Effects of L-isoleucine and L-valine on hot flushes and serum homocysteine: A randomized controlled trial

Obstetrics and Gynecology

Volumn 112, Issue 1, 2008, Pages 109-115

  Guttuso Jr , Thomas ^a   McDermott, Michael P ^b   Su, Haiyan ^b   Kieburtz, Karl ^b  

^a UNIVERSITY AT BUFFALO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BIOTIN; EQUATE MULTIVITAMIN; FOLIC ACID; GABAPENTIN; HOMOCYSTEINE; ISOLEUCINE; MECOBALAMIN; MULTIVITAMIN; PLACEBO; PYRIDOXINE; UNCLASSIFIED DRUG; VALINE; VITAMIN B COMPLEX; CALCIUM CHANNEL BLOCKING AGENT;

ADULT; AMINO ACID BLOOD LEVEL; ARTHRALGIA; ARTICLE; BLOOD ANALYSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DRUG CAPSULE; DRUG EFFECT; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; EDEMA; FEMALE; HERPES ZOSTER; HOT FLUSH; HUMAN; INFECTION; MAJOR CLINICAL STUDY; MYALGIA; NAUSEA; OUTCOME ASSESSMENT; OUTCOME VARIABLE; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; POSTMENOPAUSE; PRIORITY JOURNAL; PROBABILITY; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; STROKE; TREATMENT DURATION; BLOOD; DIET SUPPLEMENTATION; DRUG COMBINATION; HOSPITALIZATION; MIDDLE AGED;

CALCIUM CHANNEL BLOCKERS; DIETARY SUPPLEMENTS; DRUG THERAPY, COMBINATION; FEMALE; HOMOCYSTEINE; HOT FLASHES; HUMANS; ISOLEUCINE; MIDDLE AGED; POSTMENOPAUSE; SEVERITY OF ILLNESS INDEX; VALINE;

EID: 48549105085     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1097/AOG.0b013e31817d53b6     Document Type: Article

References (25)

1. Hammar M, Berg G, Fahraeus L, Larsson-Cohn U. Climacteric symptoms in an unselected sample of Swedish women. Maturitas 1984;6:345-50.
2. Blumel JE, Castelo-Branco C, Binfa L, Gramegna G, Tacla X, Aracena B, et al. Quality of life after the menopause: a population study. Maturitas 2000;34:17-23.
3. RossouwJE, Anderson GL, Prentice RL, LaCroix AZ, Kooper-berg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-33.
4. Rossouw JE, Prentice RL, Manson JE, Wu L, Barad D, Barnabei VM, et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause [published erratum appears in JAMA 2008;288:1426], JAMA 2007;297:1465-77.
5. Ockene JK, Barad DH, Cochrane BB, Larson JC, Gass M, Wassertheil-Smoller et al. Symptom experience after discontinuing use of estrogen plus progestin. JAMA 2005;294:183-93.
6. Guttuso T Kurlan R, McDermott MP, Kieburtz K. Gabapen-tin's effects on hot flashes in postmenopausal women: a randomized controlled trial. Obstet Gynecol 2003;101:337-45.
7. Reddy SY, Warner H, Guttuso T Messing S, DiGrazio W, Thornburg L, et al. Gabapentin, estrogen, and placebo for treating hot flushes: a randomized controlled trial. Obstet Gynecol 2006;108:41-8.
8. Speroff L, Gass M, Constantine G, Olivier S, Study 315 Investigators. Efficacy and tolerability of desvenlafaxine succinate treatment for menopausal vasomotor symptoms: a randomized controlled trial. Obstet Gynecol 2008;111:77-87.
9. Thurlow RJ, Brown JP, Gee NS, Hill DR, Woodruff GN. [3H]gabapentin may label a system-L-like neutral amino acid carrier in brain. Eur J Pharmacol 1993;247:341-5.
10. Clarke R, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, et al. Hyperhomocysteinemia: an independent risk factor for vascular disease. N Engl J Med 1991;324:1149-55.
11. van der Griend R, Biesma DH, BangaJD. Postmethionine-load homocysteine determination for the diagnosis hyperhomocys-teinaemia and efficacy of homocysteine lowering treatment regimens. Vasc Med 2002;7:29-33.
12. Ditscheid B, Fiinfstiick R, Busch M, Schubert R, Gerth J, Jahreis G Effect of L-methionine supplementation on plasma homocysteine and other free amino acids: a placebo-controlled double-blind cross-over study. Eur J Clin Nutr 2005;59: 768-75.
13. Narasimhan P, Sklar R, Murrell M, Swanson RA, Sharp FR Methylmalonyl-CoA mutase induction by cerebral ischemia and neurotoxicity of the mitochondrial toxin methylmalonic acid.J Neurosci 1996;16:7336-46.
14. Gompertz D, Jones JH, KnowlesJP. Metabolic precursors of methylmalonic acid in vitamin B12 deficiency. Clin Chim Acta 1967;18:197-204.
15. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research. Guidance for industry: estrogen and estrogen/pro-gestin drug products to treat vasomotor symptoms and vulvar and vaginal atrophy symptoms- recommendations for clinical evaluation. Available at: http://www.fda.gov/cder/guidance/ 5412dft.pdf. Accessed July 6, 2007.
16. Buysse DJ, Reynolds CF Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989;28: 193-213.
17. Evans ML, Pritts E, Vittinghoff E, McClish K, Morgan KS, Jaffe RB. Management of postmenopausal hot flushes with venlafaxine hydrochloride: a randomized, controlled trial. Obstet Gynecol 2005;105:161-6.
18. Barentsen R, van de Weijer PH, van Gend S, Foekema H. Climacteric symptoms in a representative Dutch population sample as measured with the Greene Climacteric Scale. Matu-ritas 2001;38:123-8.
19. Little RJA, Rubin DB. Statistical analysis with missing data. 2nd ed. Hoboken (NJ): John Wiley and Sons, 2002.
20. Hettmansperger T.. Statistical inference based on ranks. New York (NY): John Wiley and Sons, 1984.
21. Lerner J, Larimore DL. Comparative aspects of the apparent Michaelis constant for neutral amino acid transport in several animal tissues. Comp Biochem Physiol B 1986;84:235-48.
22. Smith QR, Momma S, Aoyagi M, Rapoport SI. Kinetics of neutral amino acid transport across the blood-brain barrier. J Neurochem 1987;49:1651-8.
23. Bønaa KH, Njølstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 2006; 354:1578-88.
24. Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, et al. Homocysteine lowering with folic acid and B vitamins in vascular disease [published erratum appears in N EnglJ Med 2006;355:746]. N EnglJ Med 2006;354:1567-77.
25. TooleJF, Malinow MR, Chambless LE, SpenceJD, Pettigrew LC, Howard VJ, et al. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 2004;291:565-75.