Inhibitors of human dihydrofolate reductase: A computational design and docking studies using glide

E-Journal of Chemistry

Volumn 5, Issue 2, 2008, Pages 263-270

  Yamini, Lingala ^a   Vijjulatha, Manga ^a  

^a OSMANIA UNIVERSITY   (India)

Author keywords

ADME (Absorption, Distribution, Metabolism and Elimination); Dihydrofolate reductase (DHFR); Docking

Indexed keywords

EID: 47949123874     PISSN: None     EISSN: 09734945     Source Type: Journal    
DOI: 10.1155/2008/401738     Document Type: Article

References (12)

1. Suckling C. J., Enzyme chemistry, Chapman and Hall Ltd., New York, 1984, 121.
2. Thomas A. Halgren, MMFF VI. J. Comput. Chem., 1999, 20, 720.
3. th Congress of the world association of theoretically oriented chemists
4. Richard A. Friesner, Jay L. Banks, Robert B. Murphy, Thomas A. Halgren, Jasna J. Klicic, Daniel T. Mainz, Mathew P. Repasky, Eric H. Knoll, Mea Shelly, Jason K. Perry, David E. Shaw, Perry Francis and Peter S. She kin. J.Med.Chem. 2004, 47, 1739.
5. Taverna DM and Goldstein RA. Proteins , 2002, 46, 105.
6. Blaney J. M., Hansch C., Silipo C and Vittoria A., Chem. Rev. 1984, 84, 333
7. Kuntz I.D, Science, 1992, 257, 1078.
8. Gangjee A., Devraj R and Queener S.F, J.Med.Chem., 1997, 40, 470.
9. A. Rosowsky V, Cody N Galstay, Hanging A T, Papoulis and Queener S F, J.Med.Chem, 1999, 42, 4853.
10. Gangjee A, Vidwans A P, Vasudevan A, Queener S F, J. Med. Chem.,1998, 41, 3426
11. Schrödinger LLC, New York , 2005, Glide 4.0
12. Greedy J E ,Adv. Pharmacol. Chemother. 1980, 17, 37.