Transient Ischemic Attack: Risk Stratification and Treatment

Annals of Emergency Medicine

Volumn 52, Issue 2, 2008, Pages

  Cucchiara, Brett ^a   Ross, Michael ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; CLOPIDOGREL; DIPYRIDAMOLE; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; PLACEBO; SIMVASTATIN; TICLOPIDINE; WARFARIN;

ARTERY DISSECTION; ARTICLE; BLEEDING; BRAIN HEMORRHAGE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; DRUG DOSE COMPARISON; GASTROINTESTINAL HEMORRHAGE; HEADACHE; HEART ATRIUM FIBRILLATION; HIGH RISK PATIENT; HOSPITALIZATION COST; HUMAN; MEDICAL DECISION MAKING; MONOTHERAPY; NEUROIMAGING; NEUTROPENIA; PRIORITY JOURNAL; RISK ASSESSMENT; STROKE; TRANSIENT ISCHEMIC ATTACK;

ANTICOAGULANTS; ASPIRIN; DRUG THERAPY, COMBINATION; ENDARTERECTOMY, CAROTID; HUMANS; ISCHEMIC ATTACK, TRANSIENT; MAGNETIC RESONANCE IMAGING; PLATELET AGGREGATION INHIBITORS; PRACTICE GUIDELINES AS TOPIC; PROGNOSIS; RISK ASSESSMENT; STROKE; WARFARIN;

EID: 47649116715     PISSN: 01960644     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.annemergmed.2008.05.019     Document Type: Article

References (75)

1. Johnston S.C., Gress D.R., Browner W.S., et al. Short-term prognosis after emergency department diagnosis of transient ischemic attack. JAMA 284 (2000) 2901-2906
2. Rothwell P.M., Giles M.F., Flossmann E., et al. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet 366 (2005) 29-36
3. Johnston S.C., Rothwell P.M., Nguyen-Huynh M.N., et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet 369 (2007) 283-292
4. Tsivgoulis G., Spengos K., Manta P., et al. Validation of the ABCD score in identifying individuals at high early risk of stroke after a transient ischemic attack: a hospital-based case series study. Stroke 37 (2006) 2892-2897
5. Tsivgoulis G., Vassilopoulou S., and Spengos K. Potential applicability of ABCD score in triaging transient ischemic attack patients. Lancet 369 (2007) 1082
6. Bray J.E., Coughlan K., and Bladin C. Can the ABCD score be dichotomised to identify high-risk patients with transient ischaemic attack in the emergency department?. Emerg Med J 24 (2007) 92-95
7. Purroy F., Molina C.A., Montaner J., et al. Absence of usefulness of ABCD score in the early risk of stroke of transient ischemic attack patients. Stroke 38 (2007) 855-856 author reply 857
8. Cucchiara B.L., Messe S.R., Taylor R.A., et al. Is the ABCD score useful for risk stratification of patients with acute transient ischemic attack?. Stroke 37 (2006) 1710-1714
9. Redgrave J.N., Coutts S.B., Schulz U.G., et al. Systematic review of associations between the presence of acute ischemic lesions on diffusion-weighted imaging and clinical predictors of early stroke risk after transient ischemic attack. Stroke 38 (2007) 1482-1488
10. Purroy F., Montaner J., Rovira A., et al. Higher risk of further vascular events among transient ischemic attack patients with diffusion-weighted imaging acute ischemic lesions. Stroke 35 (2004) 2313-2319
11. Coutts S.B., Simon J.E., Eliasziw M., et al. Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging. Ann Neurol 57 (2005) 848-854
12. Boulanger J.M., Coutts S.B., Eliasziw M., et al. Diffusion-weighted imaging-negative patients with transient ischemic attack are at risk of recurrent transient events. Stroke 38 (2007) 2367-2369
13. Redgrave J.N., Schulz U.G., Briley D., et al. Presence of acute ischaemic lesions on diffusion-weighted imaging is associated with clinical predictors of early risk of stroke after transient ischaemic attack. Cerebrovasc Dis 24 (2007) 86-90
14. Calvet D., Lamy C., Touze E., et al. Management and outcome of patients with transient ischemic attack admitted to a stroke unit. Cerebrovasc Dis 24 (2007) 80-85
15. Eliasziw M., Kennedy J., Hill M.D., et al. Early risk of stroke after a transient ischemic attack in patients with internal carotid artery disease. CMAJ 170 (2004) 1105-1109
16. Nguyen-Huynh M.N., and Johnston S.C. Is hospitalization after transient ischemic attack cost-effective on the basis of treatment with TPA?. Neurology 65 (2005) 1799-1801
17. Poisson S.N., Lisabeth L.D., Brown D.L., et al. Effect of hospital admission on stroke risk following transient ischemic attack. Neurology 68 suppl 1 (2007) A193
18. Johnston S.C., Nguyen-Huynh M.N., Schwarz M.E., et al. National Stroke Association guidelines for the management of transient ischemic attacks. Ann Neurol 60 (2006) 301-313
19. Rothwell P.M., Giles M.F., Chandratheva A., et al. Early Use of Existing Strategies for Stroke (EXPRESS) Study. Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke (EXPRESS study): a prospective population-based sequential comparison. Lancet 370 (2007) 1432-1442
20. Lavallée P.C., Mesequer E., Abboud H., et al. A transient ischaemic attack clinic with round-the-clock access (SOS-transient ischemic attack): feasibility and effects. Lancet Neurol 6 (2007) 953-960
21. Goldstein L.B., Bian J., Samsa G.P., et al. New transient ischemic attack and stroke: outpatient management by primary care physicians. Arch Intern Med 160 (2000) 2941-2946
22. Mace S.E., Graff L., Mikhail M., et al. A national survey of observation units in the United States. Am J Emerg Med 21 (2003) 529-533
23. Roberts R.R., Zalenski R.J., Mensah E.K., et al. Costs of an emergency department-based accelerated diagnostic protocol versus hospitalization in patients with chest pain: a randomized controlled trial. JAMA 278 (1997) 1670-1676
24. Gomez M.A., Anderson J.L., Karagounis L.A., et al. An emergency department-based protocol for rapidly ruling out myocardial ischemia reduces hospital time and expense: results of a randomized study (ROMIO). J Am Coll Cardiol 28 (1996) 25-33
25. Ross M.A., Compton S., Medado P., et al. An emergency department diagnostic protocol for patients with transient ischemic attack: a randomized controlled trial. Ann Emerg Med 50 (2007) 109-119
26. Krol A.L., Coutts S.B., Simon J.E., et al., VSG. Perfusion MRI abnormalities in speech or motor transient ischemic attack patients. Stroke 36 (2005) 2487-2489
27. Wojner-Alexander A.W., Garami Z., Chernyshev O.Y., et al. Heads down: flat positioning improves blood flow velocity in acute ischemic stroke. Neurology 64 (2005) 1354-1357
28. Ahmed N., and Wahlgren N.G. Effects of blood pressure lowering in the acute phase of total anterior circulation infarcts and other stroke subtypes. Cerebrovasc Dis 15 (2003) 235-243
29. Oliveira-Filho J., Silva S.C., Trabuco C.C., et al. Detrimental effect of blood pressure reduction in the first 24 hours of acute stroke onset. Neurology 61 (2003) 1047-1051
30. Sherman D.G., Albers G.W., Bladin C., et al. The efficacy and safety of enoxaparin versus unfractionated heparin for the prevention of venous thromboembolism after acute ischaemic stroke (PREVAIL study): an open-label randomised comparison. Lancet 369 (2007) 1347-1355
31. Johnston S.C., Leira E.C., Hansen M.D., et al. Early recovery after cerebral ischemia risk of subsequent neurological deterioration. Ann Neurol 54 (2003) 439-444
32. Wiebers D.O., Whisnant J.P., and O'Fallon W.M. Reversible ischemic neurologic deficit (RIND) in a community: Rochester, Minnesota, 1955-1974. Neurology 32 (1982) 459-465
33. International Stroke Trial Collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet 349 (1997) 1569-1581
34. CAST (Chinese Acute Stroke Trial) Collaborative Group. CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischemic stroke. Lancet 349 (1997) 1641-1649
35. Multicentre Acute Stroke Trial-Italy (MAST-I) Group. Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischemic stroke. Lancet 346 (1995) 1509-1514
36. Chen Z.M., Sandercock P., Pan H.C., et al., CAST and IST Collaborative Groups. Indications for early aspirin use in acute ischemic stroke: a combined analysis of 40000 randomized patients from the Chinese Acute Stroke Trial and the International Stroke Trial. Stroke 31 (2000) 1240-1249
37. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Anonymous. Lancet 2 (1988) 349-360
38. Kennedy J., Hill M.D., Ryckborst K.J., et al. Fast Assessment of Stroke and Transient Ischemic Attack to Prevent Early Recurrence (FASTER): a randomized controlled pilot trial. Lancet Neurol 6 (2007) 961-969
39. Biller J., Bruno A., Adams H.P., et al. A randomized trial of aspirin or heparin in hospitalized patients with recent transient ischemic attacks. A pilot study. Stroke 20 (1989) 441-447
40. Putnam S.F., and Adams H.P. Usefulness of heparin in initial management of patients with recent transient ischemic attacks. Arch Neurol 42 (1985) 960-962
41. Keith D.S., Phillips S.J., Whisnant J.P., et al. Heparin therapy for recent transient focal cerebral ischemia. Mayo Clin Proc 62 (1987) 1101-1106
42. Berge E., and Sandercock P. Anticoagulants versus antiplatelet agents for acute ischaemic stroke. Cochrane Database Syst Rev 4 (2002) CD003242
43. Wong K.S., Chen C., Ng P.W., et al. Low-molecular-weight heparin compared with aspirin for the treatment of acute ischaemic stroke in Asian patients with large artery occlusive disease: a randomised study. Lancet Neurol 6 (2007) 407-413
44. Adams Jr. H.P., Bendixen B.H., Leira E., et al. Antithrombotic treatment of ischemic stroke among patients with occlusion or severe stenosis of the internal carotid artery: a report of the Trial of Org 10172 in Acute Stroke Treatment (TOAST). Neurology 53 (1999) 122-125
45. Rothwell P.M., Eliasziw M., Gutnikov S.A., et al. Endarterectomy for symptomatic carotid stenosis in relation to clinical subgroups and timing of surgery. Lancet 363 (2004) 915-924
46. Alamowitch S., Eliasziw M., Algra A., et al. Risk, causes, and prevention of ischaemic stroke in elderly patients with symptomatic internal-carotid-artery stenosis. Lancet 357 (2001) 1154-1160
47. Lyrer P., and Engelter S. Antithrombotic drugs for carotid artery dissection. Cochrane Database Syst Rev 3 (2003) CD000255
48. Hart R.G., Pearce L.A., and Aguilar M.I. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation. Ann Intern Med 146 (2007) 857-867
49. Mant J., Hobbs F.D., Fletcher K., et al. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged study, BAFTA): a randomised controlled trial. Lancet 370 (2007) 493-503
50. Connolly S., Pogue J., Hart R., et al. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet 367 (2006) 1903-1912
51. Berge E., Abdelnoor M., Nakstad P.H., et al. Low molecular-weight heparin versus aspirin in patients with acute ischaemic stroke and atrial fibrillation: a double-blind randomised study. HAEST Study Group. Heparin in Acute Embolic Stroke Trial. Lancet 355 (2000) 1205-1210
52. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ 324 (2002) 71-86
53. Serebruany V.L., Steinhubl S.R., Berger P.B., et al. Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials. Am J Cardiol 95 (2005) 1218-1222
54. Patrono C., Garcia Rodriguez L.A., Landolfi R., et al. Low dose aspirin for the prevention of atherothrombosis. N Engl J Med 353 (2005) 2373-2383
55. CAPRIE Steering Committee. A randomised, blinded, trial of Clopidogrel versus Aspirin in Patients at Risk of Ischaemic Events (CAPRIE). Lancet 348 (1996) 1329-1339
56. Hass W.K., Easton J.D., Adams H.P., et al. A randomized trial comparing ticlopidine hydrochloride with aspirin for the prevention of stroke in high-risk patients. N Engl J Med 321 (1989) 501-507
57. Gent M., Blakely J.A., Easton J.D., et al. The Canadian American Ticlopidine Study (CATS) in thromboembolic stroke. Lancet 1 (1989) 1215-1220
58. Gorelick P.B., Richardson D., Kelly M., et al. Aspirin and ticlopidine for prevention of recurrent stroke in black patients: a randomized trial. JAMA 289 (2003) 2947-2957
59. Diener H.C., Cunha L., Forbes C., et al. European Stroke Prevention Study 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 143 (1996) 1-13
60. Halkes P.H., van Gijn J., Kappelle L.J., et al. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet 367 (2006) 1665-1673
61. Diener H.C., Bogousslavsky J., Brass L.M., et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 364 (2004) 331-337
62. Bhatt D.L., Fox K.A., Hacke W., et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 354 (2006) 1706-1717
63. Diener H.C., Sacco R., Yusuf S., and Steering Committee and PRoFESS Study Group. Rationale, design and baseline data of a randomized, double-blind, controlled trial comparing two antithrombotic regimens (a fixed-dose combination of extended-release dipyridamole plus ASA with clopidogrel) and telmisartan versus placebo in patients with strokes: the Prevention Regimen for Effectively Avoiding Second Strokes Trial (PRoFESS). Cerebrovasc Dis 23 (2007) 368-380
64. Sacco R.L., Adams R., Albers G., et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Stroke 37 (2006) 577-617
65. Albers G.W., Amarenco P., Easton J.D., et al. Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 126 (2004) 483S-512S
66. Collins R., Armitage J., Parish S., et al. Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions. Lancet 363 (2004) 757-767
67. Amarenco P., Bogousslavsky J., Callahan III A., et al. High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med 355 (2006) 549-559
68. Briel M., Schwartz G.G., Thompson P.L., et al. Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trials. JAMA 295 (2006) 2046-2056
69. Aronow H.D., Novaro G.M., Lauer M.S., et al. In-hospital initiation of lipid-lowering therapy after coronary intervention as a predictor of long-term utilization: a propensity analysis. Arch Intern Med 163 (2003) 2576-2582
70. Cucchiara B., and Kasner S.E. Use of statins in CNS disorders. J Neurol Sci 187 (2001) 81-89
71. Goldstein L.B., and SPARCL Investigators. The SPARCL trial: effect of statins on stroke severity. Ann Neurol 60 suppl 10 (2006) S85
72. Progress Collaborative Group. Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6,105 individuals with previous stroke or transient ischaemic attack. Lancet 358 (2001) 1033-1041
73. Adams Jr. H.P., del Zoppo G., Alberts M.J., et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Circulation 115 (2007) e478-e534
74. Adams Jr. H.P., del Zoppo G., Alberts M.J., et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups. The American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 38 (2007) 1655-1711
75. Hacke W., Donnan G., Fieschi C., et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 363 (2004) 768-774