Effects of ginsenoside Rg1 on c-fos gene expression and cAMP levels in rat hippocampus

Acta Pharmacologica Sinica

Volumn 17, Issue 2, 1996, Pages 171-174

  Liu, Min ^a   Zhang, Jun Tian ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

cyclic AMP; fos genes; ginseng; hippocampus; Northern blotting; proto oncogene proteins c fos; saponins; Western blotting

Indexed keywords

CYCLIC AMP; GINSENOSIDE RG 1; MESSENGER RNA; NOOTROPIC AGENT; PROTEIN C FOS; GINSENOSIDE; SAPONIN;

AGE; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOBLOTTING; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; NORTHERN BLOTTING; RAT; AGING; ANIMAL; BIOSYNTHESIS; DRUG EFFECT; GINSENG; MEDICINAL PLANT; METABOLISM; ONCOGENE; WISTAR RAT;

AGING; ANIMALS; CYCLIC AMP; GENE EXPRESSION; GENES, FOS; GINSENOSIDES; HIPPOCAMPUS; MALE; NOOTROPIC AGENTS; PANAX; PLANTS, MEDICINAL; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; SAPONINS;

EID: 0029968938     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Curran T, Franza BR Jr. Fos and Jun: the AP-1 connection. Cell 1988; 55: 395-7.
2. Sager SM, Sharp FR, Curran T. Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science 1988; 240: 1328-31.
3. Sheng M, Greenberg ME. The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 1990; 4: 477-85.
4. Ran W, Dean M, Levine RA, Henkle C, Campisi J. Induction of c-fos and c-myc mRNA by epidermal growth factor or calcium ionophore is cAMP dependent. Proc Natl Acad Sci USA 1986; 83: 8216-20.
5. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-9.
6. Müller R, Bravo R, Burckhardt J. Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature 1984;312: 716-9.
7. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning, a laboratory manual. 2nd ed. New York: Cold Spring Harbor Laboratory Press, 1989; 888-94.
8. Shimizu H, Daly JW, Creveling CR. A radioisotopic method for measuring the formation of adenosine 3′, 5′-cyclic monophosphate in incubated slices of brain. J Neurochem 1969; 16: 1609-19.
9. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement wirh the Folin phenol reagent. J Biol Chem 1951; 193: 265-75.
10. Puri SK, Volicer L. Age-related changes of cyclic nucleotide levels in rat brain regions. Mech Aging Dev 1981; 15: 239-42.
11. Kaczmarek L. Molecular biology of vertebrate learning: Is c-fos a new beginning? J Neurosci Res 1993; 34: 377-81.
12. Kitraki E, Bozas E, Philippidis H, Stylianopoulou F. Aging-related changes in IGF-II and c-fos gene expression in the rat brain. Int J Dev Neuroscience 1993; 11: 1-9.
13. Sassone-Corsi P, Visvader J, Ferland L, Mellon PL, Verma IM. Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element. Genes Dev 1988; 2: 1529-38.