Principles of stem cell therapy in the horse - The science behind the technology

Pferdeheilkunde

Volumn 24, Issue 4, 2008, Pages 508-512

  Smith, Roger K W ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Horse; Orthopedics; Science; Stem cell therapy; Technology; Tendon; Tendonitis

Indexed keywords

ANIMALIA; EQUIDAE;

EID: 48249126846     PISSN: 01777726     EISSN: None     Source Type: Journal    
DOI: 10.21836/pem20080401     Document Type: Review

References (12)

1. Awad H. A., Butler D. L., Boivin G. P., Smith F. N., Malaviya P., Huibregtse B. and Caplan A. I. (1999) Autologous mesenchymal stem cell-mediated repair of tendon. Tissue Eng. 5, 267-277
2. Guest D. J., Smith M. R. and Allen W. R. (2008) Monitoring the fate of autologous and allogeneic mesenchymal progenitor cells injected into the superficial digital flexor tendon of horses: preliminary study. Equine Vet J. 40, 178-181
3. Hoffmann A., Pelled G., Turgeman G., Eberle P., Zilberman Y., Shinar H., Keinan-Adamsky K., Winkel A., Shahab S., Navon G., Gross G. and Gazit D. (2006) Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells. J. Clin. Invest. 116, 940-952
4. Kajikawa Y., Morihara T., Watanabe N., Sakamoto H., Matsuda K., Kobayashi M., Oshima Y., Yoshida A., Kawata M. and Kubo T. (2007) GFP chimeric models exhibited a biphasic pattern of mesenchymal cell invasion in tendon healing. J Cell Physiol., 210, 684-691
5. Smith J. J., Ross M. W. and Smith R. K. W. (2006) Anabolic effects of acellular bone marrow, platelet rich plasma, and serum on equine ligament fibroblasts in vitro. Vet Comp Orthop Traumatol. 19, 43-47.
6. Smith R. K., Korda M., Blunn G. W. and Goodship A. E. (2003) Isolation and implantation of autologous equine mesenchymal stem cells from bone marrow into the superficial digital flexor tendon as a potential novel treatment. Equine Vet. J. 35, 99-102
7. Wolfman N. M., Hattersley G., Cox K., Celeste A. J., Nelson R., Yamaji N., Dube J. L., DiBlasio-Smith E., Nove J., Song J. J., Wozney J. M. and Rosen V. (1997) Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family. J. Clin. Invest. 100, 321-330
8. Young R. G., Butler D. L., Weber W., Caplan A. I., Gordon S. L. and Fink D. J. (1998) Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair. J. Orthop. Res. 16, 406-413
9. Zantop T., Gilbert T. W., Yoder M. C. and Badylak S. F. (2006) Extracellular matrix scaffolds are repopulated by bone marrow-derived cells in a mouse model of achilles tendon reconstruction. J. Orthop. Res. 24, 1299-1309
10. Richardson L. E., Dudhia J., Clegg P. D. and Smith R. K. W. (2007) Stem cells in veterinary medicine - attempts at regenerating equine tendon after injury. Trends Biotechnol. 9, 409-416
11. Smith R. K. and Webbon P. M. (2005) Harnessing the stem cell for the treatment of tendon injuries: heralding a new dawn? Br. J. Sports Med. 39, 582-584
12. Taylor S. E., Smith R. K. and Clegg P. D. (2007) Mesenchymal stem cell therapy in equine musculoskeletal disease: scientific fact or clinical fiction? Equine Vet. J. 39, 172-180