Optimisation of an enteric coated, layered multi-particulate formulation for ileal delivery of viable recombinant Lactococcus lactis

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 69, Issue 3, 2008, Pages 969-976

  Poelvoorde, Nele ^a   Huyghebaert, Nathalie ^a   Vervaet, Chris ^a   Remon, Jean Paul ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Eudragit; Ileum targeting; Lactose; Layering; Pellets; Recombinant Lactococcus lactis; Skim milk; Viability

Indexed keywords

CALCIUM CASEINATE; CELLETS; EUDRAGIT; GLUCOSE; GLYCEROL STEARATE; HYDROCHLORIC ACID; ISOMALT; LACTOSE; MALTODEXTRIN; MANNITOL; METHYLCELLULOSE; MICROCRYSTALLINE CELLULOSE; OPADRY AMB; OPADRY II; POLYSORBATE 80; POLYVINYL ALCOHOL; SORBITOL; STARCH; SUCROSE; TREHALOSE; UNCLASSIFIED DRUG; UNI PURE;

ARTICLE; BACTERIAL CELL; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; ENTERIC COATED TABLET; ILEUM; LACTOCOCCUS LACTIS; MILK; NONHUMAN; SHEAR STRESS; SUSPENSION;

ANIMALS; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; CROHN DISEASE; CULTURE MEDIA; DRUG DELIVERY SYSTEMS; EXCIPIENTS; HUMANS; ILEUM; INTERLEUKIN-10; LACTOCOCCUS LACTIS; MILK; POLYMETHACRYLIC ACIDS; POLYVINYL ALCOHOL; STARCH; STOMACH; TABLETS, ENTERIC-COATED; THYMIDINE;

EID: 48149110497     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.02.018     Document Type: Article

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