The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 26, 2008, Pages 9023-9028

  Kemper, Claudia ^a,b   Mitchell, Lynne M ^a   Zhang, Lijuan ^a   Hourcade, Dennis E ^a,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GUY S HOSPITAL   (United Kingdom)

^c Campus Box 8045 ^*  (United States)

Author keywords

Apoptosis; Glycosaminoglycan

Indexed keywords

COMPLEMENT COMPONENT C3B; GLYCOSAMINOGLYCAN; PROPERDIN; PROTEOGLYCAN;

APOPTOSIS; ARTICLE; CELL SURFACE; CELL TYPE; COMPLEMENT ACTIVATION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; NEUTROPHIL; OPSONIZATION; PHAGOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN SECRETION; SERUM; CD4+ T LYMPHOCYTE; CYTOLOGY; DENDRITIC CELL; IMMUNOLOGY; MACROPHAGE; PATHOLOGY;

APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; COMPLEMENT ACTIVATION; COMPLEMENT C3B; DENDRITIC CELLS; GLYCOSAMINOGLYCANS; HUMANS; MACROPHAGES; NEUTROPHILS; PHAGOCYTES; PHAGOCYTOSIS; PROPERDIN; PROTEIN BINDING; PROTEOGLYCANS;

EID: 48249124246     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801015105     Document Type: Article

References (42)

1. Kerr JF, Wyllie AH, Currie AR (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257.
2. Krammer PH (2000) CD95's deadly mission in the immune system. Nature 407:789-795.
3. Savill J, Fadok V (2000) Corpse clearance defines the meaning of cell death. Nature 407:784-788.
4. Huynh ML, Fadok VA, Henson PM (2002) Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest 109:41-50.
5. Savill J, Dransfield I, Gregory C, Haslett C (2002) A blast from the past: Clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2:965-975.
6. Fadok VA, Bratton DL, Henson PM (2001) Phagocyte receptors for apoptotic cells: Recognition, uptake, and consequences. J Clin Invest 108:957-962.
7. Fadok VA, et al. (1992) Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148:2207-2216.
8. Fadok VA, et al. (2000) A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature 405:85-90.
9. Ren Y, Silverstein RL, Allen J, Savill J (1995) CD36 gene transfer confers capacity for phagocytosis of cells undergoing apoptosis. J Exp Med 181:1857-1862.
10. Verhoven B, Schlegel RA, Williamson P (1995) Mechanisms of phosphatidylserine exposure, a phagocyte recognition signal, on apoptotic T lymphocytes. J Exp Med 182:1597-1601.
11. Schagat TL, Wofford JA, Wright JR (2001) Surfactant protein A enhances alveolar macrophage phagocytosis of apoptotic neutrophils. J Immunol 166:2727-2733.
12. Mevorach D, Mascarenhas JO, Gershov D, Elkon KB (1998) Complement-dependent clearance of apoptotic cells by human macrophages. J Exp Med 188:2313-2320.
13. Volanakis JE (1998) in The human Complement System in Health and Disease, eds Volanakis JE, Frank MM (Marcel Dekker, New York), pp 9-32.
14. Lambris JD, Ricklin D, Geisbrecht BV (2008) Complement evasion by human pathogens. Nat Rev Microbiol 6:132-142.
15. Ogden CA, et al. (2001) C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 194:781-795.
16. Taylor PR, et al. (2000) A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo. J Exp Med 7:359-366.
17. Roos A, et al. (2004) Mini-review: A pivotal role for innate immunity in the clearance of apoptotic cells. Eur J Immunol 34:921-929.
18. Korb LC, Ahearn JM (1997) C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes. J Immunol 158:4525-4528.
19. Botto M, et al. (1998) Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet 19:56-59.
20. Fearon DT, Austen KF (1975) Properdin: Binding to C3b and stabilization of the C3b-dependent C3 convertase. J Exp Med 142:856-863.
21. Hourcade D (2006) The role of properdin in the assembly of the alternative pathway C3 convertases of complement. J Biol Chem 281:2128-2132.
22. Spitzer D, Mitchell LM, Atkinson JP, Hourcade DE (2007) Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly. J Immunol 179:2600-2608.
23. Nolan KF, Reid KB (1993) Properdin. Methods Enzymol 223:35-46.
24. Yu H, Munoz EM, Edens RE, Linhardt RJ (2005) Kinetic studies on the interactions of heparin and complement proteins using surface plasmon resonance. Biochim Biophys Acta 1726:168-176.
25. Esko JD, Selleck SB (2002) Order out of chaos: Assembly of ligand binding sites in heparan sulfate. Annu Rev Biochem 71:435-471.
26. Zhang L, Lawrence R, Frazier BA, Esko JD (2006) CHO glycosylation mutants: Proteoglycans. Methods Enzymol 416:205-221.
27. Esko JD, Stewart TE, Taylor WH (1985) Animal cell mutants defective in glycosaminoglycan biosynthesis. Proc Natl Acad Sci USA 82:3197-3201.
28. Baeuerle PA, Huttner WB (1986) Chlorate - a potent inhibitor of protein sulfation in intact cells. Biochem Biophys Res Commun 141:870-877.
29. Wirthmueller U, et al. (1997) Properdin, a positive regulator of complement activation, is released from secondary granules of stimulated peripheral blood neutrophils. J Immunol 158:4444-4451.
30. Schwaeble WJ, Reid KB (1999) Does properdin crosslink the cellular and the humoral immune response? Immunol Today 20:17-21.
31. Wright SD, Silverstein SC (1983) Receptors for C3b and C3bi promote phagocytosis but not the release of toxic oxygen from human phagocytes. J Exp Med 158:2016-2023.
32. Sjoholm AG, et al. (1988) Dysfunctional properdin in a Dutch family with meningococcal disease. N Engl J Med 319:33-37.
33. Holme ER, et al. (1989) Familial properdin deficiency associated with chronic discoid lupus erythematosus. Clin Exp Immunol 76:76-81.
34. Sjoblom T, et al. (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314:268-274.
35. Smith CA, Pangburn MK, Vogel CW, Muller-Eberhard HJ (1984) Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement. J Biol Chem 259:4582-4588.
36. Nolan KF, et al. (1991) Molecular cloning of the cDNA coding for properdin, a positive regulator of the alternative pathway of human complement. Eur J Immunol 21:771-776.
37. Tossavainen H, et al. (2006) The layered fold of the TSR domain of P. falciparum TRAP contains a heparin binding site. Protein Sci 15:1760-1768.
38. Tan K, et al. (2002) Crystal structure of the TSP-1 type 1 repeats: A novel layered fold and its biological implication. J Cell Biol 159:373-382.
39. Medhzitov R, Janeway CJ (2002) Decoding the patterns of self and non-self by the innate immune system. Science 296:298-300.
40. Kabelitz D, Medzhitov R (2007) Innate immunity - cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol 19:1-3.
41. Barchet W, et al. (2006) Complement-induced regulatory T cells suppress T cell responses but allow for dendritic cell maturation. Blood 107:1497-1504.
42. Xu W, et al. (2008) Properdin binds to late apoptotic and necrotic cells independently of C3b and regulates alternative pathway complement activation. J Immunol 180:7613-7621.