Catecholaminergic polymorphic ventricular tachycardia-related mutations R33Q and L167H alter calcium sensitivity of human cardiac calsequestrin

Biochemical Journal

Volumn 413, Issue 2, 2008, Pages 291-303

  Valle, Giorgia ^a   Galla, Daniela ^a   Nori, Alessandra ^a   Priori, Silvia G ^b   Gyorke, Sandor ^c   De Filippis, Vincenzo ^a   Volpe, Pompeo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Calcium binding; Calsequestrin; Circular dichroism; Fluorescence; Protein stability; Proteolysis

Indexed keywords

CALCIUM;

CALCIUM SENSITIVITY; MISSENSE MUTATIONS; SARCOPLASMIC RETICULUM (SR); VENTRICULAR TACHYCARDIA (VT);

ANIMAL CELL CULTURE;

AMINO ACID; ARGININE; CALCIUM; CALSEQUESTRIN; GLUTAMINE; MUTANT PROTEIN; RECOMBINANT PROTEIN; UREA; CAISEQUESTRIN 2, RAT; CALCIUM BINDING PROTEIN; CATECHOLAMINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CIRCULAR DICHROISM; CONTROLLED STUDY; GEL PERMEATION CHROMATOGRAPHY; GENE EXPRESSION; HUMAN; MISSENSE MUTATION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN PURIFICATION; PROTEIN STABILITY; PROTEIN STRUCTURE; SPECTROFLUOROMETRY; TURBIDIMETRY; ANIMAL; CHEMISTRY; GENETIC POLYMORPHISM; GENETICS; HEART MUSCLE; HEART VENTRICLE TACHYCARDIA; METABOLISM; METHODOLOGY; MUTATION; RAT; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; CALCIUM; CALCIUM-BINDING PROTEINS; CALSEQUESTRIN; CATECHOLAMINES; HUMANS; MUTATION; MYOCARDIUM; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION; RATS; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; TACHYCARDIA, VENTRICULAR;

EID: 48149096419     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20080163     Document Type: Article

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