Effects of total glucosides of paeony on protein expression of NF-kappa B and TGF-β1 in hepatic tissue of rats with immunological hepatic fibrosis

Chinese Pharmacological Bulletin

Volumn 24, Issue 5, 2008, Pages 588-592

  Lu, Jing Tao ^a   Sun, Wu Yi ^a   Liu, Hao ^a   Li, Xiang ^a   Wei, Wei ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Immunological hepatic fibrosis; NF B; TGF 1; TGP

Indexed keywords

COLLAGEN; EOSIN; GLUCOSIDE; HEMATOXYLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PAEONIA RADIX; TRANSCRIPTION FACTOR RELA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; IMAGE ANALYSIS; IMAGING SYSTEM; IMMUNOHISTOCHEMISTRY; LIVER FIBROSIS; NONHUMAN; QUANTITATIVE ANALYSIS; RAT;

EID: 47649115582     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Dai W J, Jiang H C. Advances in gene therapy of liver cirrhosis: A review[J]. World J Gastroenterol,2001;7(1):1-8.
2. Friedman S L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury[J]. J Biol Chem,2000,275(4): 2247-50.
3. Chang Y, Wei W, Zhang L, et al. Effects of TGP on functions of fibroblast-likesynoviocytes under the stimulation of IL-2α in CIA rats [J]. Chin Pharmacol Bull,2007,23(2):185-8.
4. Chen Q, Wei W. Effects and mechanisms of glucosides of chaenomeles speciosa on collagen induced arthritis in rats[J]. Int Immunopharmacol, 2003,3(4):593-608.
5. Wang H, Wei W, Wang N P, et al. Effects of total glucosides of peony on immunological hepatic fibrosis in rats[J]. World J Gastroenterol,2005, 11(14):2124-9.
6. 4-induced liver fibrosis and function of hepatic stellate cells[J]. Chin J New Drugs,2007,16(9):685-7.
7. Luckey S W, Petersen D R. Activation of Kupffer cells during the course of carbon tetrachloride-induced liver injury and fibrosis in rats[J]. Exp Mol Pathol,2001,71(3):226-40.
8. Hellerbrand C, Jobin C, Iimuro Y, et al. Inhibition of NF-kappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor[J]. Hepatology,1998,27(5):1285-95.
9. Bedossa P. Paradis V. Transforming growth factor-beta (TGF-beta): a key role in liver fibrogenesis[J]. J Hepatol,1995,22(2):37-42.
10. Wu Y C, Wu Q, Yang Y, et al. Change of NFkappa B, transforming growth factor beta-1 in the development of rat hepatic fibrosis and effect of Liver-aid Tablets on them[J]. J Chin Antitub Associ,2007,29(8):317-20.
11. Yu S Y, Ben C E, Yang M J, et al. Comparison between immunological and chemical injury hepatic fibrosis animal models[J]. Lab Anim Sci Admin,1995,12(4):5-11.
12. Zhai W R, Wang T L, Zhou X J, Zhang T H. Diagnisis, grading and staging of chronic hehatitis[J]. Chin J Dig,1996,16(5):277-80.
13. Koziel M J. The immmopathogenesis of HBV infection[J]. Antivir Ther,1998,3(suppl 3):13-24.
14. Mirza A, Liu S L, Frizell E, et al. A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB[J]. Am J Physiol,1997,272(2):G281-8.
15. Breitkopf K, Haas S, Wiercinska E, et al. Anti-TGF-beta strategies for the treatment of chronic liver disease[J]. Alcohol Clin Exp Res, 2005,29(suppl 11):121-31.
16. Lawrence D A. Transforming growth factor-beta: an overview[J]. Kidney Int Suppl,1995,49(8):19-23.