Protective effect of pinitol against D-galactosamine-induced hepatotoxicity in rats fed on a high-fat diet

Bioscience, Biotechnology and Biochemistry

Volumn 72, Issue 7, 2008, Pages 1657-1666

  Zhou, Yusi ^a   Park, Chung Mu ^a   Cho, Chung Won ^a   Song, Young Sun ^a  

^a Inje University   (South Korea)

Author keywords

D galactosamine; Hepatotoxicity; Pinitol; Rat; Tumor necrosis factor alpha (TNF )

Indexed keywords

ALANINE AMINOTRANSFERASE (ALAAT); AMINOTRANSFERASE; ASPARTATE (ASP); D-GALACTOSAMINE; HEPATOTOXICITY; HIGH-FAT DIET; LIVER DAMAGE; PROTECTIVE EFFECT (PE); SINGLE DOSE; SPRAGUE DAWLEY RATS; TUMOR NECROSIS FACTOR (NCF);

DRUG DERIVATIVE; GALACTOSAMINE; INOSITOL; LIPID; PINITOL; PROTECTIVE AGENT;

ANIMAL; ARTICLE; BLOOD; ENZYME ASSAY; INFLAMMATION; MALE; OXIDATIVE STRESS; RAT; SPRAGUE DAWLEY RAT; TOXIC HEPATITIS;

ANIMALS; CLINICAL ENZYME TESTS; GALACTOSAMINE; HEPATITIS, TOXIC; INFLAMMATION; INOSITOL; LIPIDS; MALE; OXIDATIVE STRESS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 47949105831     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.70473     Document Type: Article

References (41)

1. Keppler, D., Lesch, R., Reutter, W., and Decker, K., Experimental hepatitis induced by D-galactosamine. Exp. Mol. Pathol., 9, 279-290 (1968).
2. Decker, K., and Keppler, D., Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death. Rev. Physiol. Biochem. Pharmacol., 71, 77-106 (1974).
3. Halliwel, B., and Gutteridge, J. M. C., "Free Radicals in Biology and Medicine" 3rd ed., Oxford University Press, New York, pp. 335-336 (1999).
4. Kasravi, F. B., Wang, L., Wang, D., Molin, G., Bengmark, S., and Jeppsson, B., Bacterial translocation in acute liver injury induced by D-galactosamine. Hepatology, 23, 97-103 (1996).
5. Silverstein, R., D-galactosamine lethality model: scope and limitations. J. Endotoxin Res., 10, 147-162 (2004).
6. Stachlewitz, R. F., Seabra, V., Bradford, B., Bradham, C. A., Rusy, I., Germolec, D., and Thurman, R. G., Glycine and uridine prevent D-galactosamine hepatotoxicity in the rats: role of Kupffer cell. Hepatology, 29, 737-745 (1999).
7. Keppler, D., and Decker, K., Studies on the mechanism of galactosamine-1-phosphate and its inhibition of UDP-glucose pyrophosphorylase. Eur. J. Biochem., 10, 219-225 (1969).
8. Leist, M., Gantner, F., Bohlinger, I., Germann, P. G., Tiegs, G., and Wendel, A., Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha required transcriptional arrest. J. Immunol., 153, 1778-1788 (1994).
9. Narayan, C. R., Joshi, D. D., Craig, J., Mudjumdar, A. M., and Dhekne, V. V., Pinitol, a new antidiabetic compound from the leaves of Bougainvillea pectabilis. Curr. Sci., 56, 139-141 (1987).
10. Bates, S. H., Jones, R. B., and Bailey, C. J., Insulin-like effect of pinitol. Br. J. Pharmacol., 130, 1944-1948 (2000).
11. Davis, A., Christiansen, M., Horowitz, J. F., Klein, S., Hellerstein, M. K., and Ostlund, R. E., Effect of pinitol treatment on insulin action in subjects with insulin resistance. Diabetes Care, 23, 1000-1005 (2000).
12. Shin, Y. C., and Jeon, J. Y., The physiological activities of pinitol isolated from soybean. Food Ind. Nutr., 30, 2680-2688 (2004).
13. Kim, J. C., Shin, J. Y., Shin, D. H., Kim, S. H., Park, S. H., Park, R. D., Park, S. C., Kim, Y. B., and Shin, Y. C., Synergistic anti-inflammatory effects of pinitol and glucosamine in rats. Phytother. Res., 19, 1048-1051 (2005).
14. Kim, J. I., Kim, J. C., Kang, M. J., Lee, M. S., Kim, J. J., and Cha, I. J., Effects of pinitol isolated from soybeans on glycemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study. Eur. J. Clin. Nutr., 59, 456-458 (2005).
15. Lee, J. S., Lee, C. M., Jeong, Y. I., Jung, I. D., Kim, B. H., Seong, E. Y., Kim, J. I., Choi, I. W., Chung, H. Y., and Park, Y. M., D-pinitol regulates Th1/Th2 balance via suppressing Th2 immune response in ovalbumin-induced asthma. FEBS Lett., 581, 57-64 (2007).
16. Kazuo, K., Akie, M., Yoshinobu, M., and Toshichika, T., Effect of caffeine on the body fat and lipid metabolism of rats fed on a high-fat diet. Biosci. Biotechnol. Biochem., 69, 2219-2223 (2005).
17. Hill, J. O., Lin, D., Yakubu, F., and Peters, J. C., Development of dietary obesity in rats: influence of amount and composition of dietary fat. Int. J. Obes. Relat. Metab. Disord., 16, 321-333 (1992).
18. Huang, B. W., Chiang, M. T., Yao, H. T., and Chiang, W., The effect of high-fat and high-fructose diets on glucose tolerance and plasma lipid and leptin levels in rats. Diabetes Obes. Metab., 6, 120-126 (2004).
19. Yang, S. H., Lin, H. Z., Lane, M. D., Clemens, M., and Diehl, A. M., Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohapatitis. Proc. Natl. Acad. Sci. USA, 94, 2557-2562 (1997).
20. Folch, I., Lees, M., and Stanley, S. G. H., A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem., 226, 497-509 (1957).
21. Fraga, C. G., Leibovitz, R. M., and Tappel, A. L., Lipid peroxidation measured as thiobarbituric-reactive substances in tissue slices: characterization and comparision with homogenates and microsomes. Free Radic. Biol. Med., 4, 155-161 (1988).
22. Summer, K. H., and Greim, H., Detoxification of chloroprene (2-chloro-1,3-butadiene) with glutathione in the rat. Biochem. Biophys. Res. Commun., 96, 566-573 (1980).
23. Bradford, M. M., A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254 (1976).
24. Oyanagui, Y., Reevaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal. Biochem., 142, 290-296 (1984).
25. Abei, H., Catalase in vitro. Methods Enzymol., 105, 121-126 (1984).
26. Paglia, D. E., and Valentine, W. N., Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med., 70, 158-169 (1967).
27. Richterich, R., Glutathione reductase. Clin. Chem., 2, 366-367 (1971).
28. Lim, H. K., Kim, H. S., Choi, H. S., and Choi, J. W., Protective and therapeutic effects of Malloti cortex extract on carbon tetrachloride- and galactosamine-induced hepatotoxicity in rats. J. Appl. Pharmacol., 7, 35-43 (1999).
29. Mourelle, M., and Meza, M. A., Colchicine prevents D- galactosamine-induced hepatitis. J. Hepatol., 8, 165-172 (1989).
30. "Committee on Diet and Health Food and Nutrition Board, Diet and Health," National Academy Press, Washington, DC, pp. 159-258 (1989).
31. Brattin, W. J., Glende, Jr., E. A., and Recknagel, R. O., Pathological mechanisms in carbon tetrachloride hepatotoxicity. J. Free Radic. Biol. Med., 1, 27-38 (1985).
32. Recknagel, R. O., Glende, Jr., E. A., Dolak, J. A., and Waller, R. L., Mechanisms of carbon tetrachloride toxicity. Pharmacol. Ther., 43, 139-154 (1989).
33. Poli, G., Chiarpotto, E., Albano, E., Cottalasso, D., Nanni, G., Marinari, U. M., Bassi, A. M., and Dianzani, M. U., Carbon tetrachloride-induced inhibition of hepatocyte lipoprotein secretion: functional impairment of Golgi apparatus in the early phases of such injury. Life Sci., 36, 533-539 (1985).
34. Boll, M., Weber, L. W., Becker, E., and Stampfl, A., Pathogenesis of carbon tetrachloride-induced hepatocyte injury bioactivation of CCl4 by cytochrome P450 and effects on lipid homeostasis. Z. Naturforsch., 56, 111-121 (2001).
35. Nishida, K., Ohta, Y., and Ishiguro, I., Preventive effect of gamma-glutamylcysteinylethyl ester on carbon tetrachloride-induced hepatic triglyceride accumulation in rats. Toxicol. Lett., 95, 141-146 (1998).
36. Hu, H. L., and Chen, R. D., Changes in free radicals trace elements and neurophysiological function in rats with liver damage induced by D-galactosamine. Biol. Trace Elem. Res., 34, 19-25 (1992).
37. Mangeney-Andreani, M., Sire, O., Montagne-Clavel, J., Nordmann, R., and Nodmann, J., Inhibitory effect of D-galactosamine administration on fatty acid oxidation in rat hepatocytes. FEBS Lett., 145, 267-270 (1982).
38. Han, K. H., Hashimoto, N., Shimada, K., Sekikawa, M., Noda, T., Yamauchi, H., Hashimoto, M., Chiji, H., Topping, D., and Fukushima, M., Hepatoprotective effect of purple potato extract against D-galactosamine induced liver injury in rats. Biosci. Biotechnol. Biochem., 70, 1432-1437 (2006).
39. Sinclair, A. J., Barnett, A. H., and Lunie, J., Free radical and auto-oxidant systems in health and disease. Br. J. Hosp. Med., 17, 409 (1991).
40. Kim, J. I., Kim, J. C., Kang, M. J., Lee, M. S., Kim, J. J., and Cha, I. J., Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study. Eur. J. Clin. Nutr., 59, 456-458 (2005).
41. Halliwel, B., and Gutteridge, J. M. C., "Free Radicals in Biology and Medicine" 3rd ed., Oxford University Press, New York, pp. 14-17 (1999).