Infected cell killing by HIV-1 protease promotes NF-κB dependent HIV-1 replication

PLoS ONE

Volumn 3, Issue 5, 2008, Pages

  Bren, Gary D ^a   Whitman, Joe ^a   Cummins, Nathan ^a   Shepard, Brett ^a   Rizz, Stacey A ^a   Trushin, Sergey A ^a   Badley, Andrew D ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROCASPASE 8; PROTEINASE; TOLL LIKE RECEPTOR; P16 PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1;

APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; LYMPHOCYTE FUNCTION; NONHUMAN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; VIRUS ACTIVATION; VIRUS CELL INTERACTION; VIRUS REPLICATION; VIRUS SURVIVAL; CELL SURVIVAL; CYTOLOGY; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; LEUKEMIA CELL LINE; LONG TERMINAL REPEAT; METABOLISM; PHYSIOLOGY; PLASMID; REPORTER GENE; T LYMPHOCYTE; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

APOPTOSIS; CASPASE 8; CD4-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; ENZYME ACTIVATION; GENES, REPORTER; HIV LONG TERMINAL REPEAT; HIV PROTEASE; HIV-1; HUMANS; JURKAT CELLS; NF-KAPPA B; PLASMIDS; T-LYMPHOCYTES; TRANSFECTION; VIRUS REPLICATION;

EID: 47749152622     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002112     Document Type: Article

References (16)

1. Nie Z, McNamara D, Badley AD (2006) HIV Protease and Cell Death. In: Badley AD, ed. Cell Death During HIV Infection. Boca Raton: Taylor and Francis Press. pp 421-437.
2. Nie Z, Phenix BN, Lunt JJ, Alam A, Lynch DH, et al. (2002) HIV-1 protease processes procaspase 8 to cause mitochondrial release of cytochrome c, caspase cleavage and nuclear fragmentation. Cell Death Differ 9: 1172-1184.
3. Nie Z, Bren GD, Vlahakis SR, Schimnich AA, Brenchley JM, et al. (2007) Human immunodeficiency virus type 1 protease cleaves procaspase 8 in vivo. J Virol 81: 6947-6956.
4. Lemniers B, Salmena L, Bidere N, Su H, Matysiak-Zablocki E, et al. (2007) Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling. J Biol Chem 282: 7416-7423.
5. Su H, Bidere N, Zheng L, Cubre A, Sakai K, et al. (2005) Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science 307: 1465-1468.
6. Bidere N, Snow AL, Sakai K, Zheng L, Lenardo MJ (2006) Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation. Curr Biol 16: 1666-1671.
7. Kataoka T, Tschopp J (2004) N-terminal fragment of c-FLIP(L) processed by caspsuse 8 specifically interacts with TRAF2 and induces activation of the NF-kappaB signaling pathway. Mol Cell Biol 24: 2627-2636.
8. Golks A, Brenner D, Krammer PH, Lavrik IN (2006) The c-FLIP-NH2 terminus (p22-FLIP) induces NF-kappaB activation. J Exp Med 203: 1295-1305.
9. Cohen L, Henzel M, Baeuerle PA (1998) IKAP is a scaffold protein of the IkappaB kinase complex. Nature 395: 292-296.
10. Duh EJ, Maury WJ, Folks TM, Fauci AS, Rabson AB (1989) Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat. Proc Natl Acad Sci U S A 86: 5974-5978.
11. McElhinny JA, MacMorran WS, Bren GD, Ten RM, Israel A, et al. (1995) Regulation of I kappa B alpha and p105 in monocytes and macrophages persistently infected with human immunodeficiency virus. J Virol 69: 1500-1509.
12. Gil J, Bermejo M, Alcami J (2004) HIV and apoptosis: a complex interaction between cell death and virus survival. Prog Mol Subcell Biol 36: 117-149.
13. Cicala C, Arthos J, Selig SM, Dennis G Jr., Hosark DA, et al. (2002) HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication. Proc Natl Acad Sci U S A 99: 9380-9385.
14. Nie Z, Bren GD, Rizza SA, Badley AD (2008) HIV Protease Cleavage of Procaspase 8 is Necessary for Death of HIV-infected Cells. The Open Virology Journal 2: 1-7.
15. Perez VL, Rowe T, Justement JS, Butera ST, June CH, et al. (1991) AD IRV-1-infected T cell done defective in II-2 production and Ca2+ mobilization after CD3 stimulation. J Immunol 147: 3145-3148.
16. Swingler S, Mann AM, Zhou J, Swingler C, Stevenson M (2007) Apoptotic killing of HIV-1-infected macrophages is subverted by the viral envelope glycoprotein. PLoS Pathog 3: 1281-1290.