Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat

Journal of Negative Results in BioMedicine

Volumn 7, Issue 1, 2008, Pages

  Bielefeld, Eric C ^a   Coling, Donald ^a   Chen, Guang Di ^a   Henderson, Donald ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVACECARNINE; ACETYLCARNITINE;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY CORTEX; AUDITORY THRESHOLD; BIOENERGY; CONTROLLED STUDY; DRUG MEGADOSE; FEEDING; FISCHER 344 RAT; HAIR CELL; HEARING LOSS; MALE; MITOCHONDRION; MULTIPLE DRUG DOSE; NONHUMAN; RAT; ANIMAL; DOSE RESPONSE; DRUG EFFECT; EVOKED BRAIN STEM AUDITORY RESPONSE; PATHOPHYSIOLOGY;

ACETYLCARNITINE; AGING; ANIMALS; AUDITORY THRESHOLD; DOSE-RESPONSE RELATIONSHIP, DRUG; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HEARING LOSS; MALE; RATS; RATS, INBRED F344;

EID: 48449091374     PISSN: None     EISSN: 14775751     Source Type: Journal    
DOI: 10.1186/1477-5751-7-4     Document Type: Article

References (14)

1. History of the Fischer 344 rat. GN Rao GA Boorman, Pathology of the Fischer rat: Reference and Atlas San Diego, CA: Academic Press, Inc, Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, 1990 5 8
2. Age-related changes in the auditory physiology of the Fischer 344 rat. EC Bielefeld D Coling GD Chen MN Li C Tanaka D Henderson, Abstract in the 31st Midwinter Research Meeting of the Association for Research in Otolaryngology, Phoenix, AZ, Abstract #357 2008
3. Oxidative stress in aging in the C57B16/J mouse cochlea. H Staecker QY Zheng TR Van De Water, Acta Otolaryngol 2001 121 6 666 672 10.1080/ 00016480152583593 11678164
4. Oxidative imbalance in the aging inner ear. H Jiang AE Talaska J Schacht SH Sha, Neurobiol Aging 2007 28 10 1605 1612 16920227 10.1016/j.neurobiolaging. 2006.06.025
5. Age-related hearing loss in CD/1 mice is associated to ROS formation and HIF target proteins up-regulation in the cochlea. C Riva E Donadieu J Magnan JP Lavieille, Exp Gerontol 2007 42 4 327 336 10.1016/j.exger.2006.10.014 17141999
6. Biologic activity of mitochondrial metabolites on aging and age-related hearing loss. MD Seidman MJ Khan U Bai N Shirwany WS Quirk, Am J Otol 2000 21 2 161 167 10.1016/S0196-0709(00)80003-4 10733178
7. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. T Yamasoba S Someya C Yamada R Weindruch TA Prolla M Tanokura, Hear Res 2007 226 1-2 185 193 10.1016/j.heares.2006.06.004 16870370
8. Prevalence of hearing loss in older adults in Beaver Dam, Wisconsin. The Epidemiology of Hearing Loss Study. KJ Cruickshanks TL Wiley TS Tweed BE Klein R Klein JA Mares-Perlman DM Nondahl, Am J Epidemiol 1998 148 9 879 886 9801018
9. Hearing in the elderly: the Framingham cohort, 1983-1985. Part I. Basic audiometric test results. GA Gates JC Cooper Jr WB Kannel NJ Miller, Ear Hear 1990 11 4 247 256 10.1097/00003446-199008000-00001 2210098
10. Effects of dietary restriction and antioxidants on presbyacusis. MD Seidman, Laryngoscope 2000 110 5 Pt 1 727 738 10.1097/00005537-200005000-00003 10807352
11. Effects of antioxidants on the aging inner ear. T Le EM Keithley, Hear Res 2007 226 1-2 194 202 10.1016/j.heares.2006.04.003 16843623
12. Candidate's thesis: enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss. RD Kopke JK Coleman J Liu KC Campbell RH Riffenburgh, Laryngoscope 2002 112 9 1515 1532 10.1097/00005537-200209000-00001 12352659
13. Prevention of impulse noise-induced hearing loss with antioxidants. R Kopke E Bielefeld J Liu J Zheng R Jackson D Henderson JK Coleman, Acta Otolaryngol 2005 125 3 235 243 10.1080/00016480410023038 15966690
14. Pharmacological rescue of noise induced hearing loss using N-acetylcysteine and acetyl-L-carnitine. JK Coleman RD Kopke J Liu X Ge EA Harper GE Jones TL Carter RL Jackson, Hear Res 2007 226 1-2 104 113 10.1016/j.heares.2006.08.008 17023129