Reduced expression of low-density lipoprotein receptor in hepatocellular carcinoma with paraneoplastic hypercholesterolemia

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue 7 PT2, 2008, Pages

  Sohda, Tetsuro ^a   Iwata, Kaoru ^a   Kitamura, Yuji ^a   Suzuki, Norihisa ^a   Takeyama, Yasuaki ^a   Irie, Makoto ^a   Anan, Akira ^a   Nakane, Hidetoshi ^a   Yoshikane, Makoto ^a   Watanabe, Hiroshi ^a   Sakisaka, Shotaro ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

Chromosome 19p13.2; Hepatocellular carcinoma; Hypercholesterolemia; Loss of heterozygosity; Low density lipoprotein receptor; Paraneoplastic syndrome

Indexed keywords

DNA; FLUORESCEIN ISOTHIOCYANATE; LOW DENSITY LIPOPROTEIN RECEPTOR; MONOCLONAL ANTIBODY; PARAFFIN;

ADULT; AGED; ARTICLE; AUTOPSY; CARCINOMA CELL; CELL SURFACE; CHROMOSOME 19P; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DNA DETERMINATION; DNA EXTRACTION; FEMALE; GENE LOCATION; GENOMICS; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER BIOPSY; LIVER CELL; LIVER CELL CARCINOMA; MALE; MICROSATELLITE MARKER; PARANEOPLASTIC SYNDROME; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR GENE;

EID: 47649085034     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2007.05115.x     Document Type: Article

References (19)

1. Okuda K. Primary liver cancer. Quadrennial review lecture. Dig. Dis. Sci. 1986 31 : 133S 146S.
2. Hwang SJ, Lee SD, Chang CF et al. Hypercholesterolemia in patients with hepatocellular carcinoma. J. Gastroenterol. Hepatol. 1992 7 : 491 6.
3. Hwang SJ, Lee SD, Wu JC et al. Clinical evaluation of erythrocytosis in patients with hepatocellular carcinoma. Zhonghua Yi Xue Za Zhi (Taipei) 1994 53 : 262 9.
4. Luo JC, Hwang SJ, Wu JC et al. Paraneoplastic syndromes in patients with hepatocellular carcinoma in Taiwan. Cancer 1999 86 : 799 804.
5. Sohda T, Yun K, Iwata K, Okumura M. Increased expression of insulin-like growth factor 2 in hepatocellular carcinoma is primarily regulated at the transcriptional level. Lab. Invest. 1996 75 : 307 11.
6. Yen TC, Hwang SJ, Wang CC, Lee SD, Yeh SH. Hypercalcemia and parathyroid hormone-related protein in hepatocellular carcinoma. Liver 1993 13 : 311 15.
7. Sakisaka S, Watanabe M, Tateishi H et al. Erythropoietin production in hepatocellular carcinoma cells associated with polycythemia: immunohistochemical evidence. Hepatology 1993 18 : 1357 62.
8. Pedersen TR. Lowering cholesterol with drugs and diet. N. Engl. J. Med. 1995 333 : 1350 1.
9. Goldstein JL, Sobhani MK, Faust JR, Brown MS. Heterozygous familial hypercholesterolemia: failure of normal allele to compensate for mutant allele at a regulated genetic locus. Cell 1976 9 : 195 203.
10. Goldstein JL, Brown MS. The LDL receptor locus and the genetics of familial hypercholesterolemia. Ann. Rev. Genet. 1979 13 : 259 89.
11. Knight BL, Patel DD, Soutar AK. The regulation of 3-hydroxy-3- methylglutaryl-CoA reductase activity, cholesterol esterification and the expression of low-density lipoprotein receptors in cultured monocyte-derived macrophages. Biochem. J. 1983 210 : 523 32.
12. Brown MS, Goldstein JL. Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein. Cell 1976 9 : 663 74.
13. Maartmann-Moe K, Berg-Johnsen P. Genetics of the low density lipoprotein receptor: I. Low density lipoprotein receptor activity in cultured fibroblasts from subjects with or without familial hypercholesterolemia. Clin. Genet. 1981 20 : 90 103.
14. Bilheimer DW, Ho YK, Brown MS, Anderson RG, Goldstein JL. Genetics of the low density lipoprotein receptor. Diminished receptor activity in lymphocytes from heterozygotes with familial hypercholesterolemia. J. Clin. Invest. 1978 61 : 678 96.
15. Goldstein JL, Kottke BA, Brown MS. Biochemical genetics of LDL receptor mutations in familial hypercholesterolemia. Prog. Clin. Biol. Res. 1982 103 : 161 76.
16. Qin LX, Tang ZY, Sham JS et al. The association of chromosome 8p deletion and tumor metastasis in human hepatocellular carcinoma. Cancer Res. 1999 59 : 5662 5.
17. Okabe H, Ikai I, Matsuo K et al. Comprehensive allelotype study of hepatocellular carcinoma: potential differences in pathways to hepatocellular carcinoma between hepatitis B virus-positive and -negative tumors. Hepatology 2000 31 : 1073 9.
18. Qin LX, Tang ZY, Ye SL et al. Chromosome 8p deletion is associated with metastasis of human hepatocellular carcinoma when high and low metastatic models are compared. J. Cancer Res. Clin. Oncol. 2001 127 : 482 8.
19. Zhang LH, Qin LX, Ma ZC et al. Allelic imbalance regions on chromosomes 8p, 17p and 19p related to metastasis of hepatocellular carcinoma: comparison between matched primary and metastatic lesions in 22 patients by genome-wide microsatellite analysis. J. Cancer Res. Clin. Oncol. 2003 129 : 279 86.