A synthesis of licofelone using Fenton's reagent

Tetrahedron Letters

Volumn 49, Issue 36, 2008, Pages 5316-5318

  Rádl, Stanislav ^a   Černý, Josef ^a   Klecán, Ondřej ^a   Stach, Jan ^a   Plaček, Lukáš ^a   Mandelová, Zuzana ^a  

^a Zentiva Prague   (Czech Republic)

Author keywords

Fenton's reagent; Licofelone; Licofelone amide; Licofelone esters; Licofelone nitrile; Radical reaction; Spectral characterization

Indexed keywords

2,3 DIHYDRO 1H PYRROLIZINE; BROMOACETIC ACID; FERROUS GLUCONATE; IODOACETIC ACID; IODOACETONITRILE; LICOFELONE; NITRILE; PYRROLIZINE DERIVATIVE; SODIUM IODIDE;

ALKYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DECARBOXYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED RADIATION; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE; SAPONIFICATION; ULTRAVIOLET RADIATION;

EID: 47549094297     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.06.078     Document Type: Article

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25. 4, and evaporated under reduced pressure. The obtained residue was crystallized from ethanol to afford the desired product 4.
26. 4, and evaporated under reduced pressure. The residue was crystallized from ethanol to give the desired product 4.
27. 4 and evaporated under reduced pressure. The residue was crystallized from ethanol to afford 1.46 g (65%) of the desired product 5.
28. 2 (M+H) 408.17303, found 408.17255.
29. 2 (M+H) 394.15738, found 394.15671.
30. 2 (M+H) 436.19651, found 436.20374.
31. 2 (M+H) 361.14715, found 361.14664.
32. 2O (M+H) 379.15771, found 379.15744.
33. 2 (M+H) 380.14173, found 380.14117.