Nonclinical pharmacokinetics of BMS-292655, a water-soluble prodrug of the antifungal ravuconazole

Biopharmaceutics and Drug Disposition

Volumn 29, Issue 5, 2008, Pages 270-279

  Knipe, Jay O ^a   Mosure, Kathleen W ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Antifungal; Nonclinical; Pharmacokinetics; Prodrug

Indexed keywords

ALKALINE PHOSPHATASE; ANTIFUNGAL AGENT; BENZOIC ACID [3 [(PHOSPHONOOXY)METHYL] 1 [[ 2 [ 4 (4 CYANOPHENYL) 2 THIAZOLYL] 1 (2,4 DIFLUOROPHENYL) 1 (1H 1,2,4 TRIAZOL 1 YL)METHYL]PROPOXY]METHYL] ESTER; BMS 292655; ESTERASE; RAVUCONAZOLE;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG PROTEIN BINDING; DRUG STABILITY; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; INCUBATION TIME; LIVER; LIVER HOMOGENATE; MAXIMUM PLASMA CONCENTRATION; MONKEY; NONHUMAN; RAT; SPECIES DIFFERENCE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTIFUNGAL AGENTS; BLOOD PROTEINS; DOGS; HUMANS; HYDROLYSIS; MACACA FASCICULARIS; MALE; PRODRUGS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; THIAZOLES; TRIAZOLES;

EID: 48449093234     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.612     Document Type: Article

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