Behavioural studies using temporal and spatial inactivation of the oxytocin receptor

Progress in Brain Research

Volumn 170, Issue , 2008, Pages 73-77

  Lee, Heon Jin ^a   Caldwell, Heather K ^b   Macbeth, Abbe H ^a   Young III, W Scott ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b KENT STATE UNIVERSITY   (United States)

Author keywords

behaviour; Camk2a; conditional; Cre; knockout; Oxtr; oxytocin; transgenic

Indexed keywords

CRE RECOMBINASE; OXYTOCIN; OXYTOCIN RECEPTOR; PROTEIN KINASE (CALCIUM,CALMODULIN) II;

BEHAVIORAL RESEARCH; BRAIN DEVELOPMENT; CENTRAL NERVOUS SYSTEM; DNA FLANKING REGION; ELECTROENCEPHALOGRAM; EXON; GENE EXPRESSION; GENE SEQUENCE; GENE TARGETING; GENETIC CODE; GIANT CELL; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; SIGNAL TRANSDUCTION; SPATIAL ORIENTATION; SUPRAOPTIC NUCLEUS; TEMPORAL LOBE; THALAMUS MIDLINE NUCLEUS;

ANIMALS; BEHAVIOR, ANIMAL; GENE EXPRESSION REGULATION; MICE; MICE, KNOCKOUT; PHENOTYPE; RECEPTORS, OXYTOCIN; RECOGNITION (PSYCHOLOGY); SPACE PERCEPTION; TIME PERCEPTION;

EID: 47549100830     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(08)00407-X     Document Type: Review

References (26)

1. Amico J.A., Vollmer R.R., Cai H.M., Miedlar J.A., and Rinaman L. Enhanced initial and sustained intake of sucrose solution in mice with an oxytocin gene deletion. Am. J. Physiol. Regul. Integr. Comp. Physiol. 289 (2005) R1798-R1806
2. Auranen M., Vanhala R., Varilo T., Ayers K., Kempas E., Ylisaukko-Oja T., Sinsheimer J.S., Peltonen L., and Jarvela I. A genomewide screen for autism-spectrum disorders: evidence for a major susceptibility locus on chromosome 3q25-27. Am. J. Hum. Genet. 71 (2002) 777-790
3. Broach J.R., and Hicks J.B. Replication and recombination functions associated with the yeast plasmid, 2 mu circle. Cell 21 (1980) 501-508
4. Brownstein M.J., Russell J.T., and Gainer H. Synthesis, transport, and release of posterior pituitary hormones. Science 207 (1980) 373-378
5. Caldwell H.K., and Young III W.S. Oxytocin and vasopressin: genetics and behavioral implications. In: Lim R. (Ed). Neuroactive Proteins and Peptides (2006), Springer, New York 573-607
6. Dragatsis I., and Zeitlin S. CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain. Genesis 26 (2000) 133-135
7. Ferguson J.N., Young L.J., Hearn E.F., Matzuk M.M., Insel T.R., and Winslow J.T. Social amnesia in mice lacking the oxytocin gene. Nat. Genet. 25 (2000) 284-288
8. Gaveriaux-Ruff C., and Kieffer B.L. Conditional gene targeting in the mouse nervous system: insights into brain function and diseases. Pharmacol. Ther. 113 (2007) 619-634
9. Gimpl G., and Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol. Rev. 81 (2001) 629-683
10. Gould B.R., and Zingg H.H. Mapping oxytocin receptor gene expression in the mouse brain and mammary gland using an oxytocin receptor-LacZ reporter mouse. Neuroscience 122 (2003) 155-167
11. Insel T.R., Gelhard R., and Shapiro L.E. The comparative distribution of forebrain receptors for neurohypophyseal peptides in monogamous and polygamous mice. Neuroscience 43 (1991) 6233-6630
12. Jacob S., Brune C.W., Carter C.S., Leventhal B.L., Lord C., and Cook Jr. E.H. Association of the oxytocin receptor gene (Oxtr) in Caucasian children and adolescents with autism. Neurosci. Lett. 417 (2007) 6-9
13. Lee, H.J., Caldwell, H.K., Macbeth, A.H., Tolu, S.G. and Young W.S., III (2008) A conditional knockout mouse line of the oxytocin receptor. Endocrinology [Epub Mar 20].
14. Lewandoski M. Conditional control of gene expression in the mouse. Nat. Rev. Genet. 2 (2001) 743-755
15. Mansour S.L., Thomas K.R., and Capecchi M.R. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336 (1988) 348-352
16. Mantella R.C., Vollmer R.R., Li X., and Amico J.A. Female oxytocin-deficient mice display enhanced anxiety-related behavior. Endocrinology 144 (2003) 2291-2296
17. Morozov A., Kellendonk C., Simpson E., and Tronche F. Using conditional mutagenesis to study the brain. Biol. Psychiatry 54 (2003) 1125-1133
18. Nishimori K., Young L.J., Guo Q., Wang Z., Insel T.R., and Matzuk M.M. Oxytocin is required for nursing but is not essential for parturition or reproductive behavior. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 11699-11704
19. Shao Y., Wolpert C.M., Raiford K.L., Menold M.M., Donnelly S.L., Ravan S.A., Bass M.P., McClain C., von Wendt L., Vance J.M., Abramson R.H., Wright H.H., Ashley-Koch A., Gilbert J.R., DeLong R.G., Cuccaro M.L., and Pericak-Vance M.A. Genomic screen and follow-up analysis for autistic disorder. Am. J. Med. Genet. 114 (2002) 99-105
20. Sternberg N., and Hamilton D. Bacteriophage P1 site-specific recombination. I. Recombination between loxP sites. J. Mol. Biol. 150 (1981) 467-486
21. Takayanagi Y., Yoshida M., Bielsky I.F., Ross H.E., Kawamata M., Onaka T., Yanagisawa T., Kimura T., Matzuk M.M., Young L.J., and Nishimori K. Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 16096-16101
22. Thompson S., Clarke A.R., Pow A.M., Hooper M.L., and Melton D.W. Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells. Cell 56 (1989) 313-321
23. Wu S., Jia M., Ruan Y., Liu J., Guo Y., Shuang M., Gong X., Zhang Y., Yang X., and Zhang D. Positive association of the oxytocin receptor gene (Oxtr) with autism in the Chinese Han population. Biol. Psychiatry 58 (2005) 74-77
24. Young L.J., Pitkow L.J., and Ferguson J.N. Neuropeptides and social behavior: animal models relevant to autism. Mol. Psychiatry 7 Suppl 2 (2002) S38-S39
25. Young III W.S., and Gainer H. Transgenesis and the study of expression, cellular targeting and function of oxytocin, vasopressin and their receptors. Neuroendocrinology 78 (2003) 185-203
26. Young III W.S., Shepard E., Amico J., Hennighausen L., Wagner K.U., LaMarca M.E., McKinney C., and Ginns E.I. Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition. J. Neuroendocrinol. 8 (1996) 847-853