Relationships between MR transverse relaxation parameters R2 * R2 and R2 ′ and hepatic iron content in thalassemic mice at 1.5 T and 3T

NMR in Biomedicine

Volumn 21, Issue 6, 2008, Pages 574-580

  Song, Ruitian ^a   Lin, Wei ^a   Chen, Qiukan ^b   Asakura, Toshio ^b   Wehrli, Felix W ^a   Song, Hee Kwon ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Iron concentration; Liver; MRI; Thalassemia; Transverse relaxation

Indexed keywords

CONCENTRATION (PROCESS);

HEPATIC IRON CONCENTRATION; IRON CONCENTRATION; LIVER; MRI; THALASSEMIA; TRANSVERSE RELAXATION;

IRON;

IRON;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA THALASSEMIA; BLOOD TRANSFUSION; CONTROLLED STUDY; IMAGE ANALYSIS; IMAGE PROCESSING; LIVER LEVEL; MAGNETIC FIELD; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SOUND DETECTION; TISSUE LEVEL; TRANSVERSE RELAXATION RATE;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; IRON; LIVER; MAGNETIC RESONANCE IMAGING; MICE; RADIATION DOSAGE; SENSITIVITY AND SPECIFICITY; THALASSEMIA;

MUS;

EID: 48349126107     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1227     Document Type: Article

References (28)

1. Weir MP, Sharp GA, Peters TJ. Electron microscopic studies of human haemosiderin and ferritin. J. Clin. Pathol. 1985; 38(8): 915-918.
2. Villeneuve JP, Bilodeau M, Lepage R, Cote J, Lefebvre M. Variability in hepatic iron concentration measurement from needle-biopsy specimens. J. Hepatol. 1996; 25(2): 172-177.
3. Brittenham GM, Cohen AR, McLaren CE, Martin MB, Griffith PM, Nienhuis AW, Young NS, Allen CJ, Farrell DE, Harris JW. Hepatic iron stores and plasma ferritin concentration in patients with sickle cell anemia and thalassemia major. Am. J. Hematol. 1993; 42(1): 81-85.
4. St Pierre TG, Clark PR, Chua-anusorn W, Fleming AJ, Jeffrey GP, Olynyk JK, Pootrakul P, Robins E, Lindeman R. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 2005; 105(2): 855-861.
5. 2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 2005; 106(4): 1460-1465.
6. 2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J. 2001; 22(23): 2171-2179.
7. Christoforidis A, Haritandi A, Tsitouridis I, Tsatra I, Tsantali H, Karyda S, Dimitriadis AS, Athanassiou-Metaxa M. Correlative study of iron accumulation in liver, myocardium, and pituitary assessed with MRI in young thalassemic patients. J. Pediatr. Hematol Oncol. 2006; 28(5): 311-315.
8. 2 for the noninvasive assessment of liver iron content by MRI. J. Magn. Reson. Imaging 2003; 17(5): 589-592.
9. St Pierre TG, Clark PR, Chua-Anusorn W. Measurement and mapping of liver iron concentrations using magnetic resonance imaging. Ann. N. Y. Acad. Sci. 2005; 1054: 379-385.
10. Haacke EM, Cheng NYC, House MJ, Liu Q, Neelavalli J, Ogg RJ, Khan A, Ayaz M, Kirsch W, Obenaus A. Imaging iron stores in the brain using magnetic resonance imaging. Magn. Reson. Imaging 2005; 23(1): 1-25.
11. Haque TL, Miki Y, Kanagaki M, Takahashi T, Yamamoto A, Konishi J, Nozaki K, Hashimoto N, Konishi J. MR contrast of ferritin and hemosiderin in the brain: comparison among gradient-echo, conventional spin-echo and fast spin-echo sequences. Eur. J. Radiol. 2003; 48(3): 230-236.
12. Ma J, Wehrli FW. Method for image-based measurement of the reversible and irreversible contribution to the transverse-relaxation rate. J. Magn. Reson. B 1996; 111(1): 61-69.
13. 2 maps: quantification at high intensity field (4.7-T). J. Magn. Reson. Imaging 2001; 13(3): 392-396.
14. 2* imaging of transfusional iron burden at 3 T and comparison with 1.5 T. J. Magn. Reson. Imaging 2007; 25(3): 540-547.
15. Ciavatta DJ, Ryan TM, Farmer SC, Townes TM. Mouse model of human {beta} 0 thalassemia: targeted deletion of the mouse {beta}- maj- and {beta} min-globin genes in embryonic stem cells. Proc. Natl. Acad. Sci. 1995; 92(20): 9259-9263.
16. Stark DD, Bass NM, Moss AA, Bacon BR, McKerrow JH, Cann CE, Brito A, Goldberg HI. Nuclear magnetic resonance imaging of experimentally induced liver disease. Radiology 1983; 148(3): 743-751.
17. Engelhardt R, Langkowski J, Fischer R, Nielsen P, Kooijman H, Heinrich H, Bücheler E. Liver iron quantification: studies in aqueous iron solutions, iron overloaded rats, and patients with hereditary hemochromatosis. Magn. Reson. Imaging 1994; 12(7): 999-1007.
18. 1 in the gerbil model of iron cardiomyopathy. Circulation 2005; 112(4): 535-543.
19. Yablonskiy D, Haacke E. Theory of NMR signal behavior in magnetically inhomogeneous tissues: the static dephasing regime. Magn. Reson. Med. 1994; 32(6): 749-763.
20. Gossuin Y, Roch A, Muller R, Gillis P. Relaxation induced by ferritin and ferritin-like magnetic particles: the role of proton exchange. Magn. Reson. Med. 2000; 43(2): 237-243.
21. Liu P, Henkelman RM, Joshi J, Hardy P, Buany J, Iwanochko M, Clauberg M, Dhar M, Mai D, Waien S, Oliveri N. Quantification of cardiac and tissue iron by nuclear magnetic resonance relaxometry in a novel murine thalassemia-cardiac iron overload model. Can. J. Cardiol. 1996; 12(2): 155-164.
22. Simon CA, Madeleine CB, Amyra T, John MW, Stephen M, Maud IC, Wim de B, Pauline MH. Studies on haemosiderin and ferritin from iron-loaded rat liver. BioMetals 1988; V1(1): 33-42.
23. 2*) predicts cardiac iron in the gerbil model of iron cardiomyopathy. American Society of Hematology Annual Meeting Abstracts 2004; 104(11): 376.
24. Tipnis U, He G-Y, Khan M. Differential induction of polyamine oxidase activity in liver and heart of iron-overloaded rats. J. Toxicol. Environ. Health 1997; 51(3): 235-244.
25. Chua-anusorn W, Webb J. Infrared spectroscopic studies of nanoscale iron oxide deposits isolated from human thalassemic tissues. J. Inorg. Biochem. 2000; 79(1-4): 303-309.
26. Ambu R, Crisponi G, Sciot R, Eyken PV, Parodo G, Ianneli S, Marongiu F, Silvagni R, Nurchi V, Costa V, Faa G, Desmet VJ. Uneven hepatic iron and phosphorus distribution in beta-thalassemia. J. Hepatol. 1995; 23(5): 544-549.
27. 2) images of liver tissue; mapping local tissue iron concentrations with MRI [corrected]. Magn. Reson. Med. 2003; 49(3): 572-575.
28. Stark DD, Moseley ME, Bacon BR, Moss AA, Goldberg HI, Bass NM, James TL. Magnetic resonance imaging and spectroscopy of hepatic iron overload. Radiology 1985; 154(1): 137-142.