Long hydrocarbon chain ether diols and ether diacids that favorably alter lipid disorders in vivo

Journal of Medicinal Chemistry

Volumn 47, Issue 21, 2004, Pages 5183-5197

  Mueller, Ralf ^a   Yang, Jing ^a   Duan, Caiming ^a   Pop, Emil ^a   Lian, Hao Zhang ^a   Huang, Tian Bao ^a   Denisenko, Anna ^a   Denisko, Olga V ^a   Oniciu, Daniela C ^b   Bisgaier, Charles L ^b   Pape, Michael E ^b   Freiman, Catherine Delaney ^b   Goetz, Brian ^b   Cramer, Clay T ^b   Hopson, Krista L ^b   Dasseux, Jean Louis H ^b  

^a Alchem Laboratories Corporation   (United States)

^b Esperion Therapeutics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 [3 (2 CARBOXY 2 METHYLPROPYL)PHENOXY]PHENYL] 2,2 DIMETHYLPROPIONIC ACID; 3 [3 [3 (3 HYDROXY 2,2 DIMETHYLPROPYL)PHENOXY]PHENYL] 2,2 DIMETHYLPROPAN 1 OL; 4 [3 (4 CARBOXY 3 METHYLBUTOXY)PROPOXY] 2,2 DIMETHYLBUTYRIC ACID; 5 (5 HYDROXY 4 METHYL 4 PHENYLPENTYLOXY) 2 METHYL 2 PHENYLPENTAN 1 OL; 5 [2 (4 CARBOXY 4 METHYLPENTYLOXY)ETHOXY] 2,2 DIMETHYLPENTANOIC ACID; 5 [2 (5 HYDROXY 4,4 DIMETHYLPENTYLOXY)ETHOXY] 2,2 DIMETHYLPENTAL 1 OL; 6 (5 HYDROXY 4 METHYL 4 PHENYLPENTYLOXY) 2 METHYL 2 PHENYLHEXAN 1 OL; 6 (6 HYDROXY 5 METHYL 5 PHENYLHEXYLOXY) 2 METHYL 2 PHENYLHEXAN 1 OL; 6 (6 HYDROXY 5,5 DIMETHYLHEXYLOXY) 2,2 DIMETHYLHEXAN 1 OL; 7 (7 HYDROXY 6,6 DIMETHYLHEPTYLOXY) 2,2 DIMETHYLHEPTAN 1 OL; ANTILIPEMIC AGENT; CHOLESTEROL; ETHER DERIVATIVE; FUNCTIONAL GROUP; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROCARBON; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; DYSLIPIDEMIA; FEMALE; GLUCOSE BLOOD LEVEL; HORNER REACTION; IN VIVO STUDY; LIPOGENESIS; LIVER CELL CULTURE; NONHUMAN; RAT; RAT STRAIN; STRUCTURE ACTIVITY RELATION; TRIACYLGLYCEROL BLOOD LEVEL; WILLIAMSON REACTION;

ANIMALS; ANTILIPEMIC AGENTS; CELLS, CULTURED; CHOLESTEROL, HDL; DICARBOXYLIC ACIDS; ETHERS; ETHERS, CYCLIC; FEMALE; HEPATOCYTES; HYDROCARBONS; LIPIDS; MALE; OBESITY; PHENYL ETHERS; RATS; RATS, SPRAGUE-DAWLEY; RATS, ZUCKER; STRUCTURE-ACTIVITY RELATIONSHIP; TRIGLYCERIDES;

EID: 4744364182     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0400395     Document Type: Article

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