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Volumn 4, Issue 2, 2008, Pages 73-79

Pre-dementia diagnosis of Alzheimer's disease: Translating clinicobiologic research into practice

Author keywords

Alzheimer's disease; Cerebrospinal fluid; Magnetic resonance imaging; Mild cognitive impairment; Neuropsychology; Positron emission tomography

Indexed keywords

AMYLOID; APOLIPOPROTEIN E4; BIOLOGICAL MARKER;

EID: 47749100141     PISSN: 15734005     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340008784529296     Document Type: Review
Times cited : (1)

References (61)
  • 1
    • 35848962080 scopus 로고    scopus 로고
    • Disease-modifying therapies for Alzheimer disease: Challenges to early intervention
    • Cummings JL, Doody R,Clark C. Disease-modifying therapies for Alzheimer disease: challenges to early intervention. Neurology 2007; 69: 1622-1634.
    • (2007) Neurology , vol.69 , pp. 1622-1634
    • Cummings, J.L.1    Doody, R.2    Clark, C.3
  • 2
    • 0242363668 scopus 로고    scopus 로고
    • Looking backward to move forward: Early detection of neurodegenerative disorders
    • DeKosky ST,Marek K. Looking backward to move forward: early detection of neurodegenerative disorders. Science 2003; 302: 830-834.
    • (2003) Science , vol.302 , pp. 830-834
    • DeKosky, S.T.1    Marek, K.2
  • 3
    • 33646168245 scopus 로고    scopus 로고
    • Hippocampal synaptic loss in ea rly Alzheimer's disease and mild cognitive impairment
    • Scheff SW, Price DA, Schmitt FA,Mufson EJ. Hippocampal synaptic loss in ea rly Alzheimer's disease and mild cognitive impairment. Neurobiol Aging 2005.
    • (2005) Neurobiol Aging
    • Scheff, S.W.1    Price, D.A.2    Schmitt, F.A.3    Mufson, E.J.4
  • 5
    • 0034849725 scopus 로고    scopus 로고
    • Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease
    • Price JL, Ko AI, Wade MJ, Tsou SK, McKeel DW,Morris JC. Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease. Arch Neurol 2001; 58: 1395-1402.
    • (2001) Arch Neurol , vol.58 , pp. 1395-1402
    • Price, J.L.1    Ko, A.I.2    Wade, M.J.3    Tsou, S.K.4    McKeel, D.W.5    Morris, J.C.6
  • 6
    • 34447322271 scopus 로고    scopus 로고
    • Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria
    • Dubois B, Feldman HH, Jacova C, et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007; 6: 734-746.
    • (2007) Lancet Neurol , vol.6 , pp. 734-746
    • Dubois, B.1    Feldman, H.H.2    Jacova, C.3
  • 8
    • 4544350756 scopus 로고    scopus 로고
    • Mild cognitive impairment-beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment
    • Winblad B, Palmer K, Kivipelto M, et al. Mild cognitive impairment-beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 2004; 256: 240-246.
    • (2004) J Intern Med , vol.256 , pp. 240-246
    • Winblad, B.1    Palmer, K.2    Kivipelto, M.3
  • 9
    • 4544335597 scopus 로고    scopus 로고
    • Mild cognitive impairment as a diagnostic entity
    • Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256: 183-194.
    • (2004) J Intern Med , vol.256 , pp. 183-194
    • Petersen, R.C.1
  • 10
    • 33646392455 scopus 로고    scopus 로고
    • Neuropathologic features of amnestic mild cognitive impairment
    • Petersen RC, Parisi JE, Dickson DW, et al. Neuropathologic features of amnestic mild cognitive impairment. Arch Neurol 2006; 63: 665-672.
    • (2006) Arch Neurol , vol.63 , pp. 665-672
    • Petersen, R.C.1    Parisi, J.E.2    Dickson, D.W.3
  • 11
    • 0036224457 scopus 로고    scopus 로고
    • Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: Findings from the Nun Study
    • Riley KP, Snowdon DA,Markesbery WR. Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Ann Neurol 2002; 51: 567-577.
    • (2002) Ann Neurol , vol.51 , pp. 567-577
    • Riley, K.P.1    Snowdon, D.A.2    Markesbery, W.R.3
  • 12
    • 14644416500 scopus 로고    scopus 로고
    • Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
    • Bennett DA, Schneider JA, Bienias JL, Evans DA, Wilson RS. Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions. Neurology 2005; 64: 834-841.
    • (2005) Neurology , vol.64 , pp. 834-841
    • Bennett, D.A.1    Schneider, J.A.2    Bienias, J.L.3    Evans, D.A.4    Wilson, R.S.5
  • 13
    • 36849016403 scopus 로고    scopus 로고
    • Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment
    • Dickerson BC, Sperling RA, Hyman BT, Albert MS, Blacker D. Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment. Arch Gen Psychiatry 2007; 64: 1443-1450.
    • (2007) Arch Gen Psychiatry , vol.64 , pp. 1443-1450
    • Dickerson, B.C.1    Sperling, R.A.2    Hyman, B.T.3    Albert, M.S.4    Blacker, D.5
  • 14
    • 33747054765 scopus 로고    scopus 로고
    • Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI
    • Storandt M, Grant EA, Miller JP,Morris JC. Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI. Neurology 2006; 67: 467-473.
    • (2006) Neurology , vol.67 , pp. 467-473
    • Storandt, M.1    Grant, E.A.2    Miller, J.P.3    Morris, J.C.4
  • 15
    • 34848906841 scopus 로고    scopus 로고
    • Focal cortical presentations of Alzheimer's disease
    • Alladi S, Xuereb J, Bak T, et al. Focal cortical presentations of Alzheimer's disease. Brain 2007; 130: 2636-2645.
    • (2007) Brain , vol.130 , pp. 2636-2645
    • Alladi, S.1    Xuereb, J.2    Bak, T.3
  • 17
    • 0032850581 scopus 로고    scopus 로고
    • Clinical and pathological evidence for a frontal variant of Alzheimer disease
    • Johnson JK, Head E, Kim R, Starr A, Cotman CW.Clinical and pathological evidence for a frontal variant of Alzheimer disease. Arch Neurol 1999; 56: 1233-1239.
    • (1999) Arch Neurol , vol.56 , pp. 1233-1239
    • Johnson, J.K.1    Head, E.2    Kim, R.3    Starr, A.4    Cotman, C.W.5
  • 18
    • 34247196532 scopus 로고    scopus 로고
    • 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration
    • Rabinovici GD, Furst AJ, O'Neil JP, et al. 11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration. Neurology 2007; 68: 1205-1212.
    • (2007) Neurology , vol.68 , pp. 1205-1212
    • Rabinovici, G.D.1    Furst, A.J.2    O'Neil, J.P.3
  • 19
    • 16344382740 scopus 로고    scopus 로고
    • Neuroimaging Biomarkers for Clinical Trials of Disease-Modifying Therapies in Alzheimer's Disease
    • Dickerson BC, Sperling RA. Neuroimaging Biomarkers for Clinical Trials of Disease-Modifying Therapies in Alzheimer's Disease. NeuroRx 2005; 2: 348-360.
    • (2005) NeuroRx , vol.2 , pp. 348-360
    • Dickerson, B.C.1    Sperling, R.A.2
  • 20
    • 33144484244 scopus 로고    scopus 로고
    • Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuro-imaging Initiative (ADNI)
    • Mueller SG, Weiner MW, Thal LJ, et al. Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuro-imaging Initiative (ADNI). Alzheimer's and Dementia 2005; 1: 55-66.
    • (2005) Alzheimer's and Dementia , vol.1 , pp. 55-66
    • Mueller, S.G.1    Weiner, M.W.2    Thal, L.J.3
  • 21
    • 0034127931 scopus 로고    scopus 로고
    • Killiany RJ, Gomez-Isla T, Moss M, et al. Use of structural magnetic resonance imaging to predict who will get alzheimer's disease. Ann Neurol 2000; 47: 430-439.
    • Killiany RJ, Gomez-Isla T, Moss M, et al. Use of structural magnetic resonance imaging to predict who will get alzheimer's disease. Ann Neurol 2000; 47: 430-439.
  • 22
    • 0344889207 scopus 로고    scopus 로고
    • Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
    • Jack CR, Jr., Petersen RC, Xu YC, et al. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment. Neurology 1999; 52: 1397-1403.
    • (1999) Neurology , vol.52 , pp. 1397-1403
    • Jack Jr., C.R.1    Petersen, R.C.2    Xu, Y.C.3
  • 23
    • 0027194145 scopus 로고
    • The radiologic prediction of Alzheimer disease: The atrophic hippocampal formation
    • de Leon MJ, Golomb J, George AE, et al. The radiologic prediction of Alzheimer disease: the atrophic hippocampal formation. AJNR Am J Neuroradiol 1993; 14: 897-906.
    • (1993) AJNR Am J Neuroradiol , vol.14 , pp. 897-906
    • de Leon, M.J.1    Golomb, J.2    George, A.E.3
  • 24
    • 0035173606 scopus 로고    scopus 로고
    • MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease
    • Dickerson BC, Goncharova I, Sullivan MP, et al. MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease. Neurobiol Aging 2001; 22: 747-754.
    • (2001) Neurobiol Aging , vol.22 , pp. 747-754
    • Dickerson, B.C.1    Goncharova, I.2    Sullivan, M.P.3
  • 25
    • 0034099077 scopus 로고    scopus 로고
    • Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: Power calculations and estimates of sample size to detect treatment effects
    • Fox NC, Cousens S, Scahill R, Harvey RJ, Rossor MN. Using serial registered brain magnetic resonance imaging to measure disease progression in Alzheimer disease: power calculations and estimates of sample size to detect treatment effects. Arch Neurol 2000; 57: 339-344.
    • (2000) Arch Neurol , vol.57 , pp. 339-344
    • Fox, N.C.1    Cousens, S.2    Scahill, R.3    Harvey, R.J.4    Rossor, M.N.5
  • 26
    • 33749442924 scopus 로고    scopus 로고
    • Combining short interval MRI in Alzheimer's disease: Implications for therapeutic trials
    • Schott JM, Frost C, Whitwell JL, et al. Combining short interval MRI in Alzheimer's disease: Implications for therapeutic trials. J Neurol 2006; 253: 1147-1153.
    • (2006) J Neurol , vol.253 , pp. 1147-1153
    • Schott, J.M.1    Frost, C.2    Whitwell, J.L.3
  • 27
    • 47749111163 scopus 로고    scopus 로고
    • Atrophy rates accelerate in amnestic mild cognitive impairment
    • Epub ahead of print
    • Jack CR, Jr., Weigand SD, Shiung MM, et al. Atrophy rates accelerate in amnestic mild cognitive impairment. Neurology 2007; (Epub ahead of print).
    • (2007) Neurology
    • Jack Jr., C.R.1    Weigand, S.D.2    Shiung, M.M.3
  • 28
    • 0037308009 scopus 로고    scopus 로고
    • Assessing the onset of structural change in familial Alzheimer's disease
    • Schott JM, Fox NC, Frost C, et al. Assessing the onset of structural change in familial Alzheimer's disease. Arm Neurol 2003; 53: 181-188.
    • (2003) Arm Neurol , vol.53 , pp. 181-188
    • Schott, J.M.1    Fox, N.C.2    Frost, C.3
  • 29
    • 39049173162 scopus 로고    scopus 로고
    • Neuropathological basis of magnetic resonance images in aging and dementia
    • Jagust WJ, Zheng L, Harvey DJ, et al. Neuropathological basis of magnetic resonance images in aging and dementia. Ann Neurol 2007; 63(1): 72-80.
    • (2007) Ann Neurol , vol.63 , Issue.1 , pp. 72-80
    • Jagust, W.J.1    Zheng, L.2    Harvey, D.J.3
  • 30
    • 47749117081 scopus 로고    scopus 로고
    • Differential effects of aging and Alzheimer's disease on medial temporal lobe cortical thickness and surface area
    • Epub ahead of print
    • Dickerson BC, Feczko E, Augustinack JC, et al. Differential effects of aging and Alzheimer's disease on medial temporal lobe cortical thickness and surface area. Neurobiol Aging 2007; (Epub ahead of print).
    • (2007) Neurobiol Aging
    • Dickerson, B.C.1    Feczko, E.2    Augustinack, J.C.3
  • 31
    • 0037007045 scopus 로고    scopus 로고
    • Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI
    • Scahill RI, Schott JM, Stevens JM, Rossor MN, Fox NC. Mapping the evolution of regional atrophy in Alzheimer's disease: unbiased analysis of fluid-registered serial MRI. Proc Natl Acad Sci USA 2002; 99: 4703-4707.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 4703-4707
    • Scahill, R.I.1    Schott, J.M.2    Stevens, J.M.3    Rossor, M.N.4    Fox, N.C.5
  • 32
    • 39749145604 scopus 로고    scopus 로고
    • MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment
    • Whitwell JL, Shiung MM, Przybelski SA, et al. MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment. Neurology 2007.
    • (2007) Neurology
    • Whitwell, J.L.1    Shiung, M.M.2    Przybelski, S.A.3
  • 33
    • 36048960470 scopus 로고    scopus 로고
    • Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths
    • Dickerson BC, Fenstermacher E, Salat DH, et al. Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths. Neuroimage 2008; 39: 10-18.
    • (2008) Neuroimage , vol.39 , pp. 10-18
    • Dickerson, B.C.1    Fenstermacher, E.2    Salat, D.H.3
  • 34
    • 0037066123 scopus 로고    scopus 로고
    • Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia
    • Jack CR, Jr., Dickson DW, Parisi JE, et al. Antemortem MRI findings correlate with hippocampal neuropathology in typical aging and dementia. Neurology 2002; 58: 750-757.
    • (2002) Neurology , vol.58 , pp. 750-757
    • Jack Jr., C.R.1    Dickson, D.W.2    Parisi, J.E.3
  • 35
    • 0033994846 scopus 로고    scopus 로고
    • Hemispheric differences in hippocampal volume predict verbal and spatial memory performance in patients with Alzheimer's disease
    • de Toledo-Morrell L, Dickerson B, Sullivan MP, Spanovic C, Wilson R,Bennett DA. Hemispheric differences in hippocampal volume predict verbal and spatial memory performance in patients with Alzheimer's disease. Hippocampus 2000; 10: 136-142.
    • (2000) Hippocampus , vol.10 , pp. 136-142
    • de Toledo-Morrell, L.1    Dickerson, B.2    Sullivan, M.P.3    Spanovic, C.4    Wilson, R.5    Bennett, D.A.6
  • 36
    • 0037469189 scopus 로고    scopus 로고
    • MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD
    • Jack CR, Jr., Slomkowski M, Gracon S, et al. MRI as a biomarker of disease progression in a therapeutic trial of milameline for AD. Neurology 2003; 60: 253-260.
    • (2003) Neurology , vol.60 , pp. 253-260
    • Jack Jr., C.R.1    Slomkowski, M.2    Gracon, S.3
  • 37
    • 0023898284 scopus 로고
    • Longitudinal studies of regional cerebral metabolism in Alzheimer's disease
    • Jagust WJ, Friedland RP, Budinger TF, Koss E,Ober B. Longitudinal studies of regional cerebral metabolism in Alzheimer's disease. Neurology 1988; 38: 909-912.
    • (1988) Neurology , vol.38 , pp. 909-912
    • Jagust, W.J.1    Friedland, R.P.2    Budinger, T.F.3    Koss, E.4    Ober, B.5
  • 38
    • 0036743220 scopus 로고    scopus 로고
    • Discrimination between Alzheimer dementia and controls by automated analysis of multi-center FDG PET
    • Herholz K, Salmon E, Perani D, et al. Discrimination between Alzheimer dementia and controls by automated analysis of multi-center FDG PET. Neuroimage 2002; 17: 302-316.
    • (2002) Neuroimage , vol.17 , pp. 302-316
    • Herholz, K.1    Salmon, E.2    Perani, D.3
  • 39
    • 20144379890 scopus 로고    scopus 로고
    • FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment
    • Chetelat G, Eustache F, Viader F, et al. FDG-PET measurement is more accurate than neuropsychological assessments to predict global cognitive deterioration in patients with mild cognitive impairment. Neurocase 2005; 11: 14-25.
    • (2005) Neurocase , vol.11 , pp. 14-25
    • Chetelat, G.1    Eustache, F.2    Viader, F.3
  • 40
    • 20444423242 scopus 로고    scopus 로고
    • Reduced hippocampal metabolism in MCI and AD: Automated FDG-PET image analysis
    • Mosconi L, Tsui WH, De Santi S, et al. Reduced hippocampal metabolism in MCI and AD: automated FDG-PET image analysis. Neurology 2005; 64: 1860-1867.
    • (2005) Neurology , vol.64 , pp. 1860-1867
    • Mosconi, L.1    Tsui, W.H.2    De Santi, S.3
  • 41
    • 0030874251 scopus 로고    scopus 로고
    • Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
    • Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 1997; 42: 85-94.
    • (1997) Ann Neurol , vol.42 , pp. 85-94
    • Minoshima, S.1    Giordani, B.2    Berent, S.3    Frey, K.A.4    Foster, N.L.5    Kuhl, D.E.6
  • 42
    • 0031747565 scopus 로고    scopus 로고
    • Preclinical prediction of Alzheimer's disease using SPECT
    • Johnson KA, Jones K, Holman BL, et al. Preclinical prediction of Alzheimer's disease using SPECT. Neurology 1998; 50: 1563-1571.
    • (1998) Neurology , vol.50 , pp. 1563-1571
    • Johnson, K.A.1    Jones, K.2    Holman, B.L.3
  • 43
    • 0033615219 scopus 로고    scopus 로고
    • Mapping biochemistry to metabolism: FDG-PET and amyloid burden in Alzheimer's disease
    • Mega MS, Chu T, Mazziotta JC, et al. Mapping biochemistry to metabolism: FDG-PET and amyloid burden in Alzheimer's disease. Neuroreport 1999; 10: 2911-2917.
    • (1999) Neuroreport , vol.10 , pp. 2911-2917
    • Mega, M.S.1    Chu, T.2    Mazziotta, J.C.3
  • 44
    • 23944444806 scopus 로고    scopus 로고
    • Molecular, structural, and functional characterization of Alzheimer's disease: Evidence for a relationship between default activity, amyloid, and memory
    • Buckner RL, Snyder AZ, Shannon BJ, et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J Neurosci 2005; 25: 7709-7717.
    • (2005) J Neurosci , vol.25 , pp. 7709-7717
    • Buckner, R.L.1    Snyder, A.Z.2    Shannon, B.J.3
  • 45
    • 34548219060 scopus 로고    scopus 로고
    • What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia?
    • Jagust W, Reed B, Mungas D, Ellis W, Decarli C. What does fluorodeoxyglucose PET imaging add to a clinical diagnosis of dementia? Neurology 2007; 69: 871-877.
    • (2007) Neurology , vol.69 , pp. 871-877
    • Jagust, W.1    Reed, B.2    Mungas, D.3    Ellis, W.4    Decarli, C.5
  • 46
    • 0035853154 scopus 로고    scopus 로고
    • Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease
    • Reiman EM, Caselli RJ, Chen K, Alexander GE, Bandy D, Frost J. Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease. Proc Natl Acad Sci USA 2001; 98: 3334-3339.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3334-3339
    • Reiman, E.M.1    Caselli, R.J.2    Chen, K.3    Alexander, G.E.4    Bandy, D.5    Frost, J.6
  • 47
    • 0029970342 scopus 로고    scopus 로고
    • Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E
    • Reiman EM, Caselli RJ, Yun LS, et al. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 1996; 334: 752-758.
    • (1996) N Engl J Med , vol.334 , pp. 752-758
    • Reiman, E.M.1    Caselli, R.J.2    Yun, L.S.3
  • 48
    • 0347719366 scopus 로고    scopus 로고
    • Reiman EM, Chen K, Alexander GE, et al. Functional brain abnormalities in young adults at genetic risk for late-onset alzheimer's dementia. Proc Natl Acad Sci U S A 2004; 101: 284-289.
    • Reiman EM, Chen K, Alexander GE, et al. Functional brain abnormalities in young adults at genetic risk for late-onset alzheimer's dementia. Proc Natl Acad Sci U S A 2004; 101: 284-289.
  • 49
    • 10744232413 scopus 로고    scopus 로고
    • Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    • Klunk WE, Engler H, Nordberg A, et al. Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Ann Neurol 2004; 55: 306-319.
    • (2004) Ann Neurol , vol.55 , pp. 306-319
    • Klunk, W.E.1    Engler, H.2    Nordberg, A.3
  • 50
    • 33845707784 scopus 로고    scopus 로고
    • PET of brain amyloid and tau in mild cognitive impairment
    • Small GW, Kepe V, Ercoli LM, et al. PET of brain amyloid and tau in mild cognitive impairment. N Engl J Med 2006; 355: 2652-2663.
    • (2006) N Engl J Med , vol.355 , pp. 2652-2663
    • Small, G.W.1    Kepe, V.2    Ercoli, L.M.3
  • 51
    • 33747048954 scopus 로고    scopus 로고
    • 11C]CPIB in a nondemented population: Potential antecedent marker of Alzheimer disease
    • Mintun MA, Larossa GN, Sheline YI, et al. [11C]CPIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 2006; 67: 446-452.
    • (2006) Neurology , vol.67 , pp. 446-452
    • Mintun, M.A.1    Larossa, G.N.2    Sheline, Y.I.3
  • 52
    • 0014326852 scopus 로고
    • Observations on the brains of non-demented old people
    • Tomlinson BE, Blessed G, Roth M. Observations on the brains of non-demented old people. J Neurol Sci 1968; 7: 331-356.
    • (1968) J Neurol Sci , vol.7 , pp. 331-356
    • Tomlinson, B.E.1    Blessed, G.2    Roth, M.3
  • 53
    • 38049036228 scopus 로고    scopus 로고
    • Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
    • epub ahead of print
    • Brys M, Pirraglia E, Rich K, et al. Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment. Neurobiol Aging 2007; [epub ahead of print].
    • (2007) Neurobiol Aging
    • Brys, M.1    Pirraglia, E.2    Rich, K.3
  • 54
    • 32544435900 scopus 로고    scopus 로고
    • Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: A follow-up study
    • Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol 2006; 5: 228-234.
    • (2006) Lancet Neurol , vol.5 , pp. 228-234
    • Hansson, O.1    Zetterberg, H.2    Buchhave, P.3    Londos, E.4    Blennow, K.5    Minthon, L.6
  • 55
    • 0036338203 scopus 로고    scopus 로고
    • Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231
    • Buerger K, Zinkowski R, Teipel SJ, et al. Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231. Arch Neurol 2002; 59: 1267-1272.
    • (2002) Arch Neurol , vol.59 , pp. 1267-1272
    • Buerger, K.1    Zinkowski, R.2    Teipel, S.J.3
  • 57
    • 37549004296 scopus 로고    scopus 로고
    • Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease
    • Chetelat G, Desgranges B, Landeau B, et al. Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease. Brain 2008; 131: 60-71.
    • (2008) Brain , vol.131 , pp. 60-71
    • Chetelat, G.1    Desgranges, B.2    Landeau, B.3
  • 58
    • 0034974107 scopus 로고    scopus 로고
    • Hippocampal formation glucose metabolism and volume losses in MCI and AD
    • De Santi S, de Leon MJ, Rusinek H, et al. Hippocampal formation glucose metabolism and volume losses in MCI and AD. Neurobiol Aging 2001; 22: 529-539.
    • (2001) Neurobiol Aging , vol.22 , pp. 529-539
    • De Santi, S.1    de Leon, M.J.2    Rusinek, H.3
  • 59
    • 33947261376 scopus 로고    scopus 로고
    • Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease
    • Mosconi L, Sorbi S, de Leon MJ, et al. Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease. J Nucl Med 2006; 47: 1778-1786.
    • (2006) J Nucl Med , vol.47 , pp. 1778-1786
    • Mosconi, L.1    Sorbi, S.2    de Leon, M.J.3
  • 60
    • 31844440459 scopus 로고    scopus 로고
    • Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment
    • de Leon MJ, DeSanti S, Zinkowski R, et al. Longitudinal CSF and MRI biomarkers improve the diagnosis of mild cognitive impairment. Neurobiol Aging 2006; 27: 394-401.
    • (2006) Neurobiol Aging , vol.27 , pp. 394-401
    • de Leon, M.J.1    DeSanti, S.2    Zinkowski, R.3
  • 61
    • 38049100915 scopus 로고    scopus 로고
    • Combined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's disease
    • epub ahead of print
    • Hansson O, Buchhave P, Zetterberg H, Blennow K, Minthon L, Warkentin S. Combined rCBF and CSF biomarkers predict progression from mild cognitive impairment to Alzheimer's disease. Neurobiol Aging 2007. [epub ahead of print].
    • (2007) Neurobiol Aging
    • Hansson, O.1    Buchhave, P.2    Zetterberg, H.3    Blennow, K.4    Minthon, L.5    Warkentin, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.