Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein s and factor V

Journal of Biological Chemistry

Volumn 283, Issue 24, 2008, Pages 16355-16362

  Gale, Andrew J ^a   Cramer, Thomas J ^a   Rozenshteyn, Diana ^a   Cruz, Jason R ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DISSOCIATION;

ACTIVATED PROTEINS; CLEAVAGE RATES; CLEAVAGE SITES; COFACTORS; DISULFIDE BONDS; FACTOR VIIIA; SERINE PROTEASES; STABLE ACTIVITIES; SUBUNIT DISSOCIATIONS;

GLYCOPROTEINS;

ACTIVATED PROTEIN C; ARGININE; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 8A; PROTEIN S; PROTEIN SUBUNIT; RECOMBINANT BLOOD CLOTTING FACTOR 8; DISULFIDE; PROTEIN C; THROMBIN;

ARTICLE; CONTROLLED STUDY; GENE INACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN FOLDING; PROTEIN FUNCTION; BIOCHEMISTRY; BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMISTRY; GENETICS; KINETICS; METABOLISM; METHODOLOGY; MUTATION; PROTEIN BINDING; TIME;

ARGININE; BIOCHEMISTRY; DISULFIDES; FACTOR V; FACTOR VIIIA; HUMANS; KINETICS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MUTATION; PROTEIN BINDING; PROTEIN C; PROTEIN S; THROMBIN; TIME FACTORS;

EID: 47749119205     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M708985200     Document Type: Article

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