Biallelic deletion 13q14.3 in patients with chronic lymphocytic leukemia: Cytogenetic, FISH and clinical studies

European Journal of Haematology

Volumn 81, Issue 2, 2008, Pages 94-99

  Chena, Christian ^a   Avalos, Julio Sánchez ^b   Bezares, Raimundo F ^c   Arrossagaray, Guillermo ^a   Turdó, Karina ^d   Bistmans, Alicia ^e   Slavutsky, Irma ^a  

^a INST DE INVEST HEMATOLOGICAS   (Argentina)

^b INSTITUTO ALEXANDER FLEMING   (Argentina)

^c Hospital General De Agudos Teodoro Alvarez   (Argentina)

^d Hospital Aeronautico Central   (Argentina)

^e HOSPITAL RAMOS MEJÍA   (Argentina)

Author keywords

Biallelic deletion 13q14.3; Chromosomes; Chronic lymphocytic leukemia; FISH

Indexed keywords

LACTATE DEHYDROGENASE;

ADULT; AGED; ARTICLE; CHROMOSOME 13Q; CHROMOSOME DELETION; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ASSESSMENT; CLONE; CORRELATION ANALYSIS; CYTOGENETICS; DISEASE COURSE; DNA PROBE; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOLOGICAL PARAMETERS; HUMAN; KARYOTYPE; LYMPHOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROGNOSIS; STATISTICAL SIGNIFICANCE; SURVIVAL;

CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 13; CYTOGENETIC ANALYSIS; DISEASE PROGRESSION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOCYTES; SURVIVAL RATE;

EID: 47649120465     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2008.01086.x     Document Type: Article

References (24)

1. Chiorazzi N, Rai KR, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med 2005 352 : 804 15.
2. Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Paternack BS. Clinical staging of chronic lymphocytic leukemia. Blood 1975 46 : 219 23.
3. Binet J, Auquier A, Dighiero G, et al. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer 1981 48 : 198 206.
4. Hamblin TC, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999 94 : 1848 54.
5. Döhner H, Stilgenbauer S, Benner A, Leupolt E, Kröber A, Bullinger L, Döhner K, Bentz M, Lichter P. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000 343 : 1910 6.
6. Kröber A, Seiler T, Benner A, Bullinger L, Bruckle E, Lichter P, Döhner H, Stilgenbauer S. V(H) mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukaemia. Blood 2002 100 : 1410 6.
7. Crespo M, Bosch F, Villamor N, Bellosillo B, Colomer D, Rozman M, Marcé S, López-Guillermo A, Campo E, Montserrat E. ZAP-70 expression is a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. N Engl J Med 2003 348 : 1764 75.
8. Dewald GW, Brockman SR, Paternoster SF, et al. Chromosome anomalies detected by interphase fluorescence in situ, hybridization: correlation with significant biological features of B-cell chronic lymphocytic leukaemia. Br J Haematol 2003 121 : 287 95.
9. Reddy KS. Chronic lymphocytic leukemia profiled for prognosis using a fluorescence in situ hybridization panel. Br J Haematol 2006 132 : 705 22.
10. Cheson BD, Bennet JM, Grever M, Kay N, Keating MJ, O'Brien S, Rai K. National Cancer Institute sponsored. Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996 87 : 4990 7.
11. Aoun P, Blair HE, Smith LM, Dave BJ, Lynch J, Weisenburger DD, Pavletic SZ, Sanger WG. Fluorescence in situ hybridization detection of cytogenetic abnormalities in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Leuk Lymphoma 2004 45 : 1595 603.
12. An International System for Human Cytogenetic Nomenclature. In : Shaffer LG, Tommerup N, eds. An International System for Human Cytogenetic Nomenclature. Basel : S Karger, 2005 : 6 95.
13. Matutes E, Owusu-Ankomah K, Morilla R, Garcia-Marco J, Houlihan A, Que T, Catovsky D. The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia 1994 8 : 1640 5.
14. H status, and CD38 expression. Blood 2006 108 : 3152 60.
15. Shanafelt TD, Witzig TE, Fink SR, et al. Prospective evaluation of clonal evolution during long-term follow-up of patients with untreated early-stage chronic lymphocytic leukemia. J Clin Oncol 2006 24 : 4634 41.
16. Stilgenbauer S, Sande S, Bullinger L, Benner A, Leupolt E, Winkler D, Kröber A, Kienle D, Lichter P, Döhner H. Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistence to therapy, and short survival. Haematologica 2007 92 : 1242 5.
17. Oscier D, Fitchett M, Herbert T, Lambert R. Karyotypic evolution in B-cell chronic lymphocytic leukaemia. Genes Chromosomes Cancer 1991 3 : 16 20.
18. Nowell PC, Moreau L, Gowney M, Besa EC. Karyotypic stability in chronic B-cell leukemia. Cancer Genet Cytogenet 1988 33 : 155 60.
19. Fegan C, Robinson H, Thompson P, Witaker JA, White D. Karyotypic evolution in CLL: identification of a new-subgroup of patients with deletion of 11q and advanced or progressive disease. Leukemia 1995 9 : 2003 8.
20. Finn WG, Kay NE, Kroft SH, Church S, Paterson AC. Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: a sequential study of karyotypic instability in 51 patients. Am J Hematol 1998 59 : 223 9.
21. Pfeifer D, Pantic M, Skatulla I, Rawluk J, Kreutz C, Martens UM, Fisch P, Timmer J, Veelken H. Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays. Blood 2007 109 : 1202 10.
22. Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletion and down-regulation of micro-RNA genes miR-15 and miR-16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002 99 : 15524 9.
23. Calin GA, Ferracin M, Cimmino A, et al. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 2005 353 : 1793 801.
24. Mertens D, Wolf S, Tschuch C, et al. Allelic silencing at the tumor-suppressor locus 13q14.3 suggests an epigenetic tumor-suppressor mechanism. Proc Natl Acad Sci U S A 2006 103 : 7741 6.