Randomised trial of oral versus sequential intravenous/oral cephalosporins in children with pyelonephritis

European Journal of Pediatrics

Volumn 167, Issue 9, 2008, Pages 1037-1047

  Neuhaus, Thomas J ^a   Berger, Christoph ^a   Buechner, Katja ^a   Parvex, Paloma ^b   Bischoff, Gian ^c   Goetschel, Philippe ^d   Husarik, Daniela ^e   Willi, Ulrich ^a   Molinari, Luciano ^a   Rudin, Christoph ^f   Gervaix, Alain ^b   Hunziker, Urs ^c   Stocker, Sergio ^a   Girardin, Eric ^b   Nadal, David ^a  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b Hopital des Enfants Hopitaux universitaires de Geneve   (Switzerland)

^c CANTONAL HOSPITAL WINTERTHUR   (Switzerland)

^d TRIEMLI HOSPITAL   (Switzerland)

^e UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^f UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

Ceftibuten; Child; Out patient; Pyelonephritis; Scintigraphy

Indexed keywords

CEFTIBUTEN; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; SUCCIMER;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRACTICE GUIDELINE; PRESCHOOL CHILD; PRIORITY JOURNAL; PYELONEPHRITIS; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; TREATMENT OUTCOME; VESICOURETERAL REFLUX;

ADMINISTRATION, ORAL; ADOLESCENT; ANTI-BACTERIAL AGENTS; CEFTRIAXONE; CEPHALOSPORINS; CHILD; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; INFANT; INJECTIONS, INTRAVENOUS; MALE; PYELONEPHRITIS; TECHNETIUM TC 99M DIMERCAPTOSUCCINIC ACID;

EID: 48149099926     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00431-007-0638-1     Document Type: Article

References (35)

1. American Academy of Pediatrics, Committee on Quality Improvement, Subcommittee on Urinary Tract Infection 1999 Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children Pediatrics 103 843 852
2. R Bachur GL Caputo 1995 Bacteremia and meningitis among infants with urinary tract infections Pediatr Emerg Care 11 280 284
3. A Banfi G Gabriele JM Hill-Juarez A Kaufman E Moens group amotcutiis 1993 Multinational comparative trial of ceftibuten and trimethoprim-sulfamethoxazole in the treatment of children with complicated or recurrent urinary tract infections Pediatr Infect Dis J 12 S84 S91
4. WH Barr M Affrime CC Lin V Batra 1995 Pharmacokinetics of ceftibuten in children Pediatr Infect Dis J 14 S93 S101
5. D Benador TJ Neuhaus JP Papazyan UV Willi I Engel-Bicik D Nadal D Slosman B Mermillod E Girardin 2001 Randomised controlled trial of three day versus 10 day intravenous antibiotics in acute pyelonephritis: effect on renal scarring Arch Dis Child 84 241 246
6. Bloomfield P, Hodson EM, Craig JC (2003) Antibiotics for acute pyelonephritis in children. Cochrane Database Syst Rev:CD003772
7. EF Crain JC Gershel 1990 Urinary tract infections in febrile infants younger than 8 weeks of age Pediatrics 86 363 367
8. B de La Vaissière B Castello B Quinet R Cohen E Grimpel 2006 Management of acute pyelonephritis in patients older than 3 months: survey conducted in 39 paediatric emergency departments of the Ile de France Region in 2004 Arch Pediatr 13 245 250
9. MR Ditchfield K Grimwood DJ Cook HR Powell R Sloane S Gulati JF De Campo 2004 Persistent renal cortical scintigram defects in children 2 years after urinary tract infection Pediatr Radiol 34 465 471
10. NP Goldraich IH Goldraich 1995 Update on dimercaptosuccinic acid renal scanning in children with urinary tract infection Pediatr Nephrol 9 221 226
11. NP Goldraich OL Ramos IH Goldraich 1989 Urography versus DMSA scan in children with vesicoureteric reflux Pediatr Nephrol 3 1 5
12. E González JP Papazyan E Girardin 2005 Impact of vesicoureteral reflux on the size of renal lesions after an episode of acute pyelonephritis J Urol 173 571 574 Discussion 574-575
13. Group SPN (2001) Treatment of urinary tract infections in children. Paediatrica 12:16-21
14. A Hoberman ER Wald RW Hickey M Baskin M Charron M Majd DH Kearney EA Reynolds J Ruley JE Janosky 1999 Oral versus initial intravenous therapy for urinary tract infections in young febrile children Pediatrics 104 79 86
15. B Jakobsson U Berg L Svensson 1994 Renal scarring after acute pyelonephritis Arch Dis Child 70 111 115
16. B Jakobsson L Svensson 1997 Transient pyelonephritic changes on 99mTechnetium-dimercaptosuccinic acid scan for at least five months after infection Acta Paediatr 86 803 807
17. RN Jones 1995 Ceftibuten: a review of antimicrobial activity, spectrum and other microbiologic features Pediatr Infect Dis J 14 S77 S83
18. EC Kavanagh S Ryan A Awan S McCourbrey R O'Connor V Donoghue 2005 Can MRI replace DMSA in the detection of renal parenchymal defects in children with urinary tract infections? Pediatr Radiol 35 275 281
19. ME Klepser MN Marangos KB Patel DP Nicolau R Quintiliani CH Nightingale 1995 Clinical pharmacokinetics of newer cephalosporins Clin Pharmacokinet 28 361 384
20. T Lahdes-Vasama K Niskanen K Rönnholm 2006 Outcome of kidneys in patients treated for vesicoureteral reflux (VUR) during childhood Nephrol Dial Transplant 21 2491 2497
21. G Montini A Toffolo P Zucchetta R Dall'Amico D Gobber A Calderan F Maschio L Pavanello PP Molinari D Scorrano S Zanchetta W Cassar P Brisotto A Corsini S Sartori L Da Dalt L Murer G Zacchello 2007 Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial BMJ 335 386
22. I Moorthy M Easty K McHugh D Ridout L Biassoni I Gordon 2005 The presence of vesicoureteric reflux does not identify a population at risk for renal scarring following a first urinary tract infection Arch Dis Child 90 733 736
23. HC Neu 1995 Ceftibuten: minimal inhibitory concentrations, postantibiotic effect and beta-lactamase stability-a rationale for dosing programs Pediatr Infect Dis J 14 S88 S92
24. P Orellana P Baquedano V Rangarajan JH Zhao ND Eng J Fettich T Chaiwatanarat K Sonmezoglu D Kumar YH Park AM Samuel R Sixt V Bhatnagar AK Padhy 2004 Relationship between acute pyelonephritis, renal scarring, and vesicoureteral reflux. Results of a coordinated research project Pediatr Nephrol 19 1122 1126
25. RD Pitetti S Choi 2002 Utility of blood cultures in febrile children with UTI Am J Emerg Med 20 271 274
26. C Polito PF Rambaldi G Signoriello L Mansi A La Manna 2006 Permanent renal parenchymal defects after febrile UTI are closely associated with vesicoureteric reflux Pediatr Nephrol 21 521 526
27. MF Prère P Licznar S Decramer O Fayet 2004 E. coli from urinary tract infections and acute pyelonephritis of children: 1% of strains are resistant to a subset of third generation cephalosporins Pathol Biol (Paris) 52 497 500
28. BE Reidenberg 1995 Worldwide safety experience with ceftibuten pediatric suspension Pediatr Infect Dis J 14 S130 S133
29. HG Rushton M Majd 1992 Dimercaptosuccinic acid renal scintigraphy for the evaluation of pyelonephritis and scarring: a review of experimental and clinical studies J Urol 148 1726 1732
30. E Stokland M Hellström B Jacobsson U Jodal R Sixt 1996 Renal damage one year after first urinary tract infection: role of dimercaptosuccinic acid scintigraphy J Pediatr 129 815 820
31. A Vilaichone D Watana T Chaiwatanarat 2001 Oral ceftibuten switch therapy for acute pyelonephritis in children J Med Assoc Thai 84 Suppl 1 S61 S67
32. M Wennerström S Hansson T Hedner A Himmelmann U Jodal 2000 Ambulatory blood pressure 16-26 years after the first urinary tract infection in childhood J Hypertens 18 485 491
33. M Wennerström S Hansson U Jodal R Sixt E Stokland 2000 Renal function 16 to 26 years after the first urinary tract infection in childhood Arch Pediatr Adolesc Med 154 339 345
34. LR Wiseman JA Balfour 1994 Ceftibuten. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy Drugs 47 784 808
35. M Zaki M Badawi G Al Mutari D Ramadan M Adul Rahman 2005 Acute pyelonephritis and renal scarring in Kuwaiti children: a follow-up study using 99mTc DMSA renal scintigraphy Pediatr Nephrol 20 1116 1119