Molecular characterisation of breast cancer patients at high and low recurrence risk

Virchows Archiv

Volumn 452, Issue 3, 2008, Pages 241-250

  Bonin, Serena ^a   Brunetti, Davide ^b   Benedetti, Elena ^c   Dotti, Isabella ^a   Gorji, Nader ^d   Stanta, Giorgio ^a,e  

^a UNIVERSITY OF TRIESTE   (Italy)

^b Registro Tumori Friuli Venezia Giulia   (Italy)

^c INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Breast cancer; CDK2; CK8; Formalin fixed paraffin embedded tissues; HER2; Quantitative RT PCR; RB

Indexed keywords

CYCLIN DEPENDENT KINASE 2; CYTOKERATIN 8; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; NUCLEOSIDE DIPHOSPHATE KINASE A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P130; RAF PROTEIN; AKT3 PROTEIN, HUMAN; CDK2 PROTEIN, HUMAN; RETINOBLASTOMA PROTEIN;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER MORTALITY; CANCER RECURRENCE; CANCER RELAPSE; CANCER SURVIVAL; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; METASTASIS POTENTIAL; MOLECULAR GENETICS; PRIORITY JOURNAL; QUANTITATIVE GENETICS; RECURRENCE RISK; RETINOBLASTOMA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BREAST TUMOR; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; STATISTICS; SURVIVAL; TUMOR RECURRENCE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AGED; BREAST NEOPLASMS; COHORT STUDIES; CYCLIN-DEPENDENT KINASE 2; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KERATIN-8; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PROPORTIONAL HAZARDS MODELS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-RAF; RECEPTOR, ERBB-2; RETINOBLASTOMA PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK FACTORS; SURVIVAL ANALYSIS;

EID: 48149095681     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-007-0570-9     Document Type: Article

References (30)

1. Agenzia Regionale della Sanità (2002) Registro tumori regionale-dati di incidenza 1995-1998. Agenzia Regionale della Sanità, Italy
2. S Bonin D Brunetti E Benedetti N Gorji G Stanta 2006 Expression of cyclin-dependent kinases and CDC25a phosphatase is related with recurrences and survival in women with peri- and post-menopausal breast cancer Virchows Arch 448 5 539 544
3. S Bonin L Pascolo LS Croce G Stanta C Tiribelli 2002 Gene expression of ABC proteins in hepatocellular carcinoma, perineoplastic tissue, and liver diseases Mol Med 8 6 318 325
4. M Derenzini L Montanaro M Vici S Barbieri C Ceccarelli D Santini M Taffurelli GN Martinelli D Trere 2007 Relationship between the RB1 mRNA level and the expression of phosphorylated RB protein in human breast cancers: their relevance in cell proliferation activity and patient clinical outcome Histol Histopathol 22 5 505 513
5. GP Dimri 2005 What has senescence got to do with cancer? Cancer Cell 7 6 505 512
6. CW Elston IO Ellis 1991 Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up Histopathology 19 5 403 410
7. C Fan DS Oh L Wessels B Weigelt DS Nuyten AB Nobel van LJ t Veer CM Perou 2006 Concordance among gene-expression-based predictors for breast cancer N Engl J Med 355 6 560 569
8. JA Fresno Vara E Casado J de Castro P Cejas C Belda-Iniesta M Gonzalez-Baron 2004 PI3K/Akt signalling pathway and cancer Cancer Treat Rev 30 2 193 204
9. IB Fuchs W Lichtenegger H Buehler W Henrich H Stein A Kleine-Tebbe G Schaller 2002 The prognostic significance of epithelial-mesenchymal transition in breast cancer Anticancer Res 22 6A 3415 3419
10. Greene FL, Page DL, Fleming ID, Fritz A, Balch MC, Haller DG, Morrow M (2002) AJCC cancer staging manual. Springer, New York
11. WC Hines AM Fajardo NE Joste M Bisoffi JK Griffith 2005 Quantitative and spatial measurements of telomerase reverse transcriptase expression within normal and malignant human breast tissues Mol Cancer Res 3 9 503 509
12. SD Kendall CM Linardic SJ Adam CM Counter 2005 A network of genetic events sufficient to convert normal human cells to a tumorigenic state Cancer Res 65 21 9824 9828
13. IG Maroulakou W Oemler SP Naber PN Tsichlis 2007 Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice Cancer Res 67 1 167 177
14. JA McCubrey LS Steelman SL Abrams JT Lee F Chang FE Bertrand PM Navolanic DM Terrian RA Franklin AB D'Assoro JL Salisbury MC Mazzarino F Stivala M Libra 2006 Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance Adv Enzyme Regul 46 249 279
15. RR Mewani S Tian B Li MT Danner TD Carr S Lee A Rahman UN Kasid M Jung A Dritschilo PC Gokhale 2006 Gene expression profile by inhibiting Raf-1 protein kinase in breast cancer cells Int J Mol Med 17 3 457 463
16. E Nardon I Buda G Stanta E Buratti M Fonda L Cattin 2003 Insulin-like growth factor system gene expression in women with type 2 diabetes and breast cancer J Clin Pathol 56 8 599 604
17. J Paredes N Lopes F Milanezi FC Schmitt 2007 P-cadherin and cytokeratin 5: useful adjunct markers to distinguish basal-like ductal carcinomas in situ Virchows Archiv 450 73 80
18. Parkin DM, Whelan SL, Ferlay J, Raymond L, Young J (1997) Cancer incidence in five continents, vol. VII. International Agency for Research on Cancer, Lyon, pp 562-565
19. SK Penland TO Keku C Torrice X He J Krishnamurthy KA Hoadley JT Woosley NE Thomas CM Perou RS Sandler NE Sharpless 2007 RNA expression analysis of formalin-fixed paraffin-embedded tumors Lab Invest 87 4 383 391
20. L Perreard C Fan JF Quackenbush M Mullins NP Gauthier E Nelson M Mone H Hansen SS Buys K Rasmussen AR Orrico D Dreher R Walters J Parker Z Hu X He JP Palazzo OI Olopade A Szabo CM Perou PS Bernard 2006 Classification and risk stratification of invasive breast carcinomas using a real-time quantitative RT-PCR assay Breast Cancer Res 8 2 R23
21. L Pusztai C Mazouni K Anderson Y Wu WF Symmans 2006 Molecular classification of breast cancer: limitations and potential Oncologist 11 8 868 877
22. Salhab M, Jiang WG, Newbold RF, Mokbel K (2007) The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome. Breast Cancer Res Treat (in press)
23. CJ Sherr F McCormick 2002 The RB and p53 pathways in cancer Cancer Cell 2 2 103 112
24. G Stanta S Bonin 1998 RNA quantitative analysis from fixed and paraffin-embedded tissues: membrane hybridization and capillary electrophoresis Biotechniques 24 2 271 276
25. G Stanta S Bonin L Losi V Eusebi 1998 Molecular characterization of intraductal breast carcinomas Virchows Arch 432 2 107 111
26. G Stanta S Bonin B Niccolini A Raccanelli F Baralle 1999 Catalytic subunit of telomerase expression is related to RNA component expression FEBS Lett 460 2 285 288
27. G Stanta C Schneider 1991 RNA extracted from paraffin-embedded human tissues is amenable to analysis by PCR amplification Biotechniques 11 3 304, 306, 308
28. L Su PR Morgan EB Lane 1996 Expression of cytokeratin messenger RNA versus protein in the normal mammary gland and in breast cancer Human Pathol 27 8 800 806
29. E Tokunaga Y Kimura K Mashino E Oki A Kataoka S Ohno M Morita Y Kakeji H Baba Y Maehara 2006 Activation of PI3K/Akt signaling and hormone resistance in breast cancer Breast Cancer 13 2 137 144
30. BC Yankaskas 2005 Epidemiology of breast cancer in young women Breast Dis 23 3 8