Physiologically based pharmacokinetic model development and simulations for ethylene dichloride (1,2-dichloroethane) in rats

Regulatory Toxicology and Pharmacology

Volumn 51, Issue 3, 2008, Pages 311-323

  Sweeney, Lisa M ^a   Saghir, Shakil A ^b   Gargas, Michael L ^a  

^a The Sapphire Group   (United States)

^b DOW CHEMICAL COMPANY   (United States)

Author keywords

Ethylene dichloride; Extrahepatic metabolism; PBPK model

Indexed keywords

1,2 DICHLOROETHANE; CYTOCHROME P450; GLUTATHIONE TRANSFERASE;

AIR POLLUTION; ANIMAL EXPERIMENT; ARTICLE; COMPUTER MODEL; COMPUTER SIMULATION; CONCENTRATION RESPONSE; DRUG CONJUGATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT STRAIN; RISK ASSESSMENT; STRAIN DIFFERENCE; TOXICITY TESTING; TOXICOKINETICS;

AIR POLLUTANTS; ANIMALS; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; ETHYLENE DICHLORIDES; FEMALE; GLUTATHIONE TRANSFERASE; INHALATION EXPOSURE; INJECTIONS, INTRAVENOUS; MALE; MODELS, BIOLOGICAL; RATS; RATS, INBRED STRAINS;

RATTUS;

EID: 47749126911     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2008.05.002     Document Type: Article

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