cAMP/PKA signaling underlies age-related memory impairment

Brain and Nerve

Volumn 60, Issue 7, 2008, Pages 717-724

  Yamazaki, Daisuke ^a,b   Saitoe, Minoru ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b TOKYO METROPOLITAN UNIVERSITY   (Japan)

Author keywords

Age related memory impairment (AMI); cAMP PKA signaling; Drosophila; Lifespan

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE;

AGING; ALZHEIMER DISEASE; ARTICLE; CEREBROVASCULAR DISEASE; DC0 GENE; DROSOPHILA; ENZYME ACTIVITY; GENE; GENE MUTATION; HETEROZYGOSITY; LEARNING; LIFESPAN; MEMORY; MEMORY DISORDER; NONHUMAN; ONSET AGE; PARKINSON DISEASE; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION;

AGING; ANIMALS; BRAIN; CASEIN KINASE IEPSILON; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HETEROZYGOTE; HUMANS; LEARNING; MEMORY; MEMORY DISORDERS; MODELS, GENETIC; MUTATION; SIGNAL TRANSDUCTION;

EID: 47549084056     PISSN: 18816096     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R: A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464, 1993
2. Burke SN, Barnes CA: Neural plasticity in the ageing brain. Nat Rev Neurosci 7: 30-40, 2006
3. Foster TC: Involvement of hippocampal synaptic plasticity in age-related memory decline. Brain Res Brain Res Rev 30: 236-249, 1999
4. Thibault O, Landfield PW: Increase in single L-type calcium channels in hippocampal neurons during aging. Science 272: 1017-1020, 1996
5. Disterhoft JF, Oh MM: Learning, aging and intrinsic neuronal plasticity. Trends Neurosci 29: 587-599, 2006
6. Tamura T, Chiang AS, Ito N, Liu HP, Horiuchi J, et al: Aging specifically impairs amnesiac-dependent memory in Drosophila. Neuron 40: 1003-1011, 2003
7. Lane ME, Kalderon D: Genetic investigation of cAMP-dependent protein kinase function in Drosophila development. Genes Dev 7: 1229-1243, 1993
8. Drain P, Folkers E, Quinn WG: cAMP-dependent protein kinase and the disruption of learning in transgenic flies. Neuron 6: 71-82, 1991
9. Eckles-Smith K, Clayton D, Bickford P, Browning M D: Caloric restriction prevents age-related deficits in LTP and in NMDA receptor expression. Brain Res Mol Brain Res 78: 154-162, 2000
10. Yamazaki D, Horiuchi J, Nakagami Y, Nagano S, Tamura T, et al: The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan. Nat Neurosci 10: 478-484, 2007
11. Mouravlev A, Dunning J, Young D, During MJ: Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats. Proc Natl Acad Sci U S A 103: 4705-4710, 2006
12. Yin JC, Wallach JS, Del Vecchio M, Wilder EL, Zhou H, et al: Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79: 49-58, 1994
13. Mery F: Aging and its differential effects on consolidated memory forms in Drosophila. Exp Gerontol 42: 99-101, 2007
14. Davare MA, Hell JW: Increased phosphorylation of the neuronal L-type Ca(2+) channel Ca(v)1.2 during aging. Proc Natl Acad Sci U S A 100: 16018-16023, 2003
15. Deyo RA, Straube KT, Disterhoft JF: Nimodipine facilitates associative learning in aging rabbits. Science 243: 809-811, 1989
16. + channel SK3 generates age-related memory and LTP deficits. Nat Neurosci 6: 911-912, 2003