A mathematical model for the effects of HER2 overexpression on cell proliferation in breast cancer

Bulletin of Mathematical Biology

Volumn 70, Issue 6, 2008, Pages 1707-1729

  Eladdadi, Amina ^a   Isaacson, David ^a  

^a Rensselaer Polytechnic Institute   (United States)

Author keywords

Cell proliferation; HER2; Mathematical modeling; Receptor modeling

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2;

ALGORITHM; ARTICLE; BIOLOGICAL MODEL; BREAST TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; KINETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ALGORITHMS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTER SIMULATION; EPIDERMAL GROWTH FACTOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KINETICS; MODELS, BIOLOGICAL; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

EID: 48449096621     PISSN: 00928240     EISSN: 15229602     Source Type: Journal    
DOI: 10.1007/s11538-008-9315-4     Document Type: Article

References (35)

1. I. Alroy Y. Yarden 1997 The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions FEBS Lett. 410 83 86
2. P.J. Brennan 2000 HER2/neu: mechanisms of dimerization/oligomerization Oncogene 19 6093 6101
3. K.L. Carraway III L.C. Cantley 1994 A Neu acquaintance for ErbB3 and ErbB4: a role for receptor heterodimerization in growth signaling Cell 78 5 8
4. G.M. Clark W.L. McGuire 1991 Follow-up study of HER-2/neu amplification in primary breast cancer Cancer Res. 51 944 948
5. P.P. Difiore J.H. Pierce M.H. Kraus O. Segatto C.R. King S.A. Aaronson 1987 ErbB-2 is a potent oncogene when overexpressed in NIH 3T3 cells Science 237 178 182
6. D. Graus-Porta 1997 ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling EMBO J. 16 1647 55
7. R.A. Harris T.J. Eichholtz I.D. Hiles M.J. Page M.J. O'Hare 1999 New model of ErbB-2 oeverexpression in human mammary luminal epithelial cells Int. J. Cancer 80 477 484
8. D. Hart E. Shochat Z. Agur 1998 The growth law of primary breast cancer tumors as inferred from mammography screening trials Br. J. Cancer 78 3 382 387
9. B. Hendriks L.K. Opresko H.S. Wiley D.A. Lauffenburger 2003 Quantitative analysis of HER2-mediated effects on HER2 and EGFR endocytosis: distribution of homo- and hetero-dimers depends on relative HER2 levels J. Biol. Chem. 278 23343 23351
10. B. Hendriks H.S. Wiley D.A. Lauffenburger 2003 HER2-mediated effects on EGFR endosomal sorting: analysis of biophyical mechanisms Biophys. J. 85 2732 2745
11. B.S. Hendriks G. Orr A. Wells H.S. Wiley D.A. Lauffenburger 2005 Parsing ERK activation reveals quantitatively equivalent contributions from EGFR and HER2 in human mammary epithelial cells J. Biol. Chem. 280 6157 6169
12. N.E. Hynes H.A. Lane 2005 ERBB receptors and cancer: the complexity of targeted inhibitors Nat. Rev. Cancer 5 341 354
13. N.E. Hynes K. Horsch M.A. Olayioye A. Badache 2001 The ErbB receptor tyrosine family as signal integrators Endocr. Relat. Cancer 8 151 159
14. D. Karunagaran E. Tzahar R.R. Berrli X. Chen D. Graus-Porta 1996 Common auxiliary subunit of NDF and EGF receptors: implications for breast cancer EMBO J. 15 254 264
15. Keshet, L.E., 1988. Mathematical Models in Biology, 1st edn. McGraw-Hill, New York.
16. D. Knauer H. Wiley D. Cunningham 1984 Relationship between epidermal growth factor receptor occupancy and mitogenic response. Quantitative analysis using a steady state model system J. Biol. Chem. 259 5623 5631
17. J. Kurebayashi 2001 Biological and clinical significance of HER2 overexpression in breast cancer Breast Cancer 8 45 51
18. Lauffenburger, D.A., Linderman, J., 1996. Receptors: Models for Binding, Trafficking, and Signaling. Oxford University Press, Oxford.
19. H.C. Maguire Jr. M.I. Greene 1989 The neu (c-erbB-2) oncogene Semin. Oncol. 16 148 155
20. S. Menard E. Tagliabue M. Campligio S. Pupa 2000 Role of HER2 gene overexpression in breast carcinoma J. Cell. Phys. 182 150 162
21. J. Monod 1949 The growth of bacterial cultures Ann. Rev. Microbiol. 3 371 394
22. D.J. Riese D.F. Stern 1998 Specificity within the EGF family/ErbB receptor family signaling network Bioessays 20 41 48
23. Robert, N., Leyland-Jones, B., Asmar, L., Belt, R., Ilegbodu, D., Loesch, D., Raju, R., Valentine, E., Sayre, R., Albain, K., Cobleigh, M., McCullough, C., Fuchs, L., Slamon, D., 2002. Phase III comparative study of trastuzumab and paclitaxel with and without carboplatin in patients with HER-2/neu positive advanced breast cancer. Program and Abstracts of the 25th Annual San Antonio Breast Cancer Symposium, December 11-14, 2002, San Antonio, Texas. Abstract 35.
24. D.S. Salomon R. Brandt F. Ciardiello 1995 Epidermal growth factor-related peptides and their receptors in human malignancies Crit. Rev. Oncol. Hematol. 19 183 232
25. D.J. Slamon G.M. Clark S.G. Wong 1987 Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene Science 235 177 182
26. D. Slamon W. Godolphin L. Jones 1989 Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer Science 244 707 712
27. M.R. Stampfer J.C. Bartley 1985 Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene Proc. Natl. Acad. Sci. USA 82 2394 2398
28. C. Starbuck S.H. Wiley D.A. Lauffenburger 1990 Epidermal growth factor binding and trafficking dynamics in fibroblasts: relationship to cell proliferation Chem. Eng. Sci. 45 2367 2373
29. J.F. Timms S.L. White M.J. O'Hare M.D. Waterfield 2002 Effects of ErbB-2 overexpression on mitogenic signalling and cell cycle progression in human breast luminal epithelial cells Oncogene 21 43 6573 86
30. E. Tzahar 1996 A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor Mol. Cell. Biol. 16 5276 87
31. A. Ullrich J. Schlessinger 1990 Signal transduction by receptors with tyrosine kinase activity Cell 61 203 12
32. H.S. Wiley D.D. Cunningham 1981 A steady-state model for analyzing the cellular-binding, internalization, and degradation of polypeptide ligands Cell 25 2 433 440
33. H.S. Wiley S.Y. Shvartsman D.A. Lauffenburger 2003 Computational modeling of the EGF-receptor system: a paradigm for systems biology Trends Cell. Biol. 13 43 50
34. A.C. Wilson E.E. Cajulis L.J. Green M.T. Olsen A.Y. Chung A.M. Damore J. Dering J.F. Calzone J.D. Slamon 2005 HER-2 overexpression differentially alters transforming growth factor-β responses in luminal versus mesenchymal human breast cancer cells Breast Cancer Res. 7 1058 1079
35. Y. Yarden M.X. Sliwkowski 2001 Untangling the ErbB signalling network Nat. Rev. Mol. Cell. Biol. 2 127 137