Evaluation of pharmacokinetics and pharmacodynamics of captopril from transdermal hydrophilic gels in normotensive rabbits and spontaneously hypertensive rats

International Journal of Pharmaceutics

Volumn 209, Issue 1-2, 2000, Pages 87-94

  Wu, Pao Chu ^a   Huang, Yaw Bin ^a   Chang, Judy Jui Fen ^a   Chang, Jui Sheng ^a   Tsai, Yi Hung ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Blood pressure; Captopril; Heart rate; Pharmacokinetics; Plasma renin activity; Spontaneously hypertensive rat

Indexed keywords

CAPTOPRIL;

ADOLESCENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFECT; DRUG FORMULATION; DRUG RELEASE; GEL; HEART RATE; HYDROPHILICITY; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RABBIT; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ADMINISTRATION, CUTANEOUS; ALGORITHMS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CAPTOPRIL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GELS; HEART RATE; INJECTIONS, INTRAVENOUS; MALE; MODELS, BIOLOGICAL; RABBITS; RATS; RATS, INBRED SHR; RENIN;

EID: 0034687575     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00557-3     Document Type: Article

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