Therapies for steroid-resistant nephrotic syndrome

Pediatric Nephrology

Volumn 23, Issue 9, 2008, Pages 1391-1394

  Hodson, Elisabeth M ^a,b   Craig, Jonathan C ^a,b  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cyclophosphamide; Cyclosporin; Focal and segmental glomerulosclerosis; Minimal change disease; Randomised controlled trials

Indexed keywords

ADALIMUMAB; ALKYLATING AGENT; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOPHOSPHAMIDE; CYCLOSPORIN; DEXAMETHASONE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; INDOMETACIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PLACEBO; PODOCIN; PREDNISONE; RITUXIMAB; ROSIGLITAZONE; STEROID; TACROLIMUS;

AGE DISTRIBUTION; CHILD HEALTH CARE; CHRONIC KIDNEY FAILURE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; DRUG EFFICACY; DRUG MEGADOSE; DRUG PULSE THERAPY; DRUG RESPONSE; DRUG SAFETY; EDITORIAL; ETHNIC DIFFERENCE; EVIDENCE BASED MEDICINE; FOCAL GLOMERULOSCLEROSIS; HIGH RISK POPULATION; HUMAN; HYPERTENSION; KIDNEY FUNCTION; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MINIMAL CHANGE GLOMERULONEPHRITIS; MONOTHERAPY; NEPHROTIC SYNDROME; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEINURIA; REMISSION; SIDE EFFECT; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT;

ADRENAL CORTEX HORMONES; CHILD; CYCLOPHOSPHAMIDE; CYCLOSPORINE; DRUG RESISTANCE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MUTATION; NEPHROTIC SYNDROME; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 47749145749     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-008-0792-3     Document Type: Editorial

References (38)

1. McKinney PA, Feltbower RG, Brocklebank JT, Fitzpatrick MM (2001) Time trends and ethnic patterns of childhood nephrotic syndrome in Yorkshire, UK. Pediatr Nephrol 16:1040-1044
2. Wong W (2007) Idiopathic nephrotic syndrome in New Zealand children, demographic, clinical features, initial management and outcome after twelve-month follow-up: Results of a three-year national surveillance study. J Paediatr Child Health 43:337-341
3. Tarshish P, Tobin JN, Bernstein J, Edelmann CM Jr (1997) Prognostic significance of the early course of minimal change nephrotic syndrome: report of the International Study of Kidney Disease in Children. J Am Soc Nephrol 8:769-776
4. Kim JS, Bellew CA, Silverstein DM, Aviles DH, Boineau FG, Vehaskari VM (2005) High incidence of initial and late steroid resistance in childhood nephrotic syndrome. Kidney Int 68:1275-1281
5. International Study of Kidney Disease in Children (1981) The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children. J Pediatr 98:561-564
6. Borges FF, Shiraichi L, da Silva MP, Nishimoto EI, Nogueira PC (2007) Is focal segmental glomerulosclerosis increasing in patients with nephrotic syndrome? Pediatr Nephrol 22:1309-1313
7. Ruf RG, Lichtenberger A, Karle SM, Haas JP, Anacleto FE, Schultheiss M, Zalewiski I, Imm A, Ruf EM, Mucha B, Bagga A, Neuhaus T, Fuchshuber A, Bakkaloglu A, Hildebrandt F (2004) Patients with mutations in NPHS2 (podocin) do not respond to standard steroid treatment of nephrotic syndrome. J Am Soc Nephrol 15:722-732
8. Weber S, Gribouval O, Esquivel EL, Morinière V, Tête MJ, Legendre C, Niaudet P, Antignac C (2004) NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence. Kidney Int 66:571-579
9. Berdeli A, Mir S, Yavascan O, Serdaroglu E, Bak M, Aksu N, Oner A, Anarat A, Donmez O, Yildiz N, Sever L, Tabel Y, Dusunsel R, Sonmez F, Cakar N (2007) NPHS2 (podicin) mutations in Turkish children with idiopathic nephrotic syndrome. Pediatr Nephrol 22:2031-2040
10. Ehrich JH, Geerlings C, Zivicnjak M, Franke D, Geerlings H, Gellermann J (2007) Steroid-resistant idiopathic childhood nephrosis: Overdiagnosed and undertreated. Nephrol Dial Transplant 22:2183-2193
11. Schwaderer P, Knuppel T, Konrad M, Mehls O, Scharer K, Schaefer F, Weber S (2008) Clinical course and NPHS2 analysis in patients with late steroid-resistant nephrotic syndrome. Pediatr Nephrol 23:251-256
12. Yi Z, Li Z, Wu XC, He QN, Dang XQ, He XJ (2006) Effect of fosinopril in children with steroid-resistant idiopathic nephrotic syndrome. Pediatr Nephrol 21:967-972
13. Bagga A, Mudigoudar BD, Hari P, Vasudev V (2004) Enalapril dosage in steroid-resistant nephrotic syndrome. Pediatr Nephrol 19:45-50
14. Cattran DC, Rao P (1998) Long-term outcome in children and adults with classic focal segmental glomerulosclerosis. Am J Kidney Dis 32:72-79
15. Abrantes MM, Cardosa LSB, Lima EM, Silva JMP, Diniz JS, Bambirra EA, Oliveira EA (2006) Clinical course of 110 children and adolescents with primary focal segmental glomerulosclerosis. Pediatr Nephrol 21:482-489
16. Abeyagunawardena AS, Sebire NJ, Risdon RA, Dillon MJ, Rees L, van't Hoff W, Kumarasiri PV, Trompeter RS (2007) Predictors of long-term outcome of children with idiopathic focal segmental glomerulosclerosis. Pediatr Nephrol 22:215-221
17. Hari P, Bagga A, Jindal N, Srivastava RN (2001) Treatment of focal glomerulosclerosis with pulse steroids and oral cyclophosphamide. Pediatr Nephrol 16:901-905
18. Bajpai A, Bagga A, Hari P, Dinda A, Srivastava RN (2003) Intravenous cyclophosphamide in steroid-resistant nephrotic syndrome. Pediatr Nephrol 18:351-356
19. Hari P, Bagga A, Mantan M (2004) Short term efficacy of intravenous dexamethasone and methylprednisolone therapy in steroid resistant nephrotic syndrome. Indian Pediatr 41:993-1000
20. Niaudet P (1994) Treatment of childhood steroid-resistant idiopathic nephrosis with a combination of cyclosporine and prednisone. French Society of Pediatric Nephrology. J Pediatr 125:981-986
21. Pena A, Bravo J, Melgosa M, Fernandez C, Meseguer C, Espinosa L, Alonso A, Picazo ML, Navarro M (2007) Steroid-resistant nephrotic syndrome: long-term evaluation after sequential therapy. Pediatr Nephrol 22:1875-1880
22. International Study of Kidney Disease in Children (1981) Primary nephrotic syndrome in children: Clinical significance of histopathologic variants of minimal change and of diffuse mesangial hypercellularity. A Report of the International Study of Kidney Disease in Children. Kidney Int 20:765-771
23. Hodson EM, Habashy D, Craig JC (2006) Interventions for idiopathic steroid-resistant nephrotic syndrome in children. Cochrane Database Syst Rev (2):CD003594
24. Singh A, Tejani C, Tejani A (1999) One-center experience with cyclosporine in refractory nephrotic syndrome in children. Pediatr Nephrol 13:26-32
25. Durkan A, Hodson EM, Willis NS, Craig JC (2005) Non-corticosteroid treatment for nephrotic syndrome in children. Cochrane Database Syst Rev (2):CD002290
26. Kleinknecht C, Broyer M, Gubler MC, Palcoux JB (1980) Irreversible renal failure after indomethacin in steroid resistant nephrosis. N Engl J Med 302:961
27. International study of Kidney Disease in Children (1974) Prospective, controlled trial of cyclophosphamide therapy in children with nephrotic syndrome. Report of the International study of Kidney Disease in Children. Lancet 2:423-427
28. Tarshish P, Tobin JN, Bernstein J, Edelmann CM Jr (1996) Cyclophosphamide does not benefit patients with focal segmental glomerulosclerosis. A report of the International Study of Kidney Disease in Children. Pediatr Nephrol 10:590-593
29. Martinelli R, Pereira LJ, Silva OM, Okumura AS, Rocha H (2004) Cyclophosphamide in the treatment of focal segmental glomerulosclerosis. Braz J Med Biol Res 37:1365-1372
30. Elhence R, Gulati S, Kher V, Gupta A, Sharma RK (1994) Intravenous pulse cyclophosphamide - a new regime for steroid-resistant minimal change nephrotic syndrome. Pediatr Nephrol 8:1-3
31. Gulati S, Kher V (2000) Intravenous pulse cyclophosphamide - a new regime for steroid-resistant focal segmental glomerulosclerosis. Indian Pediatr 37:141-148
32. Tune BM, Kirpekar R, Sibley RK, Reznik VM, Griswold WR, Mendoza SA (1995) Intravenous methylprednisolone and oral alkylating agent therapy of prednisone-resistant pediatric focal segmental glomerulosclerosis: A long-term follow-up. Clin Nephrol 43:84-88
33. Mantan M, Bagga A, Sriram CS, Hari P (2004) Efficacy of pulse cyclophosphamide (CP) vs IV steroids and oral CP for steroid resistant nephrotic syndrome. Pediatr Nephrol 19:C73
34. Plank C, Kalb V, Hinkes B, Hildebrandt F, Gefeller O, Rascher W; Arbeitsgemeinschaft für Pädiatrische Nephrologie (2008) Cyclosporin A is superior to cyclophosphamide in children with steroid-resistant nephrotic syndrome - a randomized controlled multicentre trial by the Arbeitsgemeinschaft für Pädiatrische Nephrologie. Pediatr Nephrol DOI 10.1007/s00467-008-0794-1
35. Cattran DC, Wang MM, Appel G, Matalon A, Briggs W (2004) Mycophenolate mofetil in the treatment of focal segmental glomerulosclerosis. Clin Nephrol 62:405-411
36. Bhimma R, Adhikari M, Asharam K, Connolly C (2006) Management of steroid-resistant focal segmental glomerulosclerosis in children using tacrolimus. Am J Nephrol 26:544-551
37. Bagga A, Sinha A, Moudgil A (2007) Rituximab in patients with the steroid-resistant nephrotic syndrome. N Engl J Med 356:2751-2752
38. Trachtman H, Gipson DS, Vento S, Thomson PD, Dike M (2007) Novel therapies for resistant FSGS: Preliminary results. Pediatr Nephrol 22:1629