Syrian hamster embryo (SHE) cell transformation assay with conditioned media (without X-ray irradiated feeder layer) using 2,4-diaminotoluene, 2,6-diaminotoluene and chloral hydrate

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 654, Issue 2, 2008, Pages 108-113

  Pant, Kamala ^a   Sly, Jamie E ^a   Bruce, Shannon W ^a   Leung, Cleo ^a   San, Richard H C ^a  

^a Genetic Toxicology Department   (United States)

Author keywords

2,6 Diaminotoluene; Chloral hydrate; Conditioned media; Morphological transformation; SHE cell transformation without feeder cells 2,4 diaminotoluene

Indexed keywords

2,4 DIAMINOTOLUENE; 2,6 DIAMINOTOLUENE; BENZO[A]PYRENE; CHLORAL HYDRATE;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CELL TRANSFORMATION; CONTROLLED STUDY; EMBRYO CELL; NONHUMAN; PRIORITY JOURNAL; SYRIAN HAMSTER; TOXICITY TESTING;

ANIMALS; CARCINOGENICITY TESTS; CELL CULTURE TECHNIQUES; CELL TRANSFORMATION, NEOPLASTIC; CHLORAL HYDRATE; CRICETINAE; CULTURE MEDIA, CONDITIONED; EMBRYO, MAMMALIAN; MESOCRICETUS; PHENYLENEDIAMINES; X-RAYS;

BOVINAE; MESOCRICETUS AURATUS;

EID: 47849112362     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2008.05.006     Document Type: Article

References (5)

1. Isfort R.J., Cody D.B., Doerson C., Kerckaert G.A., and LeBoeu R.A. Alteration in cellular differentiation, mitogenesis, cytoskeleton and growth characteristics during Syrian hamster embryo cell multistep in vitro transformation. Int. J. Cancer 59 (1994) 114-125
2. LeBoeuf R.A., Kerckaert G.A., Aardema M.J., Gibson D.P., Brauninger R., and Isfort R.J. The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals. Mutat. Res. 356 (1996) 85-127
3. Pant K., Harvey J.S., and San R. What should the testing strategy be when the test material is more toxic to feeder cells than to target cells in the Syrian hamster embryo (SHE) cell transformation assay?. Mutat. Res. 577 Suppl. 1 (2005) 42
4. Pant K., Sly J.E., Emory B.R., Bruce S.W., and San R. Is X-ray irradiation of feeder cells necessary for Syrian hamster embryo (SHE) cell transformation assay?. Mutat. Res. 577 Suppl. 1 (2005) 182
5. Pant K., and Aardema M.J. The Syrian hamster embryo (SHE) low pH cell transformation assay. Altern. Methodol. Toxicol. 1 Suppl. 35 (2008) 20.3.1-20.3.16