Treatment of septic patients with an arginine-based endotoxin adsorber column improves hemodynamics and reduces oxidative stress: Results of a feasibility study

Blood Purification

Volumn 26, Issue 4, 2008, Pages 333-339

  Umgelter, Andreas ^a   Reindl, Wolfgang ^a   Lutz, Jens ^b   Kreymann, Bernhard ^a   Ronco, Claudio ^c   Huber, Wolfgang ^a   Frank, Helga ^b   Schmid, Roland M ^a   Heemann, Uwe ^b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c SAN BORTOLO HOSPITAL   (Italy)

Author keywords

Adsorption; Advanced oxidation protein products; Endotoxemia; Plasmapheresis; Sepsis; Shock, septic

Indexed keywords

ADVANCED OXIDATION PROTEIN PRODUCT; ARGININE; ENDOTOXIN; HYPERTENSIVE FACTOR;

ADULT; AGED; APACHE; APOPTOSIS; ARGININE BASED ENDOTOXIN ADSORBER COLUMN; ARTERIAL PRESSURE; ARTICLE; BRADYCARDIA; CLINICAL ARTICLE; CLINICAL TRIAL; FEASIBILITY STUDY; FEMALE; HEART INDEX; HEART MUSCLE CONTRACTILITY; HEMODYNAMIC PARAMETERS; HEMODYNAMICS; HUMAN; HUMAN CELL; HYPERTENSION; IN VITRO STUDY; INTENSIVE CARE UNIT; MALE; MEDICAL INSTRUMENTATION; MORTALITY; OXIDATIVE STRESS; PLASMAPHERESIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; SEPSIS; SEPTIC SHOCK; TERTIARY HEALTH CARE; TREATMENT OUTCOME; VASODILATATION;

ADULT; AGED; APOPTOSIS; ARGININE; BLOOD PRESSURE; CARDIAC OUTPUT; FEASIBILITY STUDIES; FEMALE; HEMODYNAMICS; HEMOPERFUSION; HOSPITAL MORTALITY; HUMANS; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; OXIDATIVE STRESS; SEPSIS; SHOCK, SEPTIC; VASOCONSTRICTION;

EID: 48349099580     PISSN: 02535068     EISSN: None     Source Type: Journal    
DOI: 10.1159/000132464     Document Type: Article

References (26)

1. Russell JA: Management of sepsis. N Engl J Med 2006;355:1699-1713.
2. Dellinger RP: Cardiovascular management of septic shock. Crit Care Med 2003;31:946-955.
3. Martich GD, Boujoukos AJ, Suffredini AF: Response of man to endotoxin. Immunobiology 1993;187:403-416.
4. Ullrich H, Jakob W, Frohlich D, Rothe G, Prasser C, Drobnik W, Taeger K, Meier-Hellmann A, Reinhart K, Zimmermann M, Schmitz G: A new endotoxin adsorber: first clinical application. Ther Apher 2001;5:326-334.
5. Reinhart K, Meier-Hellmann A, Beale R, Forst H, Boehm D, Willatts S, Rothe KF, Adolph M, Hoffmann JE, Boehme M, Bredle DL; EASy-Study Group: Open randomized phase II trial of an extracorporeal endotoxin adsorber in suspected Gram-negative sepsis. Crit Care Med 2004;32:1662-1668.
6. Vincent JL, Laterre PF, Cohen J, Burchardi H, Bruining H, Lerma FA, Wittebole X, De Backer D, Brett S, Marzo D, Nakamura H, John S: A pilot-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection. Shock 2005;23:400-405.
7. Taniguchi T, Hirai F, Takemoto Y, Tsuda K, Yamamoto K, Inaba H, Sakurai H, Furuyoshi S, Tani N: A novel adsorbent of circulating bacterial toxins and cytokines: the effect of direct hemoperfusion with CTR column for the treatment of experimental endotoxemia. Crit Care Med 2006;34:800-806.
8. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent J-L, Ramsay G: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med 2003;V29:530-538.
9. Goedje O, Peyerl M, Seebauer T, Lamm P, Mair H, Reichart B: Central venous pressure, pulmonary capillary wedge pressure and intrathoracic blood volumes as preload indicators in cardiac surgery patients. Eur J Cardiothorac Surg 1998;13:533-539.
10. Fincke R, Hochman JS, Lowe A, Menon V, Slater J, Webb J, LeJemtel T, Cotte G: Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: a report from the SHOCK trial registry. J Am Coll Cardiol 2004;44:340-348.
11. Bordoni V, Piroddi M, Galli F, de Cal M, Bonello M, Dimitri P, Salvatori G, Ranishta R, Levin N, Tetta C, Ronco C: Oxidant and carbonyl stress-related apoptosis in endstage kidney disease: impact of membrane flux. Blood Purif 2006;24:149-156.
12. Witko-Sarsat V, Friedlander M, Nguyen Khoa T, Capeillère-Blandin C, Nguyen AT, Canteloup S, Dayer JM, Jungers P, Drüeke T, Descamps-Latscha B: Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure. J Immunol 1998;161:2524-2532.
13. Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, Ahn BW, Shaltiel S, Stadtman ER: Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 1990;186:464-478.
14. Duner K: A new kinetic single-stage Limulus amoebocyte lysate method for the detection of endotoxin in water and plasma. J Biochem Biophys Method 1993;26:131-142.
15. Michard F, Alaya S, Zarka V, Bahloul M, Richard Ch, Teboul JL: Global end-diastolic volume as an indicator of cardiac preload in patients with septic shock. Chest 2003;124:1900-1908.
16. Reilly JM, Cunnion RE, Burch-Whitman C, Parker MM, Shelhamer JH, Parrillo JE: A circulating myocardial depressant substance is associated with cardiac dysfunction and peripheral hypoperfusion (lactic acidemia) in patients with septic shock. Chest 1989;95:1072-1080.
17. Pathan N, Sandiford C, Harding SE, Levin M: Characterization of a myocardial depressant factor in meningococcal septicemia. Crit Care Med 2002;30:2191-2198.
18. Tavener SA, Kubes P: Cellular and molecular mechanisms underlying LPS-associated myocyte impairment. Am J Physiol 2006;290:H800-H806.
19. Sforza S, Silipo A, Molinaro A, Marchelli R, Parrilli M, Lanzetta R: Determination of fatty acid positions in native lipid A by positive and negative electrospray ionization mass spectrometry. J Mass Spectrom 2004;39:378-383.
20. Pinsky MR, Vincent JL, Deviere J, Alegre M, Kahn RJ, Dupont E: Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest 1993;103:565-575.
21. Osuchowski MF, Welch K, Siddiqui J, Remick DG: Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol 2006;177:1967-1974.
22. Victor VM, Rocha M, De la Fuente M: Immune cells: free radicals and antixoidants in sepsis. Int Immunopharmacol 2004;4:327-347.
23. Huet O, Obata R, Aubron C, Spraul-Davit A, Charpentier J, Laplace C, Nguyen-Khoa T, Conti M, Vicaut E, Mira JP, Duranteau J: Plasma-induced endothelial oxidative stress is related to the severity of septic shock. Crit Care Med 2007;35:8212-8216.
24. Kietzmann T, Roth U, Jungermann K: Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood 1999;94:4177-4185.
25. Lawson CA, Yan SD, Yan SF, Liao H, Zhou YS, Sobel J, Kisiel W, Stern DM, Pinsky DJ: Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation. J Clin Invest 1997;99:1729-1738.
26. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, Early Goal-Directed Therapy Collaborative Group: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-1377.