Diacetyl and bronchiolitis obliterans [2]

American Journal of Respiratory and Critical Care Medicine

Volumn 178, Issue 3, 2008, Pages 13-14

  Van Rooy, Frits G B G J ^a   Rooyackers, Jos M ^b   Prokop, Mathias ^b   Houba, Remko ^c   Smit, Lidwien A M ^a   Heederik, Dick J J ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Netherlands Expertise Center for Occupational Respiratory Disorders NECORD   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 BUTANEDIONE; FLAVORING AGENT;

AIRWAY OBSTRUCTION; BRONCHIOLITIS OBLITERANS; COMPUTER ASSISTED TOMOGRAPHY; HUMAN; LETTER; LUNG BIOPSY; MICROWAVE COOKING; NONHUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HAZARD; PRIORITY JOURNAL; PROPHYLAXIS; SYMPTOM; WORKER;

EID: 48249111329     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: None     Document Type: Letter

References (7)

1. van Rooy FGBGJ, Rooyackers JM, Prokop M, Houba R, Smit LAM, Heederik DJJ. Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings. Am J Respir Crit Care Med 2007;176:498-504.
2. Kreiss K, Gomaa A, Kullman G, Fedan K, Simoes EJ, Enright PL. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N Engl J Med 2002;347:330-338.
3. Akpinar-Elci M, Travis WD, Lynch DA, Kreiss K. Bronchiolitis obliterans syndrome in popcorn production plant workers. Eur Respir J 2004;24:298-302.
4. Hubbs AF, Battelli LA, Goldsmith WT, Porter DW, Frazer D, Friend S, Swegler-Berry D, Mercer RR, Reynolds JS, Grote A, et al. Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol Appl Pharmacol 2002;185:128-135.
5. Hubbs AF, Battelli LA, Mercer RR, Kashon M, Friend S, Schwegler-Berry D, Goldsmith WT. Inhalation toxicity of the flavoring agent, diacetyl (2,3-butanedione), in the upper respiratory tract of rats [abstract]. Toxicol Sci 2004;78:438-439.
6. Hubbs AF, Kreiss K, Kanwal R, Kullman G, Frazer D, Goldsmith WT, Kashon ML, Mercer RR, Schwegler-Berry D, Battelli LA,et al. Pulsed and continuous patterns of diacetyl (2,3-butanedione) inhalation cause rhinitis, laryngitis, tracheitis, and bronchitis in rats [abstract]. Vet Pathol 2007;44:5.
7. Morgan DL, Flake G, Kirby PJ, Burka LT, Kleeberger SR, Garantziotis S, Germolec DR, Palmer SM. Respiratory tract toxicity of diacetyl in c57bl/6 mice [abstract]. Vet Pathol 2007;44:732-785.