Systemic and mucosal immunization with Candida albicans hsp90 elicits hsp90-specific humoral response in vaginal mucosa which is further enhanced during experimental vaginal candidiasis

Medical Mycology

Volumn 46, Issue 5, 2008, Pages 411-420

  Raska, Milan ^a   Belakova, Jana ^a   Horynova, Milada ^a   Krupka, Michal ^a   Novotny, Jiri ^a   Sebestova, Martina ^a   Weigl, Evzen ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Antibody; Candidiasis; DNA vaccine; Hsp90; Recombinant protein vaccine

Indexed keywords

DNA VACCINE; HEAT SHOCK PROTEIN 90; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; RECOMBINANT HEAT SHOCK PROTEIN 90; RECOMBINANT VACCINE;

ACTIVE IMMUNIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; FEMALE; HUMORAL IMMUNITY; IN VITRO STUDY; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE; SPLEEN CELL; VAGINA CANDIDIASIS; VAGINA MUCOSA;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, FUNGAL; ANTIBODY FORMATION; CANDIDA ALBICANS; CANDIDIASIS, VULVOVAGINAL; CELL PROLIFERATION; FEMALE; FUNGAL PROTEINS; FUNGAL VACCINES; HSP90 HEAT-SHOCK PROTEINS; IMMUNIZATION, SECONDARY; INJECTIONS, INTRADERMAL; INJECTIONS, INTRAVENOUS; LYMPHOCYTES; MICE; MICE, INBRED BALB C; SPLEEN; VACCINES, DNA; VACCINES, SYNTHETIC; VAGINA;

CANDIDA; CANDIDA ALBICANS; MUS;

EID: 48249145162     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.1080/13693780701883508     Document Type: Article

References (43)

1. LeBlanc, DM, Barousse, MM and Fidel Jr, PL (2006) Role for dendritic cells in immunoregulation during experimental vaginal candidiasis. 74, pp. 3213-3221.
2. Fidel Jr, PL (2005) Immunity in vaginal candidiasis. 18, pp. 107-111.
3. Fidel Jr, PL (2002) Distinct protective host defenses against oral and vaginal candidiasis. 40, pp. 359-375.
4. Nomanbhoy, F., Steele, C., Yano, J. and Fidel Jr, PL (2002) Vaginal and oral epithelial cell anti-Candida activity. 70, pp. 7081-7088.
5. Lilly, EA, Leigh, JE, Joseph, SH and Fidel Jr, PL (2006) Candida-induced oral epithelial cell responses. 162, pp. 25-32.
6. Bellocchio, S., Montagnoli, C. Bozza, S. et al. (2004) The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo. 172, pp. 3059-3069.
7. Fidel Jr, PL, Lynch, ME and Sobel, JD. (1995) Circulating CD4 and CD8 T cells have little impact on host defense against experimental vaginal candidiasis. 63, pp. 2403-2408.
8. Little, CH, Georgiou, GM Marceglia, A. et al. (2000) Measurement of T-cell-derived antigen binding molecules and immunoglobulin G specific to Candida albicans mannan in sera of patients with recurrent vulvovaginal candidiasis. 68, pp. 3840-3847.
9. Romani, L., Puccetti, P. and Bistoni, F. (1996) Biological role of Th cell subsets in candidiasis. 63, pp. 115-137.
10. Cassone, A., De Bernardis, F. and Torososantucci, A. (2005) An outline of the role of anti-Candida antibodies within the context of passive immunization and protection from candidiasis. 5, pp. 377-382.
11. Han, Y., Morrison, RP and Cutler, JE. (1998) A vaccine and monoclonal antibodies that enhance mouse resistance to Candida albicans vaginal infection. 66, pp. 5771-5776.
12. Magliani, W., Conti, S. Arseni, S. et al. (2005) Antibody-mediated protective immunity in fungal infections. 28, pp. 299-309.
13. Magliani, W., Conti, S. Frazzi, R. et al. (2005) Protective antifungal yeast killer toxin-like antibodies. 5, pp. 443-452.
14. Omaetxebarria, MJ, Moragues, MD Elguezabal, N. et al. (2005) Antifungal and antitumor activities of a monoclonal antibody directed against a stress mannoprotein of Candida albicans. 5, pp. 393-401.
15. Matthews, RC and Burnie, JP. (2005) Human recombinant antibody to HSP90: a natural partner in combination therapy. 5, pp. 403-411.
16. Pachl, J., Svoboda, P. Jacobs, F. et al. (2006) A randomized, blinded, multicenter trial of lipid-associated amphotericin B alone versus in combination with an antibody-based inhibitor of heat shock protein 90 in patients with invasive candidiasis. 42, pp. 1404-1413.
17. Raska, M., Belakova, J. Wudattu, NK et al. (2005) Comparison of protective effect of protein and DNA vaccines hsp90 in murine model of systemic candidiasis. 50, pp. 77-82.
18. Zhang, G., Budker, V. and Wolff, JA. (1999) High Levels of Foreign Gene Expression in hepatocytes after tail vein injections of naked plasmid DNA. 10, pp. 1735-1737.
19. Hamal, P., Koukalova, D. and Hajek, V. (1998) [Personal experience with classification of yeast microorganisms. I. The combined biotyping method of Mencl and Otcenasek and typing using the 'killer' phenomenon]. 47, pp. 87-92.
20. Yang, Q., Wang, L. Lu, DN et al. (2005) Prophylactic vaccination with phage-displayed epitope of C. albicans elicits protective immune responses against systemic candidiasis in C57BL/6 mice. 23, pp. 4088-4096.
21. Balmelli, C., Roden, R. Potts, A. et al. (1998) Nasal immunization of mice with human papillomavirus type 16 virus-like particles elicits neutralizing antibodies in mucosal secretions. 72, pp. 8220-8229.
22. Nardelli-Haefliger, D., Wirthner, D. Schiller, JT et al. (2003) Specific antibody levels at the cervix during the menstrual cycle of women vaccinated with human papillomavirus 16 virus-like particles. 95, pp. 1128-1137.
23. Johansson, EL, Wassen, L., Holmgren, J., Jertborn, M. and Rudin, A. (2001) Nasal and vaginal vaccinations have differential effects on antibody responses in vaginal and cervical secretions in humans. 69, pp. 7481-7486.
24. Raska, M., Belakova, J., Krupka, M. and Weigl, E. (2007) Candidiasis-do we need to fight or to tolerate the Candida fungus?. 52, pp. 297-312.
25. De Bernardis, F., Boccanera, M., Adriani, D., Girolamo, A. and Cassone, A. (2002) Intravaginal and intranasal immunizations are equally effective in inducing vaginal antibodies and conferring protection against vaginal candidiasis. 70, pp. 2725-2729.
26. Romani, L., Mencacci, A. Cenci, E. et al. (1996) Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans. 183, pp. 1345-1355.
27. Wozniak, KL, Wormley Jr, FL and Fidel Jr, PL (2002) Candida-specific antibodies during experimental vaginal candidiasis in mice. 70, pp. 5790-5799.
28. Torosantucci, A., Bromuro, C. Chiani, P. et al. (2005) A novel glyco-conjugate vaccine against fungal pathogens. 202, pp. 597-606.
29. Polonelli, L., Lorenzini, R., De Bernardis, F. and Morace, G. (1986) Potential therapeutic effect of yeast killer toxin. 96, pp. 103-107.
30. De Bernardis, F., Boccanera, M. Adriani, D. et al. (1997) Protective role of antimannan and anti-aspartyl proteinase antibodies in an experimental model of Candida albicans vaginitis in rats. 65 pp. 3399-3405.
31. Matthews, RC and Burnie, JP. (2004) Recombinant antibodies: A natural partner in combinatorial antifungal therapy. 22, pp. 865-871.
32. Soti, C., Racz, A. and Csermely, P. (2002) A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket. 277, pp. 7066-7075.
33. Calderone, RA and Fonzi, WA. (2001) Virulence factors of Candida albicans. 9, pp. 327-335.
34. Matthews, R., Burnie, JP and Lee, W. (1991) The application of epitope mapping in the development of a new serological test for systemic candidosis. 143, pp. 73-79.
35. Matthews, RC, Burnie, JP, Howat, D., Rowland, T. and Walton, F. (1991) Autoantibody to heat-shock protein 90 can mediate protection against systemic candidosis. 74, pp. 20-24.
36. Wang, G., Sun, M. Fang, J. et al. (2006) Protective immune responses against systemic candidiasis mediated by phage-displayed specific epitope of Candida albicans heat shock protein 90 in C57BL/6J mice. 24, pp. 6065-6073.
37. Matthews, R., Hodgetts, S. and Burnie, J. (1995) Preliminary assessment of a human recombinant antibody fragment to hsp90 in murine invasive candidiasis. 171, pp. 1668-1671.
38. Matthews, RC, Rigg, G. Hodgetts, S. et al. (2003) Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90. 47, pp. 2208-2216.
39. Liu, MA, Wahren, B. and Karlsson Hedestam, GB. (2006) DNA vaccines: recent developments and future possibilities. 17, pp. 1051-1061.
40. Ulmer, JB, Wahren, B. and Liu, MA. (2006) Gene-based vaccines: Recent technical and clinical advances. 12, pp. 216-222.
41. Vorup-Jensen, T., Jensen, UB Liu, H. et al. (2001) Tail-vein injection of mannan-binding lectin DNA leads to high expression levels of multimeric protein in liver. 3, pp. 867-874.
42. Bates, MK, Zhang, G. Sebestyen, MG et al. (2006) Genetic immunization for antibody generation in research animals by intravenous delivery of plasmid DNA. 40, pp. 199-208.
43. Silver, PB, Agarwal, RK Su, SB et al. (2007) Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells. 179, pp. 5146-5158.