Phenylalanine kinetics differ between formula-fed and human milk-fed preterm infants

Journal of Nutrition

Volumn 134, Issue 10, 2004, Pages 2540-2545

  Darling, Pauline B ^a,b   Dunn, Michael ^b,c   Gilani, G Sarwar ^d   Ball, Ronald O ^b,e   Pencharz, Paul B ^a,b  

^a HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c WOMEN S COLLEGE HOSPITAL   (Canada)

^d Bureau of Nutritional Sciences   (Canada)

^e UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Breast milk; Infant formula; Phenylalanine kinetics; Preterm infants; Tyrosine

Indexed keywords

CASEIN; ESSENTIAL AMINO ACID; PHENYLALANINE; THREONINE; TYROSINE;

AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; ARTIFICIAL MILK; BREAST MILK; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IN VIVO STUDY; MALE; NEWBORN; OXIDATION; PREMATURITY; PROTEIN INTAKE; WHEY;

EID: 4744373267     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/134.10.2540     Document Type: Article

References (31)

1. American Academy of Pediatrics, Committee on Nutrition (1985) Nutritional needs for low birthweight infants. Pediatrics 75: 976-986.
2. Canadian Paediatric Society, Nutrition Committee (1995) Nutrient needs and feeding of premature infants. Can. Med. Assoc. J. 152: 1765-1785.
3. European Society of Paediatric Gastroenterology and Nutrition (ESP-GAN), Committee on Nutrition (1987) Nutrition and feeding of preterm infants. Acta Paediatr. Scand. Suppl. 336: 3-14.
4. Raiha, N.C.R. (1974) Biochemical basis for nutritional management of preterm infants. Pediatrics 53: 147-156.
5. FAO/WHO Expert Consultation (1990) Protein quality evaluation, Rome: (FAO) Food and Agriculture Organization of the United Nations.
6. Hambraeus, L. (1977) Proprietary milk versus human breast milk in infant feeding. Pediatr. Clin. North Am. 24: 17-36.
7. Kunz, C. & Lonnerdal, B. (1992) Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatr. 81: 107-112.
8. Darling, P. B., Dunn, M., Sarwar, G. G., Brookes, S., Ball, R. O. & Pencharz, P. B. (1999) Threonine kinetics in preterm infants fed their mother's milk or formula with varying whey: casein ratios. Am. J. Clin. Nutr. 69: 105-114.
9. George, D. E. & DeFrancesca, B. A. (1989) Human milk in comparison to cow milk. In: Textbook of Gastroenterology and Nutrition in Infancy (Lebenthal, E., ed.), pp. 239-261. Raven Press: New York, NY.
10. Picone, T. A., Benson, J. D., MacLean, W. C. & Sauls, H. S. (1989) Amino acid metabolism in human milk-fed and formula-fed term infants. In: Protein and Non-protein Nitrogen in Human Milk (Atkinson, S. A. & Lonnerdal, B., eds.), pp. 173-186. CRC Press: Boca Raton, FL.
11. Pencharz, P. B., Farri, L. & Papageorgiou, A. (1983) The effects of human milk and low-protein formulae on the rates of total body protein turnover and urinary 3-methyl-histidine excretion of preterm infants. Clin. Sci. 64: 611-616.
12. Jarvenpaa, A.-L., Rassin, D. K., Raiha, N.C.R. & Gaull, G. E. (1982) Milk protein quantity and quality in the term infant: II. Effects on acidic and neutral amino acids. Pediatrics 70: 221-230.
13. Janas, L. M., Picciano, M. F. & Hatch, T. F. (1985) Indices of protein metabolism in term infants fed human milk, whey-dominant formula, or cow's milk formula. Pediatrics 75: 775-784.
14. Janas, L. M., Picciano, M. F. & Hatch, T. F. (1987) Indices of protein metabolism in term infants fed either human milk or formulas with reduced protein concentration and various whey/casein ratios. J. Pediatr. 110: 838-848.
15. Kashyap, S., Okamoto, E., Kanaya, S., Zucker, C., Abildskov, K., Dell, R. B. & Heird, W. C. (1987) Protein quality in feeding low birth weight infants: a comparison of whey-predominant versus casein-predominant formulas. Pediatrics 79: 748-755.
16. Priolisi, A., Didato, M., Gioli, R., Fazzolari-Nesci, A. & Raiha, N.C.R. (1992) Milk protein quality in low birth weight infants: effects of protein-fortified human milk and formulas with three different whey-to-casein ratios on growth and plasma amino acid profiles. J. Pediatr. Gastroenterol. Nutr. 14: 450-455.
17. Dubowitz, L., Dubowitz, V. & Goldberg, C. (1970) Clinical assessment of gestational age of the newborn infant. J. Pediatr. 77: 1-10.
18. Usher, R. & McLean, F. (1969) Intrauterine growth of live Caucasian infants at sea level: Standards obtained from measurement in seven dimensions of infants born between 25 and 44 weeks of gestation. J. Pediatr. 74: 901-910.
19. Wykes, L. J., Ball, R. O., Menendez, C. E., Ginther, D. M. & Pencharz, P. B. (1992) Glycine, leucine and phenylalanine flux in low-birth-weight infants during parenteral and enteral feeding. Am. J. Clin. Nutr. 55: 971-975.
20. Zello, G. A., Menendez, C. E., Rafii, M., Clarke, R., Wykes, L. J., Ball, R. O. & Pencharz, P. B. (2003) Protein kinetics in the preterm neonate studied at differing short-term protein intakes using various stable amino acid isotopic tracers. Pediatr. Res. 53: 338-344.
21. 13C]amino acids. Metabolism 48: 732-737.
22. 13C]KIC in plasma by capillary gas chromatography/mass spectrometry in protein turnover studies. Biomed. Mass Spectrom. 12: 432-436.
23. Sarwar, G., Botting, H. G. & Peace, R. W. (1988) Complete amino acid analysis in hydrolysates of foods and feces by liquid chromatography of precolumn phenylisothiocyanate derivatives. J. Assoc. Off. Anal. Chem. 71:1172-1175.
24. Munro, H. N. & Fleck, A. (1969) Analysis of tissue and body fluids for nitrogenous constituents. In: Mammalian Protein Metabolism (Munro, H. N., Ed.), pp. 424-425. Academic Press: New York, NY.
25. Matthews, D. E., Motil, K. J., Rohrbaugh, D. K., Burke, J. F., Young, V. R. & Bier, D. M. (1980) Measurement of leucine metabolism in man from a primed, continuous infusion of L-[1-13C]leucine. Am. J. Physiol. 239: E473-E479.
26. Cooke, R. J., Watson, D., Workman, S. & Conner, C. (1992) Effects of type of dietary protein on acid-base status, protein nutritional status, plasma levels of amino acids, and nutrient balance in the very low birthweight infant. J. Pediatr. 121: 444-451.
27. House, J. D., Pencharz, P. B. & Ball, R. O. (1997) Phenylalanine kinetics and requirements determined using I-[14C] - Phenylalanine in neonatal piglets receiving total parenteral nutrition supplemented with tyrosine. Am. J. Clin. Nutr. 65: 984-993.
28. Van Toledo-Eppinga, L., Kalhan, S. C., Kulik, W., Jakobs, C. & Lafeber, H. N. (1996) Relative kinetics of phenylalanine and leucine in low birth weight infants during nutrient administration. Pediatr. Res. 40: 41-46.
29. Lucas, A., Boyes, S., Bloom, S. R. & Aynsley-Green, A. (1981) Metabolic and endocrine responses to a milk feed in six-day-old term infants: differences between breast and cow's milk formula feeding. Acta Paediatr. Scand. 70: 195-200.
30. Salmenpera, L., Perheentupa, J., Slimes, M. A., Adrian, T. E., Bloom, S. R. & Aynsley-Green, A. (1988) Effects of feeding regimen on blood glucose levels and plasma concentrations of pancreatic hormones and gut regulatory peptides at 9 months of age: comparison between infants fed with milk formula and infants exclusively breast-fed from birth. J. Pediatr. Gastroenterol. Nutr. 7: 651-6.
31. Zello, G. A., Pencharz, P. B. & Ball, R. O. (1990) Phenylalanine flux, oxidation and conversion to tyrosine in humans studied with L-(1-13C)-phenylalanine. Am. J. Physiol. 259: E835-E843.