Monoallelic or biallelic LMO2 expression in relation to the LMO2 rearrangement status in pediatric T-cell acute lymphoblastic leukemia

Leukemia

Volumn 22, Issue 7, 2008, Pages 1434-1437

  Van Vlierberghe, P ^a   Beverloo, H B ^b   Buijs Gladdines, J ^a   van Wering, E R ^c   Horstmann, M ^d   Pieters, R ^a   Meijerink, J P P ^a  

^a SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c Dutch Childhood Oncology Group DCOG   (Netherlands)

^d German Cooperative Study Group for Childhood Acute Lymphoblastic Leukemia (COALL)   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LIM DOMAIN ONLY 2 PROTEIN; LIM PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; BACTERIAL ARTIFICIAL CHROMOSOME; CHILD; CHROMOSOME TRANSLOCATION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE DELETION; GENE EXPRESSION; GENE REARRANGEMENT; HUMAN; LETTER; LEUKEMOGENESIS; LYMPHOCYTOPOIESIS; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; T CELL LEUKEMIA;

ALLELES; CHILD, PRESCHOOL; DNA-BINDING PROTEINS; GENE DELETION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA-LYMPHOMA, ADULT T-CELL; METALLOPROTEINS; NUCLEIC ACID AMPLIFICATION TECHNIQUES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TRANSLOCATION, GENETIC;

EID: 47549109069     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2405063     Document Type: Letter

References (10)

1. Graux C, Cools J, Michaux L, Vandenberghe P, Hagemeijer A. Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: From thymocyte to lymphoblast. Leukemia 2006; 20: 1496-1510.
2. Hammond SM, Crable SC, Anderson KP. Negative regulatory elements are present in the human LMO2 oncogene and may contribute to its expression in leukemia. Leuk Res 2005; 29: 89-97.
3. Van Vlierberghe P, van Grotel M, Beverloo HB, Lee C, Helgason T, Buijs-Gladdines J et al. The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia. Blood 2006; 108: 3520-3529.
4. Dik WA, Nadel B, Przybylski GK, Asnafi V, Grabarczyk P, Navarro JM et al. Different chromosomal breakpoints impact the level of LMO2 expression in T-ALL. Blood 2007; 110: 388-392.
5. Schouten JP, McElgunn CJ, Waaijer R, Zwijnenburg D, Diepvens F, Pals G. Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res 2002; 30: E57.
6. Redon R, Ishikawa S, Fitch KR, Feuk L, Perry GH, Andrews TD et al. Global variation in copy number in the human genome. Nature 2006; 444: 444-454.
7. Ferrando AA, Herblot S, Palomero T, Hansen M, Hoang T, Fox EA et al Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Blood 2004; 103 1909-1911.
8. Pike-Overzet K, de Ridder D, Weerkamp F, Baert MR, Verstegen MM, Brugman MH et al. Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy. Leukemia 2007; 21: 754-763.
9. Herblot S, Steff AM, Hugo P, Aplan PD, Hoang T. SCL and LMO1 alter thymocyte differentiation: Inhibition of E2A-HEB function and pre-T alpha chain expression. Nat Immunol 2000; 1: 138-144.
10. Asnafi V, Beldjord K, Libura M, Villarese P, Millien C, Ballerini P et al. Age-related phenotypic and oncogenic differences in T-cell acute lymphoblastic leukemias may reflect thymic atrophy. Blood 2004; 104: 4173-4180.