Recurrent and multiple bladder tumors show conserved expression profiles

BMC Cancer

Volumn 8, Issue , 2008, Pages

  Lindgren, David ^a   Gudjonsson, Sigurdur ^a   Jee, Kowan J ^b   Liedberg, Fredrik ^a   Aits, Sonja ^a   Andersson, Anna ^a   Chebil, Gunilla ^c   Borg, Åke ^a   Knuutila, Sakari ^b   Fioretos, Thoas ^a   Månsson, Wiking ^a   Höglund, Mattias ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF HELSINKI   (Finland)

^c HELSINGBORG HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BLADDER CANCER; CANCER CLASSIFICATION; CANCER RECURRENCE; CHROMOSOME LOSS; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENETIC DIFFERENCE; GENETIC SIMILARITY; HAPLOTYPE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MUTATIONAL ANALYSIS; BLADDER TUMOR; CANCER STAGING; CARCINOMA; CELL TRANSFORMATION; DNA MICROARRAY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; MULTIPLE CANCER; NUCLEOTIDE SEQUENCE; PATHOLOGY; POINT MUTATION; TUMOR RECURRENCE;

FGFR3 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR RECEPTOR 3; PROTEIN P53; TP53 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

CARCINOMA; CELL TRANSFORMATION, NEOPLASTIC; DNA MUTATIONAL ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASMS, MULTIPLE PRIMARY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POINT MUTATION; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 3; TUMOR SUPPRESSOR PROTEIN P53; URINARY BLADDER NEOPLASMS;

EID: 48549105755     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-183     Document Type: Article

References (23)

1. Fadl-Elmula I Chromosomal changes in uroepithelial carcinomas Cell Chromosome 2005, 4:1-5 1199610 16083510 10.1186/1475-9268-4-1
2. Höglund M Säll T Heim S Mitelman F Mandahl N Fadl-Elmula I Identification of cytogenetic subgroups and karyotypic pathways in transitional cell carcinoma Cancer Res 2001, 61:8241-8246 11719456
3. Knowles MA Identification of novel bladder tumour suppressor genes Electrophoresis 1999, 20:269-279 10.1002/ (SICI)1522-2683(19990201)20:2<269::AID-ELPS269>3.0.CO;2-7 10197433
4. Billerey C Chopin D Aubriot-Lorton MH Ricol D Gil Diez de Medina S Van Rhijn B Bralet MP Lefrere-Belda MA Lahaye JB Abbou CC Bonaventure J Zafrani ES Kwast van der T Thiery JP Radvanyi F Frequent FGFR3 mutations in papillary non-invasive bladder (pTa) tumors Am J Pathol 2001, 158:1955-1959 1891972 11395371
5. Wu XR Urothelial tumorigenesis: A tale of divergent pathways Nat Rev Cancer 2005, 5:713-725 10.1038/nrc1697 16110317
6. Fadl-Elmula I Gorunova L Mandahl N Elfving P Lundgren R Mitelman F Cytogenetic monoclonality in multifocal uroepithelial carcinomas: evidence of intraluminal tumour seeding Br J Cancer 1999, 81:6-12 10.1038/sj.bjc.6690643 10487605
7. Li M Cannizzaro LA Identical clonal origin of synchronous and metachronous low-grade, noninvasive papillary transitional cell carcinomas of the urinary tract Hum Pathol 1999, 30:1197-1200 10.1016/ S0046-8177(99)90037-0 10534167
8. Sidransky D Frost P Von Eschenbach A Oyasu R Preisinger AC Vogelstein B Clonal origin bladder cancer N Engl J Med 1992, 326:737-740 1445507
9. Hafner C Knuechel R Stoehr R Hartmann A Clonality of multifocal urothelial carcinomas: 10 years of molecular genetic studies Int J Cancer 2002, 101:1-6 10.1002/ijc.10544 12209580
10. van Tilborg AA de Vries A de Bont M Groenfeld LE Kwast van der TH Zwarthoff EC Molecular evolution of multiple recurrent cancers of the bladder Hum Mol Genet 2000, 9:2973-2980 10.1093/hmg/9.20.2973 11115841
11. Dyrskjøt L Kruhøffer M Thykjaer T Marcussen N Jensen JL Møller K Ørntoft TF Gene expression in the urinary bladder: A common carcinoma in situ gene expression signature exists disregarding histopathological classification Cancer Res 2004, 64:4040-4048 10.1158/0008-5472.CAN-03-3620 15173019
12. Modlich O Prisack HB Pitschke G Ramp U Ackermann R Bojar H Vögeli TA Grimm MO Identifying superficial, muscle-invasive, and metastasizing transitional cell carcinoma of the bladder: Use of cDNA array analysis of gene expression profiles Clin Cancer Res 2004, 15:3410-3421 10.1158/ 1078-0432.CCR-03-0134 15161696
13. Lindgren D Liedberg F Andersson A Chebil G Gudjonsson S Borg A Månsson W Fioretos T Höglund M Molecular characterization of early-stage bladder carcinomas by expression profiles, FGFR3 mutation status, and loss of 9q Oncogene 2006, 25:2685-2696 10.1038/ sj.onc.1209249 16532037
14. Heidenblad M Lindgren D Jonson T Liedberg F Veerla S Chebil G Gudjonsson S Borg Å Månsson W Höglund M Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors BMC Medical Genomics 2008, 1:3 2227947 18237450 10.1186/ 1755-8794-1-3
15. Saal LH Troein C Vallon-Christersson J Gruvberger S Borg Å Peterson C BioArray Software Environment (BASE): A platform for comprehensive management and analysis of microarray data Genome Biol 2003, 3: SOFTWARE0003 12186655 139402
16. El-Rifai W Larramendy ML Bjorkqvist AM Hemmer S Knuutila S Optimization of comparative genomic hybridization using fluorochrome conjugated to dCTP and dUTP nucleotides Lab Invest 1997, 77:699-700 9426409
17. Höglund M Bladder cancer, a two phased disease Semin Cancer Biol 2007, 17:225-232 10.1016/j.semcancer.2006.02.002 16574430
18. Höglund M On the origin of syn- and metachronous urothelial carcinomas Eur Urol 2007, 51:1185-1193 10.1016/j.eururo.2006.11.025 17123702
19. Chaturvedi V Li L Hodges S Johnston D Ro JY Logothetis C von Eschenbach AC Batsakis JG Czerniak B Superimposed histologic and genetic mapping of chromosome 17 alterations in human urinary bladder neoplasia Oncogene 1997, 14:2059-2070 10.1038/sj.onc.1201044 9160886
20. Czerniak B Chaturvedi V Li L Hodges S Johnston D Roy JY Luthra R Logothetis C Von Eschenbach AC Grossman HB Benedict WF Batsakis JG Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: Implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer Oncogene 1999, 18:1185-1196 10.1038/ sj.onc.1202385 10022124
21. Czerniak B Li L Chaturvedi V Ro JY Johnston DA Hodges S Benedict WF Genetic modeling of human urinary bladder carcinogenesis Genes Chromosomes Cancer 2000, 27:392-402 10.1002/ (SICI)1098-2264(200004)27:4<392::AID-GCC9>3.0.CO;2-N 10719370
22. Denzinger S Mohren K Knuechel R Wild PJ Burger M Wieland WF Hartmann A Stoehr R Improved clonality analysis of multifocal bladder tumors by combination of histopathologic organ mapping, loss of heterozygosity, fluorescence in situ hybridization, and p53 analyses Hum Pathol 2006, 37:143-151 10.1016/j.humpath.2005.10.014 16426913
23. Simon R Eltze E Schäfer KL Bürger H Semjonow A Hertle L Dockhorn-Dworniczak B Terpe HJ Böcker W Cytogenetic analysis of multifocal bladder cancer supports a monoclonal origin and intraepithelial spread of tumor cells Cancer Res 2001, 61:355-62 11196186