Nootropic signal transduction of ginsenoside Rg1

Chinese Pharmacological Bulletin

Volumn 24, Issue 6, 2008, Pages

  Wang, Yu Zhu ^a   Wang, Yong Sheng ^a   Chu, Shi Feng ^a   Chen, Ji ^a   Chen, Nai Hong ^a   Zhang, Jun Tian ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

cAMP; Cognitive function; Ginsenoside Rg1; p CREB; PDE; Signal transduction

Indexed keywords

CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GINSENOSIDE RG 1; PHOSPHODIESTERASE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; BRAIN HOMOGENATE; COGNITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

EID: 47649094433     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Haus-Seuffert P, Meisterernst M. Mechanisms of transcriptional activation of cAMP responsive element-binding protein CREB[J]. Mol Cell Biochem, 2000,212(1-2): 5-9.
2. Sands W A, Palmer T M. Regulating gene transcription in response to cyclic AMP elevation[J]. Cell Signal, 2008,20(3):460-6.
3. Warburton E C, Glover C P, Massey PV, et al. cAMP Responsive Element-Binding Protein Phosphorylation Is Necessary for Perirhinal Long-Term Potentiation and Recognition Memory[J]. J Neurosci, 2005,25(27): 6296-303.
4. Leung K W, Yung K K, Mak N K, et al. Neuroprotective effects of ginsenoside-Rg1 in primary nigral neurons against rotenone toxicity[J]. Neuropharmacology, 2007,52(3):827-35.
5. 25-35 [J]. Chin Pharmacol Bull,2007,23(5):612-7.
6. Cheng Y, Shen L H, Zhang J T. Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action [J]. Acta Pharmacol Sin, 2005,26(2):143-9.
7. Yang Y, Zhang JT, Shi C Z, et al. Study on the nootropic mechanism of ginsenoside Rb1 and Rg1-influence on mouse brain development[J]. Acta Pharmaceu Sin, 1994,29(4):241-5.
8. Wang X Y, Zhang J T. NO mediates ginsenoside Rg1-induced long-term potentiation in anesthetized rats[J]. Acta Pharmacol Sin, 2001,22(12):1099-102.
9. Wang X Y, Zhang J T. Effects of ginsenoside Rg1 on synaptic plasticity of freely moving rats and its mechanism of action[J]. Acta Pharmacol Sin, 2001,22(7), 657-62.
10. Jin R, Ma X, Jiang XY, et al. Effects of activating gamma - hydroxybutyric acid receptor on neuronal apoptosis following focal cerebral ischemia-reperfusion injury in rats[J]. Chin Pharmacol Bull,2007, 23(7):874-7.
11. Chen Y, Li Z G, Tang H F, Chen J Q. The effects of rolipram on PDE activity and IL-4 level in the lung tissue of ovalbumin sensitized and repeatedly challenged rats[J]. Chin Pharmacol Bull, 2006,22(4): 447-51.
12. Liu M, Zhang J T. Effects of ginsenoside Rg1 on c-fos gene expression and cAMP levels in rat hippocampus[J]. Acta Pharmacol Sin, 1996,17(2):171-4.
13. Stancheva S L, Alova L G. Ginsenoside Rg1 inhibits the brain cAMP phosphodiesterase activity in young and aged rats[J]. Gen Pharmacol, 1993,24(6):1459-62.
14. Nah S Y, Oh S. Modulation of G Protein a-Subunit mRNA Levels in Discrete Rat Brain Regions by Cerebroventricular Infusion of Ginsenoside Rc and Rg1[J]. Neurochem Res, 2003,28(5):691-7.