Synthesis and evaluation of heteroaryl-ketone derivatives as a novel class of VEGFR-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 15, 2008, Pages 4344-4347

  Piatnitski Chekler, Eugene L ^a   Katoch Rouse, Reeti ^a   Kiselyov, Alexander S ^a   Sherman, Dan ^a   Ouyang, Xiaohu ^a   Kim, Ki ^a   Wang, Ying ^a   Hadari, Yaron R ^a   Doody, Jacqueline F ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Angiogenesis; Kinase inhibitor; Vascular endothelial growth factor

Indexed keywords

AMINE; KETONE DERIVATIVE; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE; VANDETANIB; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ASSAY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EMBRYO; ENZYME ASSAY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN;

ADMINISTRATION, ORAL; ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; INHIBITORY CONCENTRATION 50; KETONES; MICE; MOLECULAR STRUCTURE; PIPERIDINES; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

MUS;

EID: 47749111655     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.06.083     Document Type: Article

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