Identification of the domains in RXFP4 (GPCR142) responsible for the high affinity binding and agonistic activity of INSL5 at RXFP4 compared to RXFP3 (GPCR135)

European Journal of Pharmacology

Volumn 590, Issue 1-3, 2008, Pages 43-52

  Zhu, Jessica ^a   Kuei, Chester ^a   Sutton, Steven ^a   Kamme, Fredrik ^a   Yu, Jingxue ^a   Bonaventure, Pascal ^a   Atack, John ^a   Lovenberg, Timothy W ^a   Liu, Changlu ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

GPCR135; GPCR142; GPR100; INSL5 insulin like peptides 5 ; Relaxin 3; RXFP3; RXFP4; SALPR

Indexed keywords

CHIMERIC PROTEIN; G PROTEIN COUPLED RECEPTOR; INSULIN LIKE PEPTIDE 5; PROTEIN RXFP3; PROTEIN RXFP4; RELAXIN; RELAXIN 3; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRAIN COS7; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BINDING; SEQUENCE HOMOLOGY;

BINDING SITES; HUMANS; INSULIN; PROTEIN STRUCTURE, TERTIARY; PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RECOMBINANT FUSION PROTEINS; RELAXIN;

EID: 48049118575     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.05.025     Document Type: Article

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