Ivermectin resistance in Onchocerca volvulus: Toward a genetic basis

PLoS Neglected Tropical Diseases

Volumn 1, Issue 1, 2007, Pages

  Lustigman, Sara ^a   McCarter, James P ^b,c  

^a NEW YORK BLOOD CENTER   (United States)

^b Divergence Inc   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFILARIAL AGENT; BETA TUBULIN; DNA; FILARIAL VACCINE; INSECTICIDE; IVERMECTIN; VACCINE; ANTIPARASITIC AGENT; HELMINTH PROTEIN; TUBULIN;

ARTICLE; CLINICAL TRIAL; DISEASE TRANSMISSION; DRUG EFFICACY; ENDEMIC DISEASE; GENE FREQUENCY; GENE LOCUS; GENETIC ANALYSIS; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC SELECTION; GENOTYPE PHENOTYPE CORRELATION; HEALTH PROGRAM; HETEROZYGOSITY; HUMAN; INFECTION CONTROL; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PARASITE VECTOR; VECTOR CONTROL; AGED; ANIMAL; DRUG EFFECT; DRUG RESISTANCE; FEMALE; GENETICS; PARASITOLOGY; PHYSIOLOGY; REPRODUCTION; SKIN; SOUTH AMERICA;

AGED; ANIMALS; ANTIPARASITIC AGENTS; DRUG RESISTANCE; FEMALE; HELMINTH PROTEINS; HUMANS; IVERMECTIN; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; ONCHOCERCIASIS, OCULAR; POLYMORPHISM, GENETIC; REPRODUCTION; SELECTION, GENETIC; SKIN; SOUTH AMERICA; TUBULIN;

EID: 47749135637     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000076     Document Type: Article

References (33)

1. Richards FO Jr, Boatin B, Sauerbrey M, Seketeli A (2001) Control of onchocerciasis today: status and challenges. Trends Parasitol 17: 558-563.
2. African Programme for Onchocerciasis Control (2005) Final communiqué of the 11th session of the Joint Action Forum (JAF) of APOC, Paris, France, 6-9 December 2005. Available: http://www.apoc.bf/en/ download.htm. Accessed 3 August 2007.
3. Peters DH, Phillips T (2004) Mectizan Donation Program: Evaluation of a public private partnership. Trop Med Int Health 9: A4-A15.
4. Ejere H, Schwartz E, Wormald R (2001) Ivermectin for onchocercal eye disease (river blindness). Cochrane Database Syst Rev; CD002219.
5. Tielsch JM, Beeche A (2004) Impact of ivermectin on illness and disability associated with onchocerciasis. Trop Med Int Health 9: A45-A56.
6. Boussinesq M, Prod'hon J, Chippaux JP (1997) Onchocerca volvulus: Striking decrease in transmission in the Vina valley (Cameroon) after eight annual large scale ivermectin treatments. Trans R Soc Trop Med Hyg 91: 82-86.
7. Collins RC, Gonzales-Peralta C, Castro J, Zea-Flores G, Cupp MS, et al. (1992) Ivermectin: Reduction in prevalence and infection intensity of Onchocerca volvulus following biannual treatments in five Guatemalan communities. Am J Trop Med Hyg 47: 156-169.
8. Molyneux DH (1995) Onchocerciasis control in West Africa: Current status and future of the Onchocerciasis Control Programme. Parasitol Today 11: 399-402.
9. Boatin BA, Richards FO Jr (2006) Control of onchocerciasis. Adv Parasitol 61: 349-394.
10. Basáñez MG, Pion SD, Churcher TS, Breitling LP, Little MP, et al. (2006) River blindness: A success story under threat? PLoS Med 3: e371. doi:10.1371/journal.pmed.0030371
11. Remme JHF (1995) The African Programme for Onchocerciasis Control: Preparing to launch. Parasitol Today 11: 403-406.
12. Winnen M, Plaisier AP, Alley ES, Nagelkerke NJ, van Oortmarssen G, et al. (2002) Can ivermectin mass treatments eliminate onchocerciasis in Africa? Bull World Health Organ 80: 384-391.
13. Coles GC (2006) Drug resistance and drug tolerance in parasites. Trends Parasitol 22: 348; author reply 349.
14. Coles GC, Jackson F, Pomroy WE, Prichard RK, von Samson-Himmelstjerna G, et al. (2006) The detection of anthelmintic resistance in nematodes of veterinary importance. Vet Parasitol 136: 167-185.
15. Awadzi K, Attah SK, Addy ET, Opoku NO, Quartey BT, et al. (2004) Thirty-month follow-up of sub-optimal responders to multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana. Ann Trop Med Parasitol 98: 359-370.
16. Awadzi K, Boakye DA, Edwards G, Opoku NO, Attah SK, et al. (2001) An investigation of persistent microfilaridermias despite multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana. Ann Trop Med Parasitol 98: 231-249.
17. Osei-Atweneboana MY, Eng JK, Boakye DA, Gyapong JO, Prichard RK (2007) Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: A two-phase epidemiological study. Lancet 369: 2021-2029.
18. Kohler P (2001) The biochemical basis of anthelmintic action and resistance. Int J Parasitol 31: 336-345.
19. Huang YJ, Prichard RK (1999) Identification and stage-specific expression of two putative P-glycoprotein coding genes in Onchocerca vovulus. Mol Biochem Parasitol 102: 273-281.
20. Ardelli BF, Guerriero SB, Prichard RK (2005) Genomic organization and effects of ivermectin selection on Onchocerca volvulus P-glycoprotein. Mol Biocbem Parasitol 143: 58-66.
21. Bourguinat C, Pion SD, Kamgno J, Gardon J, Gardon-Wendel N, et al. (2006) Genetic polymorphisin of the beta-tubulin gene of Onchocerca volvulus in ivermectin naive patients from Cameroon, and its relationship with fertility of the worms. Parasitology 132: 1-8.
22. Eng JK, Prichard RK (2005) A comparison of genetic polymorphism in populations of Onchocerca volvulus from untreated- and ivermectin-treated patients. Mol Biochem Parasitol 142: 193-202.
23. Ardelli BF, Prichard RK (2004) Identification of variant ABC-transporter genes among Onchocerca volvulus collected from ivermectin-treated and untreated patients in Ghana, West Africa. Ann Trop Med Parasitol 98: 371-384.
24. Ardelli BF, Guerriero SB, Prichard RK (2006) Ivermectin imposes selection pressure on P-glycoprotein from Onchocerca volvulus: Linkage disequilibrium and genotype diversity. Parasitology 132: 375-386.
25. Ardelli BF, Guerriero SB, Prichard RK (2006) Characterization of a half-size ATP-binding cassette transporter gene which may be a useful marker for ivermectin selection in Onchocerca volvulus. Mol Biochem Parasitol 145: 94-100.
26. Eng JK, Blackhall WJ, Osei-Atweneboana MY, Bourguinat C, Galazzo D, et al. (2006) Ivermectin selection on beta-tubulin: Evidence in Onchocerca volvulus and Haemonchus contortus. Mol Biochem Parasitol 150: 229-235.
27. Bourguinat C, Pion SDS, Kamgno J, Gardon J, Duke BOL, et al. (2007) Genetic selection of low fertile Onchocerca volvulus by ivermectin treatment. PLoS Negl Trop Dis 1: e72. doi:10.1371/journal.pntd.0000072
28. Njue AI, Prichard RK (2004) Genetic variability of glutamate-gated chloride channel genes in ivermectin-susceptible and -resistant strains of Cooperia oncophora. Parasitology 129: 741-751.
29. Behm CA, Bendig MM, McCarter JP, Sluder AE (2005) RNAi-based discovery and validation of new drug targets in filarial nematodes. Trends Parasitol 21: 97-100.
30. Nwaka S, Hudson A (2006) Innovative lead discovery strategies for tropical diseases. Nat Rev Drug Discov 5: 941-955.
31. Cook JA, Steel C, Ottesen EA (2001) Towards a vaccine for onchocerciasis. Trends Parasitol 17: 555-558.
32. Hotez PJ, Ferris NIT (2006) The antipoverty vaccines. Vaccine 24: 5787-5799.
33. Hotez PJ (2007) Control of onchocerciasis - The next generation. Lancet 369: 1979-1980.