Complex cytogenetics in a case of probably work related MDS/AML

Leukemia Research

Volumn 28, Issue 12, 2004, Pages 1357-1361

  Salamanchuk, Zoriana ^a   Jakóbczyk, Malgorzata ^a   Nowak, Wieslaw ^a   Skotnicki, Aleksander B ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

acute myeloid leukemia; AML; Ara C; BM; bone marrow; Complex karyotype; cytosine arabinoside; FISH; fluorescence in situ hybridization; Leukemogenic exposures; MDS; Multilineage dysplasia; myelodysplastic syndrome; SKY; spectral karyotyping

Indexed keywords

ALKYLATING AGENT; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOSTATIC AGENT; DAUNORUBICIN; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ETOPOSIDE; VINBLASTINE; VINCRISTINE;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGRANULOCYTOSIS; ARTICLE; BONE MARROW BIOPSY; CANCER CHEMOTHERAPY; CASE REPORT; CHROMOSOME; CYTOGENETICS; FAMILY HISTORY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; HUMAN; LABORATORY TEST; LEUKEMOGENESIS; MYELODYSPLASTIC SYNDROME; OCCUPATIONAL EXPOSURE; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SPECTRAL KARYOTYPING; WORK;

ACUTE DISEASE; ALKYLATING AGENTS; ANTINEOPLASTIC AGENTS; BONE MARROW EXAMINATION; CYTOGENETIC ANALYSIS; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; FEMALE; GENE DUPLICATION; GENE REARRANGEMENT; HUMANS; LEUKEMIA, MYELOID; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; OCCUPATIONAL EXPOSURE;

EID: 4744349914     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2004.04.005     Document Type: Article

References (15)

1. Greenberg P., Cox C., LeBeau M.M., Fenaux P., Morel P., et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 89:1997;2079-2088
2. Nisse C., Haguenoer L.M., Grandbastein B., Preudhomme C., Fontaine B., et al. Occupational and environmental risk factors of the myelodysplastic syndromes in the north of France. Br J Haematol. 112:2001;927-935
3. Skov T., Maarup B., Olsen J., Rorth M., Winthereik H., et al. Leukemia end reproductive outcome among nurses handling antineoplastic drugs. Br J Ind. Med. 49:1992;855-861
4. McLaughlin J.K. Formaldehyde and cancer: a critical review. Inter Arch. Occup. Health. 66:1994;295-301
5. Pedersen-Bjergaard J., Andersen M.K., Christiansen D.H., Nerlov K. Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. Blood. 99:2002;1909-1912
6. Vardiman J.W., Harris N.L., Brunning R.D. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 100:2002;2292-2302
7. Mitelman F, editor. ISCN: an international system for human cytogenetic nomenclature, Basel: S. Karger, 1995.
8. Kakazu N., Taniwaki M., Horiike S., Nishida K., Tatekawa T., et al. Combined spectral karyotyping and DAPI banding analysis of chromosome abnormalities in myelodysplastic syndrome. Genes Chromosomes Cancer. 26:1999;336-345
9. Mrozek K., Heinonen K Theil K.S., Bloomfield C.D. Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q. Genes Chromosomes Cancer. 34:2002;137-153
10. Pedersen-Bjergaard J., Pedersen M., Roulston D., Philip P. Different genetic pathways in leukemogenesis for patients presenting with therapy-related myelodysplasia and therapy-related acute myeloid leukemia. Blood. 86:1995;3542-3552
11. Pedersen-Bjergaard J., Philip P. Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II. Blood. 78:1991;1147-1148
12. Larson R.A., Le Beau M.M., Ratain M.J., Rowley J.D. Balanced translocations involving chromosome bands 11q23 and 21q22 in therapy-related leukemia. Blood. 79:1992;1892-1893
13. Dolan M., McGlennen R.C., Hirsch B. MLL amplification in myeloid malignancies: clinical, molecular, and cytogenetic findings. Cancer Genet Cytogenet. 134:2002;93-101
14. Andersen M.K., Christiansen D.H., Kirchhoff M., Pedersen-Bjergaard J. Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapy-related MDS and AML, and is closely related to mutation of TP53 gene and to previous therapy with alkylating agents. Genes Chromosomes Cancer. 31:2001;33-41
15. Van Limbergen H., Poppe B., Michaux L., Herens C., Brown J., et al. Identification of cytogenetic subclasses and recurring chromosomal aberrations in AML and MDS with complex karyotypes using M-FISH. Genes Chromosomes Cancer. 33:2002;60-72