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Volumn 24, Issue 7, 2008, Pages 392-398

Effects of metformin and ethinyl estradiol-cyproterone acetate on clinical, endocrine and metabolic factors in women with polycystic ovary syndrome

Author keywords

Hyperandrogenism; Hyperinsulinemia; Metformin; Oral contraceptive pill; Polycystic ovary syndrome

Indexed keywords

DIANE; FOLLITROPIN; LUTEINIZING HORMONE; METFORMIN; TESTOSTERONE;

EID: 47749106070     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.1080/09513590802217027     Document Type: Article
Times cited : (37)

References (33)
  • 1
    • 0031773509 scopus 로고    scopus 로고
    • Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study
    • Knochenhauer ES, Key TJ, Kahsar-Miller M, Waggoner W, Boots LR, Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab 1998;83:3078-3082.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3078-3082
    • Knochenhauer, E.S.1    Key, T.J.2    Kahsar-Miller, M.3    Waggoner, W.4    Boots, L.R.5    Azziz, R.6
  • 2
    • 34347272619 scopus 로고    scopus 로고
    • Prevalence, definition and clinical manifestations of polycystic ovary syndrome
    • Diamanti-Kandarakis E, Christakou C. Prevalence, definition and clinical manifestations of polycystic ovary syndrome. Endocrinol Nutr 2006; 53(Suppl 1):25-33.
    • (2006) Endocrinol Nutr , vol.53 , Issue.SUPPL. 1 , pp. 25-33
    • Diamanti-Kandarakis, E.1    Christakou, C.2
  • 4
    • 0035127474 scopus 로고    scopus 로고
    • Current concepts in the polycystic ovary syndrome
    • Dunaif A, Thomas A. Current concepts in the polycystic ovary syndrome. Annu Rev Med 2001;52:401-419.
    • (2001) Annu Rev Med , vol.52 , pp. 401-419
    • Dunaif, A.1    Thomas, A.2
  • 6
    • 0038687067 scopus 로고    scopus 로고
    • Insulin resistance: What is its role in PCOS?
    • Moghetti P. Insulin resistance: what is its role in PCOS? Curr Opin Endocrinol Diabetes 2002;9:444-450.
    • (2002) Curr Opin Endocrinol Diabetes , vol.9 , pp. 444-450
    • Moghetti, P.1
  • 8
    • 1842678279 scopus 로고    scopus 로고
    • Should insulin-sensitizing drugs be used in the treatment of polycystic ovary syndrome?
    • Cheang KI, Nestler JE. Should insulin-sensitizing drugs be used in the treatment of polycystic ovary syndrome? Reprod Biomed Online 2004;8:440-447.
    • (2004) Reprod Biomed Online , vol.8 , pp. 440-447
    • Cheang, K.I.1    Nestler, J.E.2
  • 9
    • 0033840878 scopus 로고    scopus 로고
    • Insulin-lowering medications in polycystic ovary syndrome
    • Taylor AE. Insulin-lowering medications in polycystic ovary syndrome. Obstet Gynecol Clin North Am 2000;27:583-595.
    • (2000) Obstet Gynecol Clin North Am , vol.27 , pp. 583-595
    • Taylor, A.E.1
  • 10
    • 34447096147 scopus 로고    scopus 로고
    • Metformin versus oral contraceptive pill in polycystic ovary syndrome: A Cochrane review
    • Costello MF, Shrestha B, Eden J, Johnson NP, Sjoblom P. Metformin versus oral contraceptive pill in polycystic ovary syndrome: a Cochrane review. Hum Reprod 2007;22:1200-1209.
    • (2007) Hum Reprod , vol.22 , pp. 1200-1209
    • Costello, M.F.1    Shrestha, B.2    Eden, J.3    Johnson, N.P.4    Sjoblom, P.5
  • 12
    • 0034111902 scopus 로고    scopus 로고
    • Metformin therapy decreases hyperandrogenism and hyper-insulinemia in women with polycystic ovary syndrome
    • Kolodziejczyk B, Duleba AJ, Spaczynski RZ, Pawelczyk L. Metformin therapy decreases hyperandrogenism and hyper-insulinemia in women with polycystic ovary syndrome. Fertil Steril 2000;73:1149-1154.
    • (2000) Fertil Steril , vol.73 , pp. 1149-1154
    • Kolodziejczyk, B.1    Duleba, A.J.2    Spaczynski, R.Z.3    Pawelczyk, L.4
  • 14
    • 0142185995 scopus 로고    scopus 로고
    • Insulin-lowering agents in the management of polycystic ovary syndrome
    • De Leo V, La Marca A, Petraglia F. Insulin-lowering agents in the management of polycystic ovary syndrome. Endocr Rev 2003;24:633-667.
    • (2003) Endocr Rev , vol.24 , pp. 633-667
    • De Leo, V.1    La Marca, A.2    Petraglia, F.3
  • 15
    • 33144468542 scopus 로고    scopus 로고
    • The effects of rosiglitazone and metformin on insulin resistance and serum androgen levels in obese and lean patients with polycystic ovary syndrome
    • Yilmaz M, Biri A, Karakoc A, Tortuner F, Bingol B, Cakir N, Tiras B, Avvaz G, Arslan M. The effects of rosiglitazone and metformin on insulin resistance and serum androgen levels in obese and lean patients with polycystic ovary syndrome. J Endocrinol Invest 2005;28:1003-1008.
    • (2005) J Endocrinol Invest , vol.28 , pp. 1003-1008
    • Yilmaz, M.1    Biri, A.2    Karakoc, A.3    Tortuner, F.4    Bingol, B.5    Cakir, N.6    Tiras, B.7    Avvaz, G.8    Arslan, M.9
  • 16
    • 0347986534 scopus 로고    scopus 로고
    • Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome
    • Genazzani AD, Battaglia C, Malavasi B, Strucchi C, Torolani F, Gamba O. Metformin administration modulates and restores luteinizing hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome. Fertil Steril 2004;81:114-119.
    • (2004) Fertil Steril , vol.81 , pp. 114-119
    • Genazzani, A.D.1    Battaglia, C.2    Malavasi, B.3    Strucchi, C.4    Torolani, F.5    Gamba, O.6
  • 17
    • 34147119062 scopus 로고    scopus 로고
    • Metformin administration is more effective when non-obese patients with polycystic ovary syndrome show both hyperandrogenism and hyperinsulinemia
    • Genazzani AD, Lanzoni C, Ricchieri F, Baraldi E, Casarosa E, Jasonni VM. Metformin administration is more effective when non-obese patients with polycystic ovary syndrome show both hyperandrogenism and hyperinsulinemia. Gynecol Endocrinol 2007;23:146-152.
    • (2007) Gynecol Endocrinol , vol.23 , pp. 146-152
    • Genazzani, A.D.1    Lanzoni, C.2    Ricchieri, F.3    Baraldi, E.4    Casarosa, E.5    Jasonni, V.M.6
  • 18
    • 35848938638 scopus 로고    scopus 로고
    • Insulin-sensitizing drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome
    • CD005552
    • Costello M, Shrestha B, Eden J, Sjoblom P, Johnson N. Insulin-sensitizing drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome. Cochrane Database Syst Rev 2007;24:CD005552.
    • (2007) Cochrane Database Syst Rev , vol.24
    • Costello, M.1    Shrestha, B.2    Eden, J.3    Sjoblom, P.4    Johnson, N.5
  • 19
    • 0346186090 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to PCOS
    • The Rotterdam ESHRE/ASRM-sponsored PCOS consensus working group
    • The Rotterdam ESHRE/ASRM-sponsored PCOS consensus working group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to PCOS. Hum Reprod 2004;19:41-47.
    • (2004) Hum Reprod , vol.19 , pp. 41-47
  • 20
    • 0003366940 scopus 로고    scopus 로고
    • Terminology and differential diagnosis of genital tract bleeding in women
    • Snyder PJ, Utiger RD, editors, Wellesley (MA):UpToDate, Inc
    • Goodman A. Terminology and differential diagnosis of genital tract bleeding in women. In: Snyder PJ, Utiger RD, editors. Up to date in endocrinology and diabetes. Wellesley (MA):UpToDate, Inc., 1999.
    • (1999) Up to date in endocrinology and diabetes
    • Goodman, A.1
  • 22
    • 0031787388 scopus 로고    scopus 로고
    • Fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome
    • Legro RS, Finegood D, Dunaif A. Fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1998;83:2694-2698.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2694-2698
    • Legro, R.S.1    Finegood, D.2    Dunaif, A.3
  • 23
    • 34447127552 scopus 로고    scopus 로고
    • Comparison of ethinyl-estradiol plus cyproterone acetate versus metformin effects on classic metabolic cardiovascular risk factors in women with the polycystic ovary syndrome
    • Luque-Ramirez M, Alvarez-Blasco F, Botella-Carretero JI, Martinez-Bermejo E, Lasuncion MA, Escobar-Morreale HF. Comparison of ethinyl-estradiol plus cyproterone acetate versus metformin effects on classic metabolic cardiovascular risk factors in women with the polycystic ovary syndrome. J Clin Endocrinol Metab 2007;92:2453-2461.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2453-2461
    • Luque-Ramirez, M.1    Alvarez-Blasco, F.2    Botella-Carretero, J.I.3    Martinez-Bermejo, E.4    Lasuncion, M.A.5    Escobar-Morreale, H.F.6
  • 24
    • 0033305292 scopus 로고    scopus 로고
    • A prospective randomized trail comparing low dose flutamide, finasteride, ketoconazole, and cyproterone acetate-estrogen regimens in the treatment of hirsutism
    • Venturoli S, Marescalchi O, Colombo FM, Macrelli S, Ravaioli B, Bagnoli A, Paradisi R, Flamigni C. A prospective randomized trail comparing low dose flutamide, finasteride, ketoconazole, and cyproterone acetate-estrogen regimens in the treatment of hirsutism. J Clin Endocrinol Metab 1999;84:1304-1310.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1304-1310
    • Venturoli, S.1    Marescalchi, O.2    Colombo, F.M.3    Macrelli, S.4    Ravaioli, B.5    Bagnoli, A.6    Paradisi, R.7    Flamigni, C.8
  • 26
    • 0036063322 scopus 로고    scopus 로고
    • Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovary syndrome: A randomized controlled study
    • Elter K, Imir G, Durmusoglu F. Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovary syndrome: a randomized controlled study. Hum Reprod 2002;17:1729-1737.
    • (2002) Hum Reprod , vol.17 , pp. 1729-1737
    • Elter, K.1    Imir, G.2    Durmusoglu, F.3
  • 27
    • 0036165847 scopus 로고    scopus 로고
    • Insulin sensitivity in non-obese women with polycystic ovary syndrome during treatment with oral contraceptives containing low-androgenic progestin
    • Cibula D, Sindelka G, Hill M, Fanta M, Skrha J, Zivny J. Insulin sensitivity in non-obese women with polycystic ovary syndrome during treatment with oral contraceptives containing low-androgenic progestin. Hum Reprod 2002;17:76-82.
    • (2002) Hum Reprod , vol.17 , pp. 76-82
    • Cibula, D.1    Sindelka, G.2    Hill, M.3    Fanta, M.4    Skrha, J.5    Zivny, J.6
  • 28
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and polycystic ovary syndrome: Mechanism and implication for pathogenesis
    • Dunaif A. Insulin resistance and polycystic ovary syndrome: mechanism and implication for pathogenesis. Endocr Rev 1997;18:774-800.
    • (1997) Endocr Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 30
    • 0028315971 scopus 로고
    • Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia and systolic blood pressure while facilitating normal menses and pregnancy
    • Velazquez EM, Mendoza S, Hamer T, Sosa F, Glueck CJ. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia and systolic blood pressure while facilitating normal menses and pregnancy. Metab Clin Exp 1994;43:647-654.
    • (1994) Metab Clin Exp , vol.43 , pp. 647-654
    • Velazquez, E.M.1    Mendoza, S.2    Hamer, T.3    Sosa, F.4    Glueck, C.J.5
  • 31
    • 0037299936 scopus 로고    scopus 로고
    • Effects of metformin therapy on hyperandrogenism in women with polycystic ovary syndrome
    • Kazerooni T, Dehghan-Kooshkghazi M. Effects of metformin therapy on hyperandrogenism in women with polycystic ovary syndrome. Gynecol Endocrinol 2003;17:51-56.
    • (2003) Gynecol Endocrinol , vol.17 , pp. 51-56
    • Kazerooni, T.1    Dehghan-Kooshkghazi, M.2
  • 33
    • 34249912568 scopus 로고    scopus 로고
    • Metformin improves menstrual patterns, endocrine and metabolic profile in obese hyperinsulinemic women with a polycystic ovary syndrome
    • Krstevska B, Dimitrovski Ch, Pemovska G, Misevska S, Dimova Z, Simeonova S, Ahmeti I. Metformin improves menstrual patterns, endocrine and metabolic profile in obese hyperinsulinemic women with a polycystic ovary syndrome. Prilozi 2006;27:57-66.
    • (2006) Prilozi , vol.27 , pp. 57-66
    • Krstevska, B.1    Dimitrovski, C.2    Pemovska, G.3    Misevska, S.4    Dimova, Z.5    Simeonova, S.6    Ahmeti, I.7


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