CTLA-4 recombinant protein genetically fused to canine Fcε receptor Iα enhances allergen specific lymphocyte responses in experimentally sensitized dogs

Journal of Veterinary Medical Science

Volumn 66, Issue 6, 2004, Pages 611-617

  Yasunaga, Sho ^a   Tsukui, Toshihiro ^b   Masuda, Kenichi ^a   Ohno, Koichi ^a   Tsujimoto, Hajime ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b ZENYAKU KOGYO CO LTD   (Japan)

Author keywords

Allergic disease; Canine; Co stimulatory molecule; DNA immunization; Immunotherapy

Indexed keywords

CANIS FAMILIARIS;

ABATACEPT; ALLERGEN; ANTIBODY CONJUGATE; HYBRID PROTEIN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR;

ANIMAL; ANIMAL DISEASE; ANTIGEN ANTIBODY COMPLEX; ANTIGEN PRESENTING CELL; ARTICLE; CELL STRAIN COS1; DOG; DOG DISEASE; GENETICS; HYPERSENSITIVITY; IMMUNIZATION; IMMUNOLOGY; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; MONOCYTE; POLLEN; T LYMPHOCYTE; WESTERN BLOTTING;

ALLERGENS; ANIMALS; ANTIGEN-ANTIBODY COMPLEX; ANTIGEN-PRESENTING CELLS; BLOTTING, WESTERN; COS CELLS; DOG DISEASES; DOGS; HYPERSENSITIVITY; IMMUNIZATION; IMMUNOCONJUGATES; IMMUNOGLOBULIN E; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; MONOCYTES; POLLEN; RECEPTORS, IGE; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES;

EID: 4844231472     PISSN: 09167250     EISSN: None     Source Type: Journal    
DOI: 10.1292/jvms.66.611     Document Type: Article

References (22)

1. Azuma, M., Yssel, H., Phillips, J.H., Spits, H. and Lanier, L.L. 1993. Functional expression of B7/BB1 on activated T lymphocytes. J. Exp. Med. 177: 845-850.
2. Boyle, J. S., Brady, J. L. and Lew, A. M. 1998. Enhanced response to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction. Nature (Lond.) 392: 408-411.
3. Chambers,C. A. and Allison, J. P. 1997. Co-stimulation in T cell responses. Curr. Opin. Immunol. 9: 396-404.
4. Deliyannis, G., Boyle, J. S., Brady, J. L., Brown, L. E. and Lew, A. M. 2000. A fusion DNA vaccine that targets antigen-presenting cells increases protection from viral challenge. Proc. Natl. Acad. Sci. U.S.A. 97: 6676-6680.
5. Ebner, C., Siemann, U., Bohle, B., Willheim, M., Wiedermann, U., Schenk, S., Klotz, F., Ebner, H., Kraft, D. and Scheiner, O. 1997. Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen. Clin. Exp. Allergy 27: 1007-1015.
6. Freeman, G. J., Gribben, J. G., Boussiotis, V. A., Ng, J. W., Restivo, V. A., Jr, Lombard, L. A., Gray G. S. and Nadler, L. M. 1993. Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262: 909-911.
7. Furin, M. J., Norman, P. S., Creticos, P. S., Proud, D., Kagey-Sobotka, A., Lichtenstein, L. M. and Naclerio, R. M. 1991. Immunotherapy decreases antigen-induced eosinophil cell migration into the nasal cavity. J. Allergy Clin. Immunol. 88: 27-32.
8. Greene, J. L., Leytze, G. M., Emswiler, J., Peach, R., Bajorath, J., Cosand, W. and Linsley, P. S. 1996. Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions. J. Biol. Chem. 271: 26762-26771.
9. Huang, T.-H., Wu, P.-Y., Lee, C.-N., Huang, H.-I, Hsieh, S.-L., Kung, J. and Tao, M.-H. 2000. Enhanced antitumor immunity by fusion of CTLA-4 to a self tumor antigen. Blood 96: 3663-3670.
10. Jutel, M., Pichler, W. J., Skrbic, D., Urwyler, A., Dahinden, C. and Muller, U. R. 1995. Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. J. Immunol. 154: 4187-4194.
11. Masuda, K., Sakaguchi, M., Saito, S., De Boer, D.J., Fujiwara, S., Kurata, K., Yamashita, K., Hasegawa, A., Ohno, K. and Tsujimoto, H. 2000. In vivo and In vitro tests showing sensitization to Japanese cedar (Cryptomeria japonica) pollen allergen in atopic dogs. J. Vet. Med. Sci. 62: 995-1000.
12. Niwa, H., Yamamura, K. and Miyazaki, J. 1991. Efficient selection for high-expression transfectant with a novel eukaryotic vector. Gene 108: 193-200.
13. Oberwalleney, G., Henz, B.M. and Worm, M. 2000. Expression and functional role of co-stimulatory molecules in CD40+IL-4-stimulated B cells from atopic and non-atopic donors. Acta. Derm. Venereol. 80: 287-291.
14. Ott, V. L. and Cambier, J. C. 2000. Activating and inhibitory signaling in mast cells: New opportunities for therapeutic intervention? J. Allergy Clin. Immunol. 106: 429-440.
15. Rocklin, R. E., Scheffer, A. L., Greineder, D. K. and Melmon, K. I. 1980. Generation of antigen-specific suppressor cells during allergy desensitization. New. Engl. J. Med. 302: 1213-1219.
16. Schuller, E., Teichmann, B., Haberstok, J., Moderer, M., Bieber, Th. and Wollenberg, A. 2001. In situ expression of the costimulatory molecules CD80 and CD86 on Langerhans cells and inflammatory dendritic epidermal cells (IDEC) in atopic dermatitis. Arch. Dermatol. Res. 293: 448-454.
17. van Hage-Hamsten, M. and Valenta, R. 2002. Specific immunotherapy-the induction of new IgE-specificities? Allergy 57: 375-378.
18. + T cells by inhibiting serum IgE-facilitated allergen presentation. J. Immunol. 163: 2944-2952.
19. Yamashita, K., Masuda, K., Sakaguchi, M., Odagiri, T., Nakao, Y., Yamaki, M., Hasegawa, A., Matsuo, Y., De Boer, D. J., Ohno, K. and Tsujimoto, H. 2000. Experimental sensitization with Japanese cedar pollen in dogs. J. Vet. Med. Sci. 62: 1223-1225.
20. Yasueda, H., Yui, Y., Shimizu, T. and Shida, T. 1983. Isolation and partial characterization of the major allergen from Japanese cedar (Cryptomeria japonica) pollen. J. Allergy Clin. Immunol. 71: 77-86.
21. Yasunaga, S., Kurata, K., Masuda, K., Ohno, K. and Tsujimoto, H. 2002. Expression Analysis of CD80 and CD86 Co-stimulatory Molecules in Dogs with Atopic Dermatitis after Receiving Immunotherapy. J. Vet. Med. Sci. (in submission)
22. Zur, G., White, S. D., Ihrke, P. J., Kass, P. H. and Toebe, N. 2002. Canine atopic dermatitis: a retrospective study of 169 cases examined at the University of California, Davis, 1992-1998. Part II. Response to hyposensitization. Vet. Dermatol. 13: 103-111.