Determining the critical micelle concentration of a novel lipid-lowering agent, disodium ascorbyl phytostanyl phosphate (FM-VP4), using a fluorescence depolarization procedure

Drug Development and Industrial Pharmacy

Volumn 30, Issue 7, 2004, Pages 725-730

  Wasan, Kishor M ^a   Choo, Eugene ^a   Sivak, Olena ^a   Wallis, Simon ^b   Letchford, Kevin ^a   Burt, Helen M ^a   Stewart, David J ^b   Lukic, Tatjana ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Forbes Medi Tech Inc   (Canada)

Author keywords

Critical micelle concentration; Disodium ascorbyl phytostanyl phosphate; Fluorescence depolarization procedure; Novel lipid lowering agent

Indexed keywords

1,6 DIPHENYL 1,3,5 HEXATRIENE; ANTILIPEMIC AGENT; DISODIUM ASCORBYL PHYTOSTANYL PHOSPHATE; DODECYL SULFATE SODIUM; FM VP4; NEW DRUG; STEROL DERIVATIVE; TETRAHYDROFURAN; UNCLASSIFIED DRUG;

ANALYZER; ARTICLE; CONCENTRATION (PARAMETERS); CRITICAL MICELLE CONCENTRATION; DEPOLARIZATION; DRUG STRUCTURE; FLUORESCENCE; FLUORESCENCE DEPOLARIZATION; HYDROPHOBICITY; MICELLE; MICROTITER PLATE ASSAY; TECHNIQUE; TRANSMISSION ELECTRON MICROSCOPY;

CHEMISTRY, PHARMACEUTICAL; DIPHENYLHEXATRIENE; FLUORESCENCE; FURANS; MICROSCOPY, ELECTRON, TRANSMISSION; PHYTOSTEROLS;

EID: 4744374202     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120039509     Document Type: Article

References (6)

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2. Wasan, K.; Najafi, S.; Wong, J.; Kwong, M.; Pritchard, P.H. Assessing plasma lipid levels, body weight, and hepatic and renal toxicity following chronic oral administration of a water soluble phytostanol compound, FM-VP4, to gerbils. J. Pharm. Pharm. Sci. 2001, 4, 228-234.
3. Wasan, K.M.; Najafi, S.; Peteherych, K.D.; Prichard, P.H. Effects of a novel hydrophilic phytostanol analog on plasma lipid concentrations in gerbils. J. Pharm. Sci. 2001, 90, 1795-1799.
4. Zhang, X.; Jackson, J.K.; Burt, H.M. Determination of surfactant critical micelle concentration by a novel fluorescence depolarization technique. J. Biochem. Biophys. Methods 1996, 31, 145-150.
5. Chattopadhyaa, A.; London, E. Fluorimetric determination of critical micelle concentration avoiding interference from detergent charge. Anal. Biochem. 1984, 139, 408-412.
6. Ramaswamy, M.; Yau, E.; Wasan, K.M.; Boulanger, K.D.; Li, M.; Pritchard, P.H. Influence of a novel hydrophilic phytostanol compound, FM-VP4, on pancreatic lipase activity and cholesterol accumulation within Caco-2 cells. J. Pharm. Pharm. Sci. 2002, 5, 29-38.