokines and counteracts IL-4 activity by binding to a cellular receptor. Proc Natl Acad Sci USA 99 15 (2002) 9972-9977
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.15 , pp. 9972-9977
    • De Francesco, M.1    Baronio, M.2    Fiorentini, S.3    Signorini, C.4    Bonfanti, C.5    Poiesi, C.6
  • 17
    • 0037278223 scopus 로고    scopus 로고
    • HIV-1 matrix protein p17 enhances the proliferative activity of natural killer cells and increases their ability to secrete proinflammatory cytokines
    • Vitale M., Caruso A., De Francesco M.A., Rodella L., Bozzo L., Garrafa E., et al. HIV-1 matrix protein p17 enhances the proliferative activity of natural killer cells and increases their ability to secrete proinflammatory cytokines. Br J Haematol 120 2 (2003) 337-343
    • (2003) Br J Haematol , vol.120 , Issue.2 , pp. 337-343
    • Vitale, M.1    Caruso, A.2    De Francesco, M.A.3    Rodella, L.4    Bozzo, L.5    Garrafa, E.6
  • 18
    • 38849114213 scopus 로고    scopus 로고
    • HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: role of transcriptional factor AP-1
    • Marini E., Tiberio L., Caracciolo S., Tosti G., Guzman C.A., Schiaffonati L., et al. HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: role of transcriptional factor AP-1. Cell Microbiol 10 3 (2008) 655-666
    • (2008) Cell Microbiol , vol.10 , Issue.3 , pp. 655-666
    • Marini, E.1    Tiberio, L.2    Caracciolo, S.3    Tosti, G.4    Guzman, C.A.5    Schiaffonati, L.6
  • 19
    • 41649116702 scopus 로고    scopus 로고
    • HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype
    • Fiorentini S., Riboldi E., Facchetti F., Avolio M., Fabbri M., Tosti G., et al. HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype. Proc Natl Acad Sci USA 105 10 (2008) 3867-3872
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.10 , pp. 3867-3872
    • Fiorentini, S.1    Riboldi, E.2    Facchetti, F.3    Avolio, M.4    Fabbri, M.5    Tosti, G.6
  • 20
    • 26844552845 scopus 로고    scopus 로고
    • Persistence of HIV-1 structural proteins and glycoproteins in lymph nodes of patients under highly active antiretroviral therapy
    • Popovic M., Tenner-Racz K., Pelser C., Stellbrink H.J., van Lunzen J., Lewis G., et al. Persistence of HIV-1 structural proteins and glycoproteins in lymph nodes of patients under highly active antiretroviral therapy. Proc Natl Acad Sci USA 102 41 (2005) 14807-14812
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.41 , pp. 14807-14812
    • Popovic, M.1    Tenner-Racz, K.2    Pelser, C.3    Stellbrink, H.J.4    van Lunzen, J.5    Lewis, G.6
  • 21
    • 26444444082 scopus 로고    scopus 로고
    • Retroviral matrix domains share electrostatic homology: models for membrane binding function throughout the viral life cycle
    • Murray P.S., Li Z., Wang J., Tang C.L., Honig B., and Murray D. Retroviral matrix domains share electrostatic homology: models for membrane binding function throughout the viral life cycle. Structure 13 10 (2005) 1521-1531
    • (2005) Structure , vol.13 , Issue.10 , pp. 1521-1531
    • Murray, P.S.1    Li, Z.2    Wang, J.3    Tang, C.L.4    Honig, B.5    Murray, D.6
  • 22
    • 0030747461 scopus 로고    scopus 로고
    • HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import
    • Foucjier R.A., Meyer B.E., Simon J.H., Fischer U., and Malim M.H. HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import. EMBO J 16 15 (1997) 4531-4539
    • (1997) EMBO J , vol.16 , Issue.15 , pp. 4531-4539
    • Foucjier, R.A.1    Meyer, B.E.2    Simon, J.H.3    Fischer, U.4    Malim, M.H.5
  • 23
    • 0031575524 scopus 로고    scopus 로고
    • Pleiotropic mutations in the HIV-1 matrix protein that affect diverse steps in replication
    • Casella C.R., Raffini L.J., and Panganibam A.T. Pleiotropic mutations in the HIV-1 matrix protein that affect diverse steps in replication. Virology 228 2 (1997) 294-306
    • (1997) Virology , vol.228 , Issue.2 , pp. 294-306
    • Casella, C.R.1    Raffini, L.J.2    Panganibam, A.T.3
  • 24
    • 0031980211 scopus 로고    scopus 로고
    • Role of matrix in an early post-entry step in the human immunodeficiency virus type 1 life cycle
    • Kiernan R.E., Ono A., Englund G., and Freed E.O. Role of matrix in an early post-entry step in the human immunodeficiency virus type 1 life cycle. J Virol 72 5 (1998) 4116-4126
    • (1998) J Virol , vol.72 , Issue.5 , pp. 4116-4126
    • Kiernan, R.E.1    Ono, A.2    Englund, G.3    Freed, E.O.4
  • 25
    • 0034015604 scopus 로고    scopus 로고
    • Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts
    • Nguyen D.H., and Hildreth J.E. Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts. J Virol 74 7 (2000) 3264-3272
    • (2000) J Virol , vol.74 , Issue.7 , pp. 3264-3272
    • Nguyen, D.H.1    Hildreth, J.E.2
  • 26
    • 0037384986 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 assembly and lipid rafts: Pr55 (gag) associates with membrane domains that are largely resistant to Brij98 but sensitive to Triton X-100
    • Holm K., Weclewicz K., Hewson R., and Suomalainen M. Human immunodeficiency virus type 1 assembly and lipid rafts: Pr55 (gag) associates with membrane domains that are largely resistant to Brij98 but sensitive to Triton X-100. J Virol 77 8 (2003) 4805-4817
    • (2003) J Virol , vol.77 , Issue.8 , pp. 4805-4817
    • Holm, K.1    Weclewicz, K.2    Hewson, R.3    Suomalainen, M.4
  • 27
    • 0035923525 scopus 로고    scopus 로고
    • Plasma membrane rafts play a critical role in HIV-1 assembly and release
    • Ono A., and Freed E.O. Plasma membrane rafts play a critical role in HIV-1 assembly and release. Proc Natl Acad Sci USA 98 24 (2001) 13925-13930
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.24 , pp. 13925-13930
    • Ono, A.1    Freed, E.O.2
  • 29
    • 0034853037 scopus 로고    scopus 로고
    • Lipid rafts and HIV-1: from viral entry to assembly of progeny virions
    • Ono A., Ablan S.D., Crowe S.M., and Mak J. Lipid rafts and HIV-1: from viral entry to assembly of progeny virions. J Clin Virol 22 3 (2001) 217-227
    • (2001) J Clin Virol , vol.22 , Issue.3 , pp. 217-227
    • Ono, A.1    Ablan, S.D.2    Crowe, S.M.3    Mak, J.4
  • 31
    • 33746625935 scopus 로고    scopus 로고
    • From the cover: structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly
    • Saad J.S., Miller J., Tai J., Kim A., Ghanam R.H., and Summers M.F. From the cover: structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly. Proc Natl Acad Sci USA 103 30 (2006) 11364-11369
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.30 , pp. 11364-11369
    • Saad, J.S.1    Miller, J.2    Tai, J.3    Kim, A.4    Ghanam, R.H.5    Summers, M.F.6
  • 32
    • 0027381634 scopus 로고
    • Mutations in the N-terminal region of human immunodeficiency virus type 1 matrix protein block intracellular transport of the Gag precursor
    • Yuan X., Yu X., Lee T.H., and Essex M. Mutations in the N-terminal region of human immunodeficiency virus type 1 matrix protein block intracellular transport of the Gag precursor. J Virol 67 11 (1993) 6387-6394
    • (1993) J Virol , vol.67 , Issue.11 , pp. 6387-6394
    • Yuan, X.1    Yu, X.2    Lee, T.H.3    Essex, M.4
  • 33
    • 0028355603 scopus 로고
    • Identification of human immunodeficiency virus type 1 Gag protein domain essential to membrane binding and particle assembly
    • Spearman P., Wang J.J., Vander Heyden N., and Ratner L. Identification of human immunodeficiency virus type 1 Gag protein domain essential to membrane binding and particle assembly. J Virol 68 5 (1994) 3232-3242
    • (1994) J Virol , vol.68 , Issue.5 , pp. 3232-3242
    • Spearman, P.1    Wang, J.J.2    Vander Heyden, N.3    Ratner, L.4
  • 34
    • 0025324727 scopus 로고
    • Analysis of the secondary structure of the human immunodeficiency virus (HIV) proteins p17, gp120, and gp41 by computer modeling based on neural network methods
    • Andreassen H., Bohr H., Bohr J., Brunak S., Bugge T., Cotterill R.M., et al. Analysis of the secondary structure of the human immunodeficiency virus (HIV) proteins p17, gp120, and gp41 by computer modeling based on neural network methods. J Acquir Immune Defic Syndr 3 6 (1990) 615-622
    • (1990) J Acquir Immune Defic Syndr , vol.3 , Issue.6 , pp. 615-622
    • Andreassen, H.1    Bohr, H.2    Bohr, J.3    Brunak, S.4    Bugge, T.5    Cotterill, R.M.6
  • 35
    • 0026564437 scopus 로고
    • Synthetic approaches to vaccines for infectious and autoimmune diseases
    • Sela M., and Arnon R. Synthetic approaches to vaccines for infectious and autoimmune diseases. Vaccine 10 14 (1992) 991-999
    • (1992) Vaccine , vol.10 , Issue.14 , pp. 991-999
    • Sela, M.1    Arnon, R.2
  • 36
    • 0028873216 scopus 로고
    • Antigenic peptides
    • Dyson H.J., and Wright P.E. Antigenic peptides. FASEB J 9 January (1) (1995) 37-42
    • (1995) FASEB J , vol.9 , Issue.January 1 , pp. 37-42
    • Dyson, H.J.1    Wright, P.E.2
  • 37
    • 0025321903 scopus 로고
    • Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A
    • Stanfield R.L., Fieser T.M., Lerner R.A., and Wilson I.A. Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A. Science 248 4956 (1990) 712-719
    • (1990) Science , vol.248 , Issue.4956 , pp. 712-719
    • Stanfield, R.L.1    Fieser, T.M.2    Lerner, R.A.3    Wilson, I.A.4
  • 38
    • 0025029685 scopus 로고
    • Antigenic properties and protective capacity of a cyclic peptide corresponding to site A of influenza virus haemagglutinin
    • Muller S., Plaué S., Samama J.P., Valette M., Briand J.P., and Van Regenmortel M.H. Antigenic properties and protective capacity of a cyclic peptide corresponding to site A of influenza virus haemagglutinin. Vaccine 8 4 (1990) 308-314
    • (1990) Vaccine , vol.8 , Issue.4 , pp. 308-314
    • Muller, S.1    Plaué, S.2    Samama, J.P.3    Valette, M.4    Briand, J.P.5    Van Regenmortel, M.H.6
  • 39
    • 0026087248 scopus 로고
    • Binding to native proteins by antipeptide monoclonal antibodies
    • Spangler B.D. Binding to native proteins by antipeptide monoclonal antibodies. J Immunol 146 5 (1991) 1591-1595
    • (1991) J Immunol , vol.146 , Issue.5 , pp. 1591-1595
    • Spangler, B.D.1


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