Pretreatment of macrophages with the combination of IFN-γ and IL-12 induces resistance to Leishmania major at the early phase of infection

Journal of Veterinary Medical Science

Volumn 70, Issue 6, 2008, Pages 589-593

  Ota, Haruko ^a   Takashima, Yasuhiro ^b   Matsumoto, Yoshitsugu ^a   Hayashi, Yoshihiro ^a   Matsumoto, Yasunobu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b GIFU UNIVERSITY   (Japan)

Author keywords

Interferon ; Interleukin 12; Leishmania; Macrophage

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; COMPARATIVE STUDY; FEMALE; IMMUNOLOGY; IMMUNOTHERAPY; INNATE IMMUNITY; LEISHMANIA MAJOR; MACROPHAGE; METHODOLOGY; MOUSE; PARASITOLOGY; SKIN LEISHMANIASIS;

ANALYSIS OF VARIANCE; ANIMALS; FEMALE; IMMUNITY, NATURAL; IMMUNOTHERAPY; INTERFERON TYPE II; INTERLEUKIN-12; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MACROPHAGES; MICE; MICE, INBRED BALB C;

LEISHMANIA MAJOR;

EID: 47549118921     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.70.589     Document Type: Article

References (21)

1. Akivov, O.E., Kasuboski, R.E., Carter, C.R. and McDowell, M.A. 2007. The role of mannose receptor during experimental leishmanaiasis. J. Leukoc. Biol. 81: 1188-1196.
2. Alexander, J., Satoskar, A.R. and Russell, D.G. 1999. Leishmania species: models of intracellular parasitism. J. Cell Sci. 112: 2993-3002.
3. Flynn, J.L., Chan, J., Triebold, K.J., Dalton, D.K., Stewart, T.A. and Bloom, B.R. 1993. An essential role for interferon ? in resistance to Mycobacterium tuberculosis infection. J. Exp. Med. 178: 2249-2254.
4. Gazzinelli, R.T., Wysocka, M., Hayashi, S., Denkers, E.Y., Hieny, S., Caspar, P., Trinchieri, G. and Sher, A. 1994. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153: 2533-2543.
5. Green, S.J., Crawford, R.M., Hockmeyer, J.T., Meltzer, M.S. and Nacy, C.A. 1990. Leishmania major amastigotes initiate the L-arginine-dependent killing mechanism in IFN-γ-stimulated macrophages by induction of tumor necrosis factor-α. J. Immunol. 145: 4290-4297.
6. Heinzel, F.P., Sadick, M.D, Holaday, B.J., Coffman, R.L. and Locksley, R.M. 1989. Reciprocal expression of interferon-γ or interleukin-4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T-cell subsets. J. Exp.Med. 169: 59-72.
7. Heinzel, F.P., Schoenhaut, D.S., Rerko, R.M., Rosser, L.E. and Gately, M.K. 1993. Recombinant Interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177: 1505-1509.
8. Kobayashi, M., Fitz, L., Ryan, M., Hewick, R.M., Clark, S.C., Chan, S., Loudon, R., Sherman, F., Perussia, B. and Trinchieri, G. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170: 827-845.
9. Martinez-Pomares, L., Reid, D.M., Brown, G.D., Taylor, P.R., Stillion, R.J., Linehan, S.A., Zamze, S., Gordon, S. and Wong, S.Y.C. 2003. Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodies. J. Leukoc. Immunol. 73: 604-613.
10. Marzio, P.D., Puddu, P., Conti, L., Belardelli, F. and Gessani, S. 1994. Interferon-γ upregulates its own gene expression in mouse peritoneal macrophages. J. Exp. Med. 179: 1731-1736.
11. Mattner, F., Padova, K.D. and Alber, G. 1997. Interleukin-12 is indispensable for protective immunity against Leishmania major. Infect. Immun. 65: 4378-4383.
12. Mosser, D.M. and Edelson, P.J. 1985. The mouse macrophage receptor for C3bi (CR3) is a major mechanism in the phagocytsis of Leishmania promastigotes. J. Immunol. 135: 2785-2789.
13. Munder, M., Mallo, M., Eichmann, K. and Modolell, M. 1998. Murine macrophages secrete Interferon γ upon combined stimulation with Interleukin (IL)-12 and IL18: a novel pathway of autocrine macrophage activation. J. Exp. Med. 187: 2103-2108.
14. Puddu, P., Fantuzzi, L., Borghi, P., Varano, B., Rainaldi, G., Guillemard, E., Malorni, W., Nicaise, P., Wolf, S.F., Belardelli, F. and Gessani, S. 1997. IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages. J. Immunol. 159: 3490-3497.
15. Sadick, M.D., Heinzel, F.P., Holaday, B.J., Pu, R.T., Dawkins, R.S. and Locksle, R.M. 1990. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. J. Exp. Med. 171: 115-127.
16. Schlesinger, L.S. and Horwitz, M.A. 1991. Phagocytosis of Mycobacterium leprae by human monocyte-derived macrophages is mediated by comprement receptors CR1 (CD35), CR3 (CD11b/CD18), and CR4 (CD11c/CD18) and IFN-γ activation inhibits complement receptor function and phagocytosis of this bacterium. J. Immunol. 147: 1983-1994.
17. Scott, P., Natovitz, P., Coffman, R.L., Pearce, E. and Sher, A. 1988. Immunoregulation of cutaneous leishmaniasis. T-cell lines that transfer protective immunity or exacerbation belong to different T-helper subsets and respond to distinct parasite antigens. J. Exp.Med. 168: 1675-1684.
18. Scott, P. 1991. IFN-γ modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J. Immunol. 147: 3149-3155.
19. Scott, P. 1993. IL-12: initiation cytokine for cell-mediated immunity. Science 260: 496-497.
20. + T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. U.S.A. 90: 10188-10192.
21. Stenger, S., Thuring, H., Rollinghoff, M. and Bogdan, C. 1994. Tissue expression of inducible nitric oxide synthesis is closely associated with resistance to Leishmania major. J. Exp. Med. 180: 783-793.