Cytokine-induced killer cells showing multidrug resistance and remaining cytotoxic activity to tumor cell after transfected with mdr1 cDNA

Chinese Medical Journal

Volumn 117, Issue 9, 2004, Pages 1348-1352

  Li, Hui Fang ^a   Yang, Yong Hong ^a   Shi, Yong Jin ^a   Wang, Yi Qun ^a   Zhu, Ping ^a  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

Author keywords

Adoptive; Genes, mdr; Killer cells; Lymphokine activated leukemia immunotherpy

Indexed keywords

COLCHICINE; COMPLEMENTARY DNA; CYTOKINE; DOXORUBICIN; FLUORESCEIN ISOTHIOCYANATE; GAMMA INTERFERON; GLYCOPROTEIN P; INTERLEUKIN 1; INTERLEUKIN 2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD3; MULTIDRUG RESISTANCE PROTEIN 1;

ADOPTIVE IMMUNOTHERAPY; ARTICLE; BLOOD; BREAST CANCER; CANCER CELL CULTURE; CELL COUNT; CELL STRAIN MCF 7; CELL SURFACE; CONTROLLED STUDY; CYTOTOXICITY; ELECTROPORATION; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; KILLER CELL; MULTIDRUG RESISTANCE; PLASMID; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL;

ANTIGENS, CD3; ANTIGENS, CD56; CELL LINE, TUMOR; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; KILLER CELLS; P-GLYCOPROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION;

EID: 4844219894     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Rosenberg SA. Adoptive immunotherapy of cancer using lymphokine activated killer cells and recombinant interlukine-2. Important Adv Oncol 1986;55-91.
2. Rosenberg SA, Spiess P, Lafreniere R. A new approach to the adoptive immunotherapy of cancer with tumor infiltrating lymphocytes. Science 1986;233:1318-1321.
3. Rosenberg SA, Acbersold P, Cornetta K. Gene transfer into humans immunotherapy of patients with advanced melanoma using tumor infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med 1990;323:570-578.
4. Grimm EA, Mazumder A, Zhang HZ, et al. Lymphokine activated killer cell phenomenon: lysis of natural killer resistant fresh solid tumor cells by IL-2 activated autologous human peripheral blood lymphocytes. J Exp Med 1982;155:1823-1841.
5. Rosenberg SA. Lymphokine-activated killer cells. Anew approach to immunotherapy of cancer. J Natl Cancer Inst 1985;75:595-603.
6. Lynch DH, Miller RE. Induction of murine lymphokine-activated killer cells by recombinant IL-7. J Immunol 1990; 145:1983-1990.
7. Yun YS, Hargrove Me, Ting CC. In vivo antitumor activity of anti-CD3 induced activated killer cells. Cancer Res 1989;49: 4770-4774.
8. Schmidt-Wolf IG, Negrin RS, Kiem HP, et al. Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. J Exp Med 1991;74:139-149.
9. Schmidt-Wolf IG, Lefterova P, Johnston V. Propagation of large numbers of T cells with natural killer cell markers. Br J Haematol 1994;87:453-458.
10. + killer cells. Blood 1995;86:3493-3499.
11. + cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency. J Immunol 1994;153:1687-1696.
12. Margolin KA, Negrin RS, Wong KK. Cellular immunotherapy and autologous transplantation for hematologic malignancy. Immunol Rev 1997;157:231-240.
13. Schmidt-Wolf IG, Negrin RS. Phenotypic characterization and identification of effecter cells involved in tumor cell recognition of cytokine induced killer cells. Exp Hematol 1993;21:1673-1679.
14. Scheffold C, Brandt K, Johnston V. Potential of autologous immunologic effector cells for bone marrow purging in patients with chronic myeloid leukemia. Bone Marrow Transplant 1995;15:33-39.
15. Ueda K, Carol C, Michael M. Gottesman. Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Med Sci 1987;84:3004-3008.
16. Mickisch GH, Kossig J, Keilhauer G, et al. Effects of calcium antagonists in multidrug resistant primary renal cell carcinomas. Cancer Res 1990;50:3670-3675.
17. Linn YC, Lau LC, Hui KM. Generation of cytokine-induced cells from leukemia samples with in vitro cytotoxicity against autologous and allogeneic leukemia blasts. Bri J Haematol 2002;116:78-86.
18. + cytotoxic cells from chronic myeloid leukemia patients: in vitro and in vivo efficacy in severe combined immunodeficiency disease mice. Blood 1998;92:3318-3327.
19. + T cells to Fas-mediated apoptosiss. Cancer Immunol Immunother 2000;49:335-345.
20. Schmidt-Wolf IG, Lefterova P, Johnston V, et al. Sensitivity of multidrug-resistant tumor cells lines to immunologic effector cells. Cell Immunol 1996;169:85-90.
21. Shi YJ, Yu JR, Zhu P. Cytokine-induced killers down-regulation the resistant effect of multidrug resistant breast cancer cell line on adriamycin. J Peking Univ Health Sci 2001 (Chin);33:415-418.
22. Ebert O. Lymphocyte apoptosis: induction by gene transfer techniques. Gene Ther 1997;4:296-302.
23. + immunologic effector cells by receptor-mediated transfection with the interleukin-7 gene. Gene Ther 1998;5:31-39.
24. Schmidt-Wolf IG, Finke S, Trojaneck B, et al. Phase 1 clinical study applying autilogous immunological effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma. Br J Cancer 1999;81:1009-1016.