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1
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33751100626
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The plant immune system
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Two excellent reviews providing a comprehensive overview of plant immunity. The authors introduce the concepts of PTI and ETI, and integrate them in the so-called 'zig-zag' model that underlies the arms-race occurring between plants and their pathogens.
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Jones J.D., and Dangl J.L. The plant immune system. Nature 444 (2006) 323-329. Two excellent reviews providing a comprehensive overview of plant immunity. The authors introduce the concepts of PTI and ETI, and integrate them in the so-called 'zig-zag' model that underlies the arms-race occurring between plants and their pathogens.
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(2006)
Nature
, vol.444
, pp. 323-329
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Jones, J.D.1
Dangl, J.L.2
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2
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32944479048
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Host-microbe interactions: shaping the evolution of the plant immune response
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Two excellent reviews providing a comprehensive overview of plant immunity. The authors introduce the concepts of PTI and ETI, and integrate them in the so-called 'zig-zag' model that underlies the arms-race occurring between plants and their pathogens.
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Chisholm S.T., Coaker G., Day B., and Staskawicz B.J. Host-microbe interactions: shaping the evolution of the plant immune response. Cell 124 (2006) 803-814. Two excellent reviews providing a comprehensive overview of plant immunity. The authors introduce the concepts of PTI and ETI, and integrate them in the so-called 'zig-zag' model that underlies the arms-race occurring between plants and their pathogens.
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(2006)
Cell
, vol.124
, pp. 803-814
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Chisholm, S.T.1
Coaker, G.2
Day, B.3
Staskawicz, B.J.4
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3
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35649023122
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Pathogen virulence factors as molecular probes of basic plant cellular functions
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A comprehensive review of effector functions within plant cells. It introduces the interesting idea of using effectors as molecular probes to investigate basic cellular functions.
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Bray Speth E., Lee Y.N., and He S.Y. Pathogen virulence factors as molecular probes of basic plant cellular functions. Curr Opin Plant Biol 10 (2007) 580-586. A comprehensive review of effector functions within plant cells. It introduces the interesting idea of using effectors as molecular probes to investigate basic cellular functions.
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(2007)
Curr Opin Plant Biol
, vol.10
, pp. 580-586
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Bray Speth, E.1
Lee, Y.N.2
He, S.Y.3
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4
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40149083472
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Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases
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The authors showed that the PRRs FLS2 and EFR are directly targeted by the bacterial effector AvrPto. The physical interactions of AvrPto and the PRRs require similar, but not identical, motifs in AvrPto to those involved in binding to the tomato resistance protein Pto. This physical interaction leads to the blockage of PTI and enhances susceptibility of the host plant.
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Xiang T., Zong N., Zou Y., Wu Y., Zhang J., Xing W., Li Y., Tang X., Zhu L., Chai J., et al. Pseudomonas syringae effector AvrPto blocks innate immunity by targeting receptor kinases. Curr Biol 18 (2008) 74-80. The authors showed that the PRRs FLS2 and EFR are directly targeted by the bacterial effector AvrPto. The physical interactions of AvrPto and the PRRs require similar, but not identical, motifs in AvrPto to those involved in binding to the tomato resistance protein Pto. This physical interaction leads to the blockage of PTI and enhances susceptibility of the host plant.
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(2008)
Curr Biol
, vol.18
, pp. 74-80
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Xiang, T.1
Zong, N.2
Zou, Y.3
Wu, Y.4
Zhang, J.5
Xing, W.6
Li, Y.7
Tang, X.8
Zhu, L.9
Chai, J.10
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5
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1642463788
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Innate immunity in plants and animals: striking similarities and obvious differences
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Nurnberger T., Brunner F., Kemmerling B., and Piater L. Innate immunity in plants and animals: striking similarities and obvious differences. Immunol Rev 198 (2004) 249-266
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(2004)
Immunol Rev
, vol.198
, pp. 249-266
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Nurnberger, T.1
Brunner, F.2
Kemmerling, B.3
Piater, L.4
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6
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33745770816
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Cellulose binding domains of a Phytophthora cell wall protein are novel pathogen-associated molecular patterns
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Gaulin E., Drame N., Lafitte C., Torto-Alalibo T., Martinez Y., Ameline-Torregrosa C., Khatib M., Mazarguil H., Villalba-Mateos F., Kamoun S., et al. Cellulose binding domains of a Phytophthora cell wall protein are novel pathogen-associated molecular patterns. Plant Cell 18 (2006) 1766-1777
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(2006)
Plant Cell
, vol.18
, pp. 1766-1777
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Gaulin, E.1
Drame, N.2
Lafitte, C.3
Torto-Alalibo, T.4
Martinez, Y.5
Ameline-Torregrosa, C.6
Khatib, M.7
Mazarguil, H.8
Villalba-Mateos, F.9
Kamoun, S.10
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7
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34547585772
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Invited review: priming, induction and modulation of plant defence responses by bacterial lipopolysaccharides
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Newman M.-A., Dow J.M., Molinaro A., and Parrilli M. Invited review: priming, induction and modulation of plant defence responses by bacterial lipopolysaccharides. J Endotoxin Res 13 (2007) 69-84
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(2007)
J Endotoxin Res
, vol.13
, pp. 69-84
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Newman, M.-A.1
Dow, J.M.2
Molinaro, A.3
Parrilli, M.4
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8
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36148958240
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Bacteria-derived peptidoglycans constitute pathogen-associated molecular patterns triggering innate immunity in Arabidopsis
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Gust A.A., Biswas R., Lenz H.D., Rauhut T., Ranf S., Kemmerling B., Gotz F., Glawischnig E., Lee J., Felix G., et al. Bacteria-derived peptidoglycans constitute pathogen-associated molecular patterns triggering innate immunity in Arabidopsis. J Biol Chem 282 (2007) 32338-32348
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(2007)
J Biol Chem
, vol.282
, pp. 32338-32348
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Gust, A.A.1
Biswas, R.2
Lenz, H.D.3
Rauhut, T.4
Ranf, S.5
Kemmerling, B.6
Gotz, F.7
Glawischnig, E.8
Lee, J.9
Felix, G.10
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9
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20444493980
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Plants and animals: a different taste for microbes?
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Zipfel C., and Felix G. Plants and animals: a different taste for microbes?. Curr Opin Plant Biol 8 (2005) 353-360
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(2005)
Curr Opin Plant Biol
, vol.8
, pp. 353-360
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Zipfel, C.1
Felix, G.2
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10
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33847237997
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A new method of defense response analysis using a transient expression system in rice protoplasts
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Takai R., Kaneda T., Isogai A., Takayama S., and Che F.S. A new method of defense response analysis using a transient expression system in rice protoplasts. Biosci Biotechnol Biochem 71 (2007) 590-593
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(2007)
Biosci Biotechnol Biochem
, vol.71
, pp. 590-593
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Takai, R.1
Kaneda, T.2
Isogai, A.3
Takayama, S.4
Che, F.S.5
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11
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45149090440
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A LysM receptor-like kinase plays a critical role in chitin signaling and fungal resistance in Arabidopsis
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Here CERK1/LysM-RLK1 is identified as a positive regulator of chitin signalling in Arabidopsis. Arabidopsis CERK1/LysM-RLK1 mutants are blocked in chitin-induced transcriptional reprogramming, which resembles transcriptional changes induced by other PAMPs. These mutants are also more susceptible to fungal pathogen. Furthermore, pre-treatment of plants with chitin induces resistance to fungal and bacterial pathogens.
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Wan J., Zhang X.C., Neece D., Ramonell K.M., Clough S., Kim S.Y., Stacey M.G., and Stacey G. A LysM receptor-like kinase plays a critical role in chitin signaling and fungal resistance in Arabidopsis. Plant Cell 20 (2008) 471-481. Here CERK1/LysM-RLK1 is identified as a positive regulator of chitin signalling in Arabidopsis. Arabidopsis CERK1/LysM-RLK1 mutants are blocked in chitin-induced transcriptional reprogramming, which resembles transcriptional changes induced by other PAMPs. These mutants are also more susceptible to fungal pathogen. Furthermore, pre-treatment of plants with chitin induces resistance to fungal and bacterial pathogens.
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(2008)
Plant Cell
, vol.20
, pp. 471-481
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Wan, J.1
Zhang, X.C.2
Neece, D.3
Ramonell, K.M.4
Clough, S.5
Kim, S.Y.6
Stacey, M.G.7
Stacey, G.8
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12
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33646847604
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Within-species flagellin polymorphism in Xanthomonas campestris pv. campestris and its impact on elicitation of Arabidopsis FLAGELLIN SENSING2-dependent defenses
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Sequence analysis of the flg22 epitope in different Xanthomonas campestris pv. campestris strains combined with elicitor activity studies showed that flg22 is more variable than previously anticipated.
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Sun W., Dunning F.M., Pfund C., Weingarten R., and Bent A.F. Within-species flagellin polymorphism in Xanthomonas campestris pv. campestris and its impact on elicitation of Arabidopsis FLAGELLIN SENSING2-dependent defenses. Plant Cell 18 (2006) 764-779. Sequence analysis of the flg22 epitope in different Xanthomonas campestris pv. campestris strains combined with elicitor activity studies showed that flg22 is more variable than previously anticipated.
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(2006)
Plant Cell
, vol.18
, pp. 764-779
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Sun, W.1
Dunning, F.M.2
Pfund, C.3
Weingarten, R.4
Bent, A.F.5
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13
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33846990935
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Friendly and dangerous signals: is the tissue in control?
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Matzinger P. Friendly and dangerous signals: is the tissue in control?. Nat Immunol 8 (2007) 11-13
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(2007)
Nat Immunol
, vol.8
, pp. 11-13
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Matzinger, P.1
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14
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34250621711
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Resistance to Botrytis cinerea induced in Arabidopsis by elicitors is independent of salicylic acid, ethylene, or jasmonate signaling but requires PHYTOALEXIN DEFICIENT3
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Ferrari S., Galletti R., Denoux C., De Lorenzo G., Ausubel F.M., and Dewdney J. Resistance to Botrytis cinerea induced in Arabidopsis by elicitors is independent of salicylic acid, ethylene, or jasmonate signaling but requires PHYTOALEXIN DEFICIENT3. Plant Physiol 144 (2007) 367-379
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(2007)
Plant Physiol
, vol.144
, pp. 367-379
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Ferrari, S.1
Galletti, R.2
Denoux, C.3
De Lorenzo, G.4
Ausubel, F.M.5
Dewdney, J.6
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15
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33947515118
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Phytotoxicity and innate immune responses induced by Nep1-like proteins
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The phytotoxin Nep1-like proteins of oomycetes trigger defence responses resembling those induced by flg22. This observation supports the idea of DAMP recognition and toxin-mediated immunity.
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Qutob D., Kemmerling B., Brunner F., Kufner I., Engelhardt S., Gust A.A., Luberacki B., Seitz H.U., Stahl D., Rauhut T., et al. Phytotoxicity and innate immune responses induced by Nep1-like proteins. Plant Cell 18 (2006) 3721-3744. The phytotoxin Nep1-like proteins of oomycetes trigger defence responses resembling those induced by flg22. This observation supports the idea of DAMP recognition and toxin-mediated immunity.
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(2006)
Plant Cell
, vol.18
, pp. 3721-3744
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Qutob, D.1
Kemmerling, B.2
Brunner, F.3
Kufner, I.4
Engelhardt, S.5
Gust, A.A.6
Luberacki, B.7
Seitz, H.U.8
Stahl, D.9
Rauhut, T.10
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16
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34447618237
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New insights into innate immunity in Arabidopsis
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This review summarises recent findings that recognition of the PAMP-induced endogenous peptides AtPep1 and its paralogues by the LRR-RLK PEPR1 activates plant defence and could provide a positive feedback loop mechanism to amplify PAMP-induced responses.
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Ryan C.A., Huffaker A., and Yamaguchi Y. New insights into innate immunity in Arabidopsis. Cell Microbiol 9 (2007) 1902-1908. This review summarises recent findings that recognition of the PAMP-induced endogenous peptides AtPep1 and its paralogues by the LRR-RLK PEPR1 activates plant defence and could provide a positive feedback loop mechanism to amplify PAMP-induced responses.
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(2007)
Cell Microbiol
, vol.9
, pp. 1902-1908
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Ryan, C.A.1
Huffaker, A.2
Yamaguchi, Y.3
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17
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39149099134
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Pattern-recognition receptors in plant innate immunity
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A recent review providing a detailed overview on known plant PRRs.
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Zipfel C. Pattern-recognition receptors in plant innate immunity. Curr Opin Immunol 20 (2008) 10-16. A recent review providing a detailed overview on known plant PRRs.
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(2008)
Curr Opin Immunol
, vol.20
, pp. 10-16
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Zipfel, C.1
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18
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33646525169
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Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation
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This paper reports the identification and characterisation of the LRR-RLK EFR as the EF-Tu receptor. Comparison of transcription profiles after elf18 or flg22 treatment showed a substantial overlap and led the authors to suggest signalling convergence downstream of individual PAMP recognition. It also showed that transformation of plant cells by the bacterium Agrobacterium tumefaciens is normally restricted by plant defences.
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Zipfel C., Kunze G., Chinchilla D., Caniard A., Jones J.D., Boller T., and Felix G. Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts Agrobacterium-mediated transformation. Cell 125 (2006) 749-760. This paper reports the identification and characterisation of the LRR-RLK EFR as the EF-Tu receptor. Comparison of transcription profiles after elf18 or flg22 treatment showed a substantial overlap and led the authors to suggest signalling convergence downstream of individual PAMP recognition. It also showed that transformation of plant cells by the bacterium Agrobacterium tumefaciens is normally restricted by plant defences.
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(2006)
Cell
, vol.125
, pp. 749-760
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Zipfel, C.1
Kunze, G.2
Chinchilla, D.3
Caniard, A.4
Jones, J.D.5
Boller, T.6
Felix, G.7
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19
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33644749576
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The Arabidopsis receptor kinase FLS2 binds flg22 and determines the specificity of flagellin perception
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The authors demonstrated that FLS2 is the flg22-binding site and provided recognition specificity between different flg22-derived peptides, proving that FLS2 is the flg22 PRR per se.
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Chinchilla D., Bauer Z., Regenass M., Boller T., and Felix G. The Arabidopsis receptor kinase FLS2 binds flg22 and determines the specificity of flagellin perception. Plant Cell 18 (2006) 465-476. The authors demonstrated that FLS2 is the flg22-binding site and provided recognition specificity between different flg22-derived peptides, proving that FLS2 is the flg22 PRR per se.
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(2006)
Plant Cell
, vol.18
, pp. 465-476
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Chinchilla, D.1
Bauer, Z.2
Regenass, M.3
Boller, T.4
Felix, G.5
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20
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37649023555
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CERK1, a LysM receptor kinase, is essential for chitin elicitor signaling in Arabidopsis
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Adopting a reverse genetic approach studying LysM RLKs in Arabidopsis the authors identified the receptor-like kinase CERK1/LysM-RLK1 as an essential signalling component for chitin responses in Arabidopsis. Furthermore, they showed that CERK1/LysM-RLK1 localises to the plasma membrane and possesses de novo kinase activity.
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Miya A., Albert P., Shinya T., Desaki Y., Ichimura K., Shirasu K., Narusaka Y., Kawakami N., Kaku H., and Shibuya N. CERK1, a LysM receptor kinase, is essential for chitin elicitor signaling in Arabidopsis. Proc Natl Acad Sci U S A 104 (2007) 19613-19618. Adopting a reverse genetic approach studying LysM RLKs in Arabidopsis the authors identified the receptor-like kinase CERK1/LysM-RLK1 as an essential signalling component for chitin responses in Arabidopsis. Furthermore, they showed that CERK1/LysM-RLK1 localises to the plasma membrane and possesses de novo kinase activity.
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(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19613-19618
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Miya, A.1
Albert, P.2
Shinya, T.3
Desaki, Y.4
Ichimura, K.5
Shirasu, K.6
Narusaka, Y.7
Kawakami, N.8
Kaku, H.9
Shibuya, N.10
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21
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33746582708
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Plant cells recognize chitin fragments for defense signaling through a plasma membrane receptor
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In an exhaustive biochemical study the LysM containing receptor-like protein CEBiP was identified as the chitin-binding PRR in rice. Plants silenced for CEBiP has reduced chitin binding and responsiveness. This is the first and only identified PRR in monocots.
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Kaku H., Nishizawa Y., Ishii-Minami N., Akimoto-Tomiyama C., Dohmae N., Takio K., Minami E., and Shibuya N. Plant cells recognize chitin fragments for defense signaling through a plasma membrane receptor. Proc Natl Acad Sci U S A 103 (2006) 11086-11091. In an exhaustive biochemical study the LysM containing receptor-like protein CEBiP was identified as the chitin-binding PRR in rice. Plants silenced for CEBiP has reduced chitin binding and responsiveness. This is the first and only identified PRR in monocots.
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(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 11086-11091
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Kaku, H.1
Nishizawa, Y.2
Ishii-Minami, N.3
Akimoto-Tomiyama, C.4
Dohmae, N.5
Takio, K.6
Minami, E.7
Shibuya, N.8
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22
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34250158101
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Molecular identification and characterization of the tomato flagellin receptor LeFLS2, an orthologue of Arabidopsis FLS2 exhibiting characteristically different perception specificities
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Tomato is a species extremely sensitive to flagellin and with distinct recognition specificities compared to Arabidopsis. This paper reports the cloning of the tomato LeFLS2 based on sequence similarity with AtFLS2, complementation of Arabidopsis fls2 mutant and binding to assays.
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Robatzek S., Bittel P., Chinchilla D., Kochner P., Felix G., Shiu S.H., and Boller T. Molecular identification and characterization of the tomato flagellin receptor LeFLS2, an orthologue of Arabidopsis FLS2 exhibiting characteristically different perception specificities. Plant Mol Biol 64 (2007) 539-547. Tomato is a species extremely sensitive to flagellin and with distinct recognition specificities compared to Arabidopsis. This paper reports the cloning of the tomato LeFLS2 based on sequence similarity with AtFLS2, complementation of Arabidopsis fls2 mutant and binding to assays.
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(2007)
Plant Mol Biol
, vol.64
, pp. 539-547
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Robatzek, S.1
Bittel, P.2
Chinchilla, D.3
Kochner, P.4
Felix, G.5
Shiu, S.H.6
Boller, T.7
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23
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33846896457
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Early events in the pathogenicity of Pseudomonas syringae on Nicotiana benthamiana
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The authors identified the FLS2 orthologue in N. benthamiana and showed that NbFLS2 silencing enhances susceptibility to a range of adapted and non-adapted bacteria. Furthermore, the two bacterial effectors AvrPto and AvrPtoB suppress PTI when transiently expressed in N. benthamiana leading to enhanced bacterial susceptibility.
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Hann D.R., and Rathjen J.P. Early events in the pathogenicity of Pseudomonas syringae on Nicotiana benthamiana. Plant J 49 (2007) 607-618. The authors identified the FLS2 orthologue in N. benthamiana and showed that NbFLS2 silencing enhances susceptibility to a range of adapted and non-adapted bacteria. Furthermore, the two bacterial effectors AvrPto and AvrPtoB suppress PTI when transiently expressed in N. benthamiana leading to enhanced bacterial susceptibility.
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(2007)
Plant J
, vol.49
, pp. 607-618
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Hann, D.R.1
Rathjen, J.P.2
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24
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37249018540
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Identification and mutational analysis of Arabidopsis FLS2 leucine-rich repeat domain residues that contribute to flagellin perception
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Combining mutational, phylogenetic and structural modelling approaches, the authors showed that the AtFLS2 LRR domains 9-15 contributed significantly to flg22 binding.
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Dunning F.M., Sun W., Jansen K.L., Helft L., and Bent A.F. Identification and mutational analysis of Arabidopsis FLS2 leucine-rich repeat domain residues that contribute to flagellin perception. Plant Cell 19 (2007) 3297-3313. Combining mutational, phylogenetic and structural modelling approaches, the authors showed that the AtFLS2 LRR domains 9-15 contributed significantly to flg22 binding.
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(2007)
Plant Cell
, vol.19
, pp. 3297-3313
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Dunning, F.M.1
Sun, W.2
Jansen, K.L.3
Helft, L.4
Bent, A.F.5
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25
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33644780918
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Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis
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Robatzek S., Chinchilla D., and Boller T. Ligand-induced endocytosis of the pattern recognition receptor FLS2 in Arabidopsis. Genes Dev 20 (2006) 537-542
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(2006)
Genes Dev
, vol.20
, pp. 537-542
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Robatzek, S.1
Chinchilla, D.2
Boller, T.3
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26
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36248946572
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Ligand-dependent reduction in the membrane mobility of FLAGELLIN SENSITIVE2, an Arabidopsis receptor-like kinase
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Ali G.S., Prasad K.V., Day I., and Reddy A.S. Ligand-dependent reduction in the membrane mobility of FLAGELLIN SENSITIVE2, an Arabidopsis receptor-like kinase. Plant Cell Physiol 48 (2007) 1601-1611
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(2007)
Plant Cell Physiol
, vol.48
, pp. 1601-1611
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Ali, G.S.1
Prasad, K.V.2
Day, I.3
Reddy, A.S.4
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27
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34547151023
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A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence
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In a reverse-genetic approach focussed on LRR-RLK genes rapidly induced by flg22, the authors found that plants mutated in BAK1, a gene involved in brassinosteroid signalling, are strongly affected in flg22 and partially in elf18 responses. Although, BAK1 is dispensable for flg22 binding, BAK1 and FLS2 rapidly interact in a ligand-dependent manner.
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Chinchilla D., Zipfel C., Robatzek S., Kemmerling B., Nurnberger T., Jones J.D., Felix G., and Boller T. A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence. Nature 448 (2007) 497-500. In a reverse-genetic approach focussed on LRR-RLK genes rapidly induced by flg22, the authors found that plants mutated in BAK1, a gene involved in brassinosteroid signalling, are strongly affected in flg22 and partially in elf18 responses. Although, BAK1 is dispensable for flg22 binding, BAK1 and FLS2 rapidly interact in a ligand-dependent manner.
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(2007)
Nature
, vol.448
, pp. 497-500
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Chinchilla, D.1
Zipfel, C.2
Robatzek, S.3
Kemmerling, B.4
Nurnberger, T.5
Jones, J.D.6
Felix, G.7
Boller, T.8
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28
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34547193514
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The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants
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Using a proteomic approach, the authors also identified BAK1 as a FLS2 interactor and positive regulator of flg22 signalling. Interestingly, silencing of NbBAK1 in Nicotiana benthamiana decreases responsiveness not only to flg22 but also to the PAMPs CSP22 and INF1. NbBAK1-silenced plants are also more susceptible to a range of bacteria and a biotrophic oomycete.
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Heese A., Hann D.R., Gimenez-Ibanez S., Jones A.M., He K., Li J., Schroeder J.I., Peck S.C., and Rathjen J.P. The receptor-like kinase SERK3/BAK1 is a central regulator of innate immunity in plants. Proc Natl Acad Sci U S A 104 (2007) 12217-12222. Using a proteomic approach, the authors also identified BAK1 as a FLS2 interactor and positive regulator of flg22 signalling. Interestingly, silencing of NbBAK1 in Nicotiana benthamiana decreases responsiveness not only to flg22 but also to the PAMPs CSP22 and INF1. NbBAK1-silenced plants are also more susceptible to a range of bacteria and a biotrophic oomycete.
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(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 12217-12222
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Heese, A.1
Hann, D.R.2
Gimenez-Ibanez, S.3
Jones, A.M.4
He, K.5
Li, J.6
Schroeder, J.I.7
Peck, S.C.8
Rathjen, J.P.9
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29
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34848822851
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Multiple mechanisms modulate brassinosteroid signaling
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Gendron J.M., and Wang Z.-Y. Multiple mechanisms modulate brassinosteroid signaling. Curr Opin Plant Biol 10 (2007) 436-441
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(2007)
Curr Opin Plant Biol
, vol.10
, pp. 436-441
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Gendron, J.M.1
Wang, Z.-Y.2
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30
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34250803478
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The BRI1-associated kinase 1, BAK1, has a brassinolide-independent role in plant cell-death control
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The authors showed that BAK1 is a negative regulator of cell death. BAK1 mutants have enhanced runaway cell death upon bacterial infection with Pto DC3000 without changes in the disease susceptibility. However, this loss of cell death control enhances susceptibility to necrotrophic fungi. Similar to the above studies, the effects of BAK1 are brassinosteroid-independent, revealing that BAK1 controls signalling triggered by several different LRR-RLKs.
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Kemmerling B., Schwedt A., Rodriguez P., Mazzotta S., Frank M., Qamar S.A., Mengiste T., Betsuyaku S., Parker J.E., Mussig C., et al. The BRI1-associated kinase 1, BAK1, has a brassinolide-independent role in plant cell-death control. Curr Biol 17 (2007) 1116-1122. The authors showed that BAK1 is a negative regulator of cell death. BAK1 mutants have enhanced runaway cell death upon bacterial infection with Pto DC3000 without changes in the disease susceptibility. However, this loss of cell death control enhances susceptibility to necrotrophic fungi. Similar to the above studies, the effects of BAK1 are brassinosteroid-independent, revealing that BAK1 controls signalling triggered by several different LRR-RLKs.
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(2007)
Curr Biol
, vol.17
, pp. 1116-1122
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Kemmerling, B.1
Schwedt, A.2
Rodriguez, P.3
Mazzotta, S.4
Frank, M.5
Qamar, S.A.6
Mengiste, T.7
Betsuyaku, S.8
Parker, J.E.9
Mussig, C.10
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