VLDL exits from the endoplasmic reticulum in a specialized vesicle, the VLDL transport vesicle, in rat primary hepatocytes

Biochemical Journal

Volumn 413, Issue 2, 2008, Pages 333-342

  Siddiqi, Shadab A ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Apolipoprotein B (apoB); Endoplasmic reticulum (ER); Triacylglycerol (TAG); Very low density lipoprotein (VLDL); VLDL transport vesicle (VTV)

Indexed keywords

ATHEROSCLEROSIS (AS); ELEVATED CONCENTRATIONS; ENDOPLASMIC RETICULUM (EI); HEPATOCYTES; IN-VITRO; LOW DENSITY LIPOPROTEIN (LDL); PRIMARY HEPATOCYTES; PROTEIN TRANSPORT;

ELECTRIC RESISTANCE;

ADENOSINE TRIPHOSPHATE; ALBUMIN; APOLIPOPROTEIN; CALNEXIN; GUANOSINE TRIPHOSPHATASE; N ACETYL BETA GLUCOSAMINIDASE; OLEIC ACID; SUCROSE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN; GLYCOSIDASE; PROTEINASE; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CELL FRACTIONATION; CELL ISOLATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; IMMUNOBLOTTING; IN VITRO STUDY; LIVER CELL; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PURIFICATION; PROTEIN TRANSPORT; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CYTOLOGY; CYTOSOL; LIVER; METABOLISM; RAT;

PERU TOMATO MOSAIC VIRUS; RATTUS;

ANIMALS; CYTOSOL; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; GLYCOSIDE HYDROLASES; GOLGI APPARATUS; HEPATOCYTES; LIPOPROTEINS, VLDL; LIVER; MODELS, BIOLOGICAL; PROTEIN TRANSPORT; RATS; RECOMBINANT PROTEINS; SUCROSE; TRIGLYCERIDES;

EID: 48149087127     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071469     Document Type: Article

References (48)

1. Olofsson, S. O., Asp, L. and Boren, J. (1999) The assembly and secretion of apolipoprotein B-containing lipoproteins. Curr. Opin. Lipidol. 10, 341-346
2. Alexander, C. A., Hamilton, R. L. and Havel, R. J. (1976) Subcellular localization of B apoprotein of plasma lipoproteins in rat liver. J. Cell Biol. 69, 241-263
3. Shelness, G. S., Ingram, M. F., Huang, X. F. and DeLozier, J. A. (1999) Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assembly. J. Nutr. 129, 456S-462S
4. Jamil, H., Gordon, D. A., Eustice, D. C., Brooks, C. M., Dickson, Jr, J. K., Chen, Y., Ricci, B., Chu, C. H., Harrity, T. W., Ciosek, Jr, C. P. et al. (1996) An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells. Proc. Natl. Acad. Sci. U.S.A. 93, 11991-11995
5. Bakillah, A., Nayak, N., Saxena, U., Medford, R. M. and Hussain, M. M. (2000) Decreased secretion of ApoB follows inhibition of ApoB-MTP binding by a novel antagonist. Biochemistry 39, 4892-4899
6. Claude, A. (1970) Growth and differentiation of cytoplasmic membranes in the course of lipoprotein granule synthesis in the hepatic cell. I. Elaboration of elements of the Golgi complex. J. Cell Biol. 47, 745-766
7. Morre, D. J. and Ovtracht, L. (1981) Structure of rat liver Golgi apparatus: relationship to lipoprotein secretion. J. Ultrastruct. Res. 74, 284-295
8. Borchardt, R. A. and Davis, R. A. (1987) Intrahepatic assembly of very low density lipoproteins. Rate of transport out of the endoplasmic reticulum determines rate of secretion. J. Biol. Chem. 262, 16394-16402
9. Rusinol, A., Verkade, H. and Vance, J. E. (1993) Assembly of rat hepatic very low density lipoproteins in the endoplasmic reticulum. J. Biol. Chem. 268, 3555-3562
10. Kulinski, A., Rustaeus, S. and Vance, J. E. (2002) Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. J. Biol. Chem. 277, 31516-31525
11. Yamaguchi, J., Gamble, M. V., Conlon, D., Liang, J. S. and Ginsberg, H. N. (2003) The conversion of apoB100 low density lipoprotein/high density lipoprotein particles to apoB100 very low density lipoproteins in response to oleic acid occurs in the endoplasmic reticulum and not in the Golgi in McA RH7777 cells. J. Biol. Chem. 278, 42643-42651
12. Bamberger, M. J. and Lane, M. D. (1990) Possible role of the Golgi apparatus in the assembly of very low density lipoprotein. Proc. Natl. Acad. Sci. U.S.A. 87, 2390-2394
13. Higgins, J. A. (1988) Evidence that during very low density lipoprotein assembly in rat hepatocytes most of the triacylglycerol and phospholipid are packaged with apolipoprotein B in the Golgi complex. FEBS Lett. 232, 405-408
14. Tran, K., Thorne-Tjomsland, G., DeLong, C. J., Cui, Z., Shan, J., Burton, L., Jamieson, J. C. and Yao, Z. (2002) Intracellular assembly of very low density lipoproteins containing apolipoprotein B100 in rat hepatoma McA-RH7777 cells. J. Biol. Chem. 277, 31187-31200
15. Gusarova, V., Seo, J., Sullivan, M. L., Watkins, S. C., Brodsky, J. L. and Fisher, E. A. (2007) Golgi-associated maturation of very low density lipoproteins involves conformational changes in apolipoprotein B, but is not dependent on apolipoprotein E. J. Biol. Chem. 282, 19453-19462
16. Barlowe, C. (1998) COPII and selective export from the endoplasmic reticulum. Biochim. Biophys. Acta 1404, 67-76
17. Barlowe, C., Orci, L., Yeung, T., Hosobuchi, M., Hamamoto, S., Salama, N., Rexach, M. F., Ravazzola, M., Amherdt, M. and Schekman, R. (1994) COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum. Cell 77, 895-907
18. Matsuoka, K., Orci, L., Amherdt, M., Bednarek, S. Y., Hamamoto, S., Schekman, R. and Yeung, T. (1998) COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes. Cell 93, 263-275
19. Kuge, O., Dascher, C., Orci, L., Rowe, T., Amherdt, M., Plutner, H., Ravazzola, M., Tanigawa, G., Rothman, J. E. and Balch, W. E. (1994) Sar1 promotes vesicle budding from the endoplasmic reticulum but not Golgi compartments. J. Cell Biol. 125, 51-65
20. Zilversmit, D. B. (1967) Formation and transport of chylomicrons. Fed. Proc. 26, 1599-1605
21. Kumar, N. S. and Mansbach, II, C. M. (1999) Prechylomicron transport vesicle: isolation and partial characterization. Am. J. Physiol. 276, G378-G386
22. Siddiqi, S. A., Gorelick, F. S., Mahan, J. T. and Mansbach, II, C. M. (2003) COPII proteins are required for Golgi fusion but not for endoplasmic reticulum budding of the pre-chylomicron transport vesicle. J. Cell Sci. 116, 415-427
23. Gusarova, V., Brodsky, J. L. and Fisher, E. A. (2003) Apolipoprotein B100 exit from the endoplasmic reticulum (ER) is COPII-dependent, and its lipidation to very low density lipoprotein occurs post-ER. J. Biol. Chem. 278, 48051-48058
24. Gibbons, G. F., Khurana, R., Odwell, A. and Seelaender, M. C. (1994) Lipid balance in HepG2 cells: active synthesis and impaired mobilization. J. Lipid Res. 35, 1801-1808
25. Tsai, J., Qiu, W., Kohen-Avramoglu, R. and Adeli, K. (2007) MEK-ERK inhibition corrects the defect in VLDL assembly in HepG2 cells: potential role of ERK in VLDL-ApoB100 particle assembly. Arterioscler. Thromb. Vasc. Biol. 27, 211-218
26. Hansson, P. K., Asztely, A. K., Clapham, J. C. and Schreyer, S. A. (2004) Glucose and fatty acid metabolism in McA-RH7777 hepatoma cells vs. rat primary hepatocytes: responsiveness to nutrient availability. Biochim. Biophys. Acta 1684, 54-62
27. Siddiqi, S. A., Mahan, J., Siddiqi, S., Gorelick, F. S. and Mansbach, II, C. M. (2006) Vesicle-associated membrane protein 7 is expressed in intestinal ER. J. Cell Sci. 119, 943-950
28. Swift, L. L. (1996) Role of the Golgi apparatus in the phosphorylation of apolipoprotein B. J. Biol. Chem. 271, 31491-31495
29. Moreau, P., Rodriguez, M., Cassagne, C., Morre, D. M. and Morre, D. J. (1991) Trafficking of lipids from the endoplasmic reticulum to the Golgi apparatus in a cell-free system from rat liver. J. Biol. Chem. 266, 4322-4328
30. Paulik, M., Nowack, D. D. and Morre, D. J. (1988) Isolation of a vesicular intermediate in the cell-free transfer of membrane from transitional elements of the endoplasmic reticulum to Golgi apparatus cisternae of rat liver. J. Biol. Chem. 263, 17738-17748
31. Kumar, N. S. and Mansbach, II, C. M. (1997) Determinants of triacylglycerol transport from the endoplasmic reticulum to the Golgi in intestine. Am. J. Physiol. 273, G18-G30
32. Neeli, I., Siddiqi, S. A., Siddiqi, S., Mahan, J., Lagakos, W. S., Binas, B., Gheyi, T., Storch, J. and Mansbach, II, C. M. (2007) Liver fatty acid-binding protein initiates budding of pre-chylomicron transport vesicles from intestinal endoplasmic reticulum. J. Biol. Chem. 282, 17974-17984
33. Siddiqi, S. A., Siddiqi, S., Mahan, J., Peggs, K., Gorelick, F. S. and Mansbach, II, C. M. (2006) The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle. J. Biol. Chem. 281, 20974-20982
34. Mukherjee, K., Siddiqi, S. A., Hashim, S., Raje, M., Basu, S. K. and Mukhopadhyay, A. (2000) Live Salmonella recruits N-ethylmaleimide- sensitive fusion protein on phagosomal membrane and promotes fusion with early endosome. J. Cell Biol. 148, 741-753
35. Chahil, T. J. and Ginsberg, H. N. (2006) Diabetic dyslipidemia. Endocrinol. Metab. Clin. North Am. 35, 491-510
36. Bergeron, J. J., Brenner, M. B., Thomas, D. Y. and Williams, D. B. (1994) Calnexin: a membrane-bound chaperone of the endoplasmic reticulum. Trends Biochem. Sci. 19, 124-128
37. Sztul, E. S., Howell, K. E. and Palade, G. E. (1983) Intracellular and transcellular transport of secretory component and albumin in rat hepatocytes. J. Cell Biol. 97, 1582-1591
38. Boren, J., Rustaeus, S. and Olofsson, S. O. (1994) Studies on the assembly of apolipoprotein B-100- and B-48-containing very low density lipoproteins in McA-RH7777 cells. J. Biol. Chem. 269, 25879-25888
39. Aridor, M. and Balch, W. E. (2000) Kinase signaling initiates coat complex II (COPII) recruitment and export from the mammalian endoplasmic reticulum. J. Biol. Chem. 275, 35673-35676
40. Ginsberg, H. N. (1995) Synthesis and secretion of apolipoprotein B from cultured liver cells. Curr. Opin. Lipidol. 6, 275-280
41. Xu, D., Joglekar, A. P., Williams, A. L. and Hay, J. C. (2000) Subunit structure of a mammalian ER/Golgi SNARE complex. J. Biol. Chem. 275, 39631-39639
42. Muniz, M. and Riezman, H. (2000) Intracellular transport of GPI-anchored proteins. EMBO J. 19, 10-15
43. Muniz, M., Morsomme, P. and Riezman, H. (2001) Protein sorting upon exit from the endoplasmic reticulum. Cell 104, 313-320
44. Stephens, D. J. and Pepperkok, R. (2002) Imaging of procollagen transport reveals COPI-dependent cargo sorting during ER-to-Golgi transport in mammalian cells. J. Cell Sci. 115, 1149-1160
45. Mironov, A. A., Mironov, Jr, A. A., Beznoussenko, G. V., Trucco, A., Lupetti, P., Smith, J. D., Geerts, W. J., Koster, A. J., Burger, K. N., Martone, M. E. et al. (2003) ER-to-Golgi carriers arise through direct en bloc protrusion and multistage maturation of specialized ER exit domains. Dev Cell 5, 583-594
46. Zuber, C., Cormier, J. H., Guhl, B., Santimaria, R., Hebert, D. N. and Roth, J. (2007) EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites. Proc. Natl. Acad. Sci. U.S.A. 104, 4407-4412
47. Schekman, R. and Mellman, I. (1997) Does COPI go both ways?. Cell 90, 197-200
48. Shimoni, Y., Kurihara, T., Ravazzola, M., Amherdt, M., Orci, L. and Schekman, R. (2000) Lst1p and Sec24p cooperate in sorting of the plasma membrane ATPase into COPII vesicles in Saccharomyces cerevisiae. J. Cell Biol. 151, 973-984