Loss of the transmembrane but not the soluble kit ligand isoform increases testicular germ cell tumor susceptibility in mice

Cancer Research

Volumn 68, Issue 13, 2008, Pages 5193-5197

  Heaney, Jason D ^a   Lam, Man Yee J ^a   Michelson, Megan V ^a   Nadeau, Joseph H ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; STEM CELL FACTOR; ISOPROTEIN; MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; EMBRYO; GENE DELETION; GENE LOCUS; GENE MUTATION; GENETIC SUSCEPTIBILITY; GERM CELL TUMOR; HETEROZYGOSITY; INCIDENCE; MALE; MOUSE; NONHUMAN; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; TESTIS TUMOR; ANIMAL; BLOOD; EMBRYO (ANATOMY); FEMALE; GENE DOSAGE; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOSITY LOSS; HUMAN; INHERITANCE; MOLECULAR GENETICS; NEOPLASM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PREGNANCY; PREVALENCE; SOLUBILITY; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; EMBRYO, MAMMALIAN; FEMALE; GENE DOSAGE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INHERITANCE PATTERNS; LOSS OF HETEROZYGOSITY; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; NEOPLASMS, GERM CELL AND EMBRYONAL; PREGNANCY; PREVALENCE; PROTEIN ISOFORMS; SOLUBILITY; STEM CELL FACTOR; TESTICULAR NEOPLASMS;

EID: 48549093520     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0779     Document Type: Article

References (49)

1. Bishop TD, Wing A. Candidate regions for testicular cancer susceptibility genes. APMIS Suppl 1998;106:64-72.
2. Heimdal K, Olsson H, Tretli S, Fossa SD, Borresen AL, Bishop DT. A segregation analysis of testicular cancer based on Norwegian and Swedish families. Br J Cancer 1997;75:1084-7.
3. Rapley EA, Crockford GP, Teare D, et al. Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours. Nat Genet 2000;24:197-200.
4. Crockford GP, Linger R, Hockley S, et al. Genome-wide linkage screen for testicular germ cell tumour susceptibility loci. Hum Mol Genet 2006;15:443-51.
5. Nathanson KL, Kanetsky PA, Hawes R, et al. The Y deletion gr/gr and susceptibility to testicular germ cell tumor. Am J Hum Genet 2005;77:1034-43.
6. Stevens LC. The biology of teratomas. Adv Morphog 1967;6:1-31.
7. Stevens LC. Development of resistance to teratocarcinogenesis by primordial germ cells in mice. J Natl Cancer Inst 1966;37:859-67.
8. Stevens LC. Origin of testicular teratomas from primordial germ cells in mice. J Natl Cancer Inst 1967;38:549-52.
9. Stevens LC, Mackensen JA. Genetic and environmental influences on teratocarcinogenesis in mice. J Natl Cancer Inst 1961;27:443-53.
10. Lam MY, Nadeau JH. Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice. APMIS 2003;111:184-90.
11. Matin A, Nadeau JH. Sensitized polygenic trait analysis. Trends Genet 2001;17:727-31.
12. Lam MY, Youngren KK, Nadeau JH. Enhancers and suppressors of testicular cancer susceptibility in single-and double-mutant mice. Genetics 2004;166:925-33.
13. Lam MY, Heaney JD, Youngren KK, Kawasoe JH, Nadeau JH. Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors. Hum Mol Genet 2007;16:2233-40.
14. Youngren KK, Coveney D, Peng X, et al. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature 2005;435:360-4.
15. Silver WK. The coat color of mice. New York: Springer-Verlag; 1979.
16. Anderson DM, Lyman SD, Baird A, et al. Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. Cell 1990;63:235-43.
17. Geissler EN, Ryan MA, Housman DE. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 1988;55:185-92.
18. Bedell MA, Cleveland LS, O'Sullivan TN, Copeland NG, Jenkins NA. Deletion and interallelic complementation analysis of Steel mutant mice. Genetics 1996;142:935-44.
19. Nocka K, Tan JC, Chiu E, et al. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. EMBO J 1990;9:1805-13.
20. Roskoski R, Jr. Signaling by Kit protein-tyrosine kinase-the stem cell factor receptor. Biochem Biophys Res Commun 2005;337:1-13.
21. Runyan C, Schaible K, Molyneaux K, Wang Z, Levin L, Wylie C. Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration. Development 2006;133:4861-9.
22. Brannan CI, Lyman SD, Williams DE, et al. Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains. Proc Natl Acad Sci U S A 1991;88:4671-4.
23. Flanagan JG, Chan DC, Leder P. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell 1991;64:1025-35.
24. Schaible RH. Notes on mutants. Mouse News Lett 1961;24:38.
25. Mahakali ZA, Hudson FP, III, Bedell MA. Analysis of hypomorphic KitlSl mutants suggests different requirements for KITL in proliferation and migration of mouse primordial germ cells. Biol Reprod 2005;73:639-47.
26. Rajaraman S, Davis WS, Mahakali-Zama A, Evans HK, Russell LB, Bedell MA. An allelic series of mutations in the kit ligand gene of mice. I. Identification of point mutations in seven ethylnitrosourea-induced Kitl(Steel) alleles. Genetics 2002;162:331-40.
27. Frazer KA, Pachter L, Poliakov A, Rubin EM, Dubchak I. VISTA: computational tools for comparative genomics. Nucleic Acids Res 2004;32:W273-279.
28. Kuhn RM, Karolchik D, Zweig AS, et al. The UCSC genome browser database: update 2007. Nucleic Acids Res 2007;35:D668-673.
29. Gillis AJ, Stoop HJ, Hersmus R, et al. High-throughput microRNAome analysis in human germ cell tumours. J Pathol 2007;213:319-28.
30. Farini D, La SG, Tedesco M, De FM. Chemoattractant action and molecular signaling pathways of Kit ligand on mouse primordial germ cells. Dev Biol 2007;306:572-83.
31. McCoshen JA, McCallion DJ. A study of the primordial germ cells during their migratory phase in Steel mutant mice. Experientia 1975;31:589-90.
32. Wehrle-Haller B, Weston JA. Soluble and cell-bound forms of steel factor activity play distinct roles in melanocyte precursor dispersal and survival on the lateral neural crest migration pathway. Development 1995;121:731-42.
33. Vincent S, Segretain D, Nishikawa S, et al. Stage-specific expression of the Kit receptor and its ligand (KL) during male gametogenesis in the mouse: a Kit-KL interaction critical for meiosis. Development 1998;125:4585-93.
34. Guerif F, Cadoret V, Rahal-Perola V, et al. Apoptosis, onset and maintenance of spermatogenesis: evidence for the involvement of Kit in Kit-haplodeficient mice. Biol Reprod 2002;67:70-9.
35. Buehr M, McLaren A, Bartley A, Darling S. Proliferation and migration of primordial germ cells in We/We mouse embryos. Dev Dyn 1993;198:182-9.
36. Godin I, Wylie C, Heasman J. Genital ridges exert long-range effects on mouse primordial germ cell numbers and direction of migration in culture. Development 1990;108:357-63.
37. De Felici M, Di Carlo A, Pesce M. Role of stem cell factor in somatic-germ cell interactions during prenatal oogenesis. Zygote 1996;4:349-51.
38. Matsui Y, Zsebo KM, Hogan BL. Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. Nature 1990;347:667-9.
39. Zamboni L, Upadhyay S. Germ cell differentiation in mouse adrenal glands. J Exp Zool 1983;228:173-93.
40. McLaren A. Meiosis and differentiation of mouse germ cells. Symp Soc Exp Biol 1984;38:7-23.
41. Voorhoeve PM, le SC, Schrier M, et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006; 124:1169-81.
42. Goddard NC, McIntyre A, Summersgill B, Gilbert D, Kitazawa S, Shipley J. KIT and RAS signalling pathways in testicular germ cell tumours: new data and a review of the literature. Int J Androl 2007;30:337-48.
43. Looijenga LH, de LH, van OM, et al. Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ-cell tumors. Cancer Res 2003;63:7674-8.
44. Biermann K, Goke F, Nettersheim D, et al. c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma. J Pathol 2007;213:311-8.
45. McIntyre A, Summersgill B, Grygalewicz B, et al. Amplification and overexpression of the KIT gene is associated with progression in the seminoma subtype of testicular germ cell tumors of adolescents and adults. Cancer Res 2005;65:8085-9.
46. Bair E, Tibshirani R. Semi-supervised methods to predict patient survival from gene expression data. PLoS Biol 2004;2:E108.
47. Li Y, Hashimoto Y, Agadir A, Kagechika H, Zhang X. Identification of a novel class of retinoic acid receptor h-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J Biol Chem 1999;274:15360-6.
48. Matsumoto A, Mizukami H, Mizuno S, et al. β-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages. Biochem Pharmacol 2007;74:256-64.
49. Oosterhuis JW, Looijenga LH. Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 2005;5:210-22.