Herbal remedies for menopausal symptoms: Are we cautious enough?

European Journal of Contraception and Reproductive Health Care

Volumn 13, Issue 2, 2008, Pages 133-137

  Haimov Kochman, Ronit ^a   Brzezinski, Amnon ^a   Hochner Celnikier, Drorith ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Hazards; Herbal remedies; Hormone replacement therapy; Menopause; Phyto oestrogens; Safety; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANGELICA SINENSIS EXTRACT; CIMICIFUGA RACEMOSA EXTRACT; DAIDZEIN; DIGOXIN; GENISTEIN; GINSENG EXTRACT; GLUCOSE 6 PHOSPHATASE; ISOFLAVONE DERIVATIVE; PHENELZINE; PLACEBO; RALOXIFENE; SOYBEAN PROTEIN; TAMOXIFEN; WARFARIN;

ADJUVANT THERAPY; ANGELICA SINENSIS; ARTHRALGIA; ARTICLE; BLEEDING; BLEEDING TENDENCY; BLOOD CLOTTING DISORDER; BLOOD PRESSURE FLUCTUATION; BREAST CANCER; CIMICIFUGA RACEMOSA; CLINICAL TRIAL; DEPRESSION; DIARRHEA; DRUG MEGADOSE; DRUG SAFETY; FEVER; FLATULENCE; GASTROINTESTINAL SYMPTOM; GINSENG; HEADACHE; HERBAL MEDICINE; HOT FLUSH; HUMAN; HYPERINSULINEMIA; HYPOGLYCEMIA; INSOMNIA; INTRAHEPATIC CHOLESTASIS; MANIA; MEDICINAL PLANT; MENOPAUSAL SYNDROME; NAUSEA; PANAX SCHINSENG; PHOTOSENSITIVITY; PHYTOTHERAPY; PRACTICE GUIDELINE; PRESCRIPTION; PRIORITY JOURNAL; PROTHROMBIN TIME; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RASH; SIDE EFFECT; SLEEP DISORDER; SOYBEAN; THROMBOCYTE AGGREGATION; TREMOR;

CLIMACTERIC; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; PHYTOESTROGENS; PHYTOTHERAPY; PLANT PREPARATIONS; SAFETY; VITAMIN E;

EID: 47349127374     PISSN: 13625187     EISSN: 14730782     Source Type: Journal    
DOI: 10.1080/13625180801920131     Document Type: Article

References (25)

1. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-33.
2. Dietary Supplement Health and Education Act of 1994. S.784.
3. Krasuski RA, Michaelis K, Eckart RE. The cardiovascular patient's perceptions of complementary and alternative medicine. Clin Cardiol 2006;29:161-4.
4. Haimov-Kochman R, Hochner-Celnikier D. Hot flashes revisited: pharmacological and herbal options for hot flashes management. What does the evidence tell us? Acta Obstet Gynecol Scand 2005;84:972-9.
5. North American Menopause Society. Treatment of menopause-associated vasomotor symptoms: Position statement of The North American Menopause Society. Menopause 2004;11:11-33.
6. Kronenberg F. Hot flashes. In Lobo RA, ed. Treatment of the postmenopausal woman. Basic and clinical aspects. Philadelphia: Lippincott Williams & Wilkins 1999: 157-77.
7. Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 1998;139:4252-63.
8. This P, De La Rochefordiere A, Clough K, and the Breast Cancer Group of the Institut Curie. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34.
9. Limer JL, Speirs V. Phyto-oestrogens and breast cancer chemoprevention. Breast Cancer Res 2004;6:119-27.
10. Liske E. Therapeutic efficacy and safety of Cimicifuga racemosa for gynecologic disorders. Adv Ther 1998;15:45-53.
11. Mahady GB. Is black cohosh estrogenic? Nutr Rev 2003;61:183-6.
12. Lupu R, Mehmi I, Atlas E, et al. Black cohosh, a menopausal remedy, does not have estrogenic activity and does not promote breast cancer cell growth. Int J Oncol 2003;23:1407-12.
13. Liske E, Hanggi W, Henneicke-von Zepelin HH, et al. Physiological investigation of a unique extract of black cohosh [Cimicifugae racemosae rhizoma]: A 6-month clinical study demonstrates no systemic estrogenic effect. J Womens Health Gend Based Med 2002;11:163-74.
14. Huntley A, Ernst E. A systematic review of the safety of black cohosh. Menopause 2003;10:58-64.
15. Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs and spices. Proc Soc Exper Biol Med 1998;217:369-78.
16. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-50.
17. Hirata JD, Swiersz LM, Zell B. Does dong quai have estrogenic effects in postmenopausal women? A doubleblind, placebo-controlled trial. Fertil Steril 1997;68:981-6.
18. Page RL II, Lawrence JD. Potentiation of warfarin by dong quai. Parmacotherapy 1999;19:870-6.
19. Wiklund IK, Mattsson LA, Lindgren R, Limoni C. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Swedish Alternative Medicine Group. Int J Clin Pharmacol Res 1999;19:89-99.
20. Ang-Lee MK, Moss J, Yuan CS. Herbal medicines and perioperative care. JAMA 2001;286:208-16.
21. Yuan CS, WeiG, Dey L, et al. American ginseng reduces warfarin's effect in healthy patients: A randomized, controlled trial. Ann Intern Med 2004;141:23-7.
22. Zhu M, Chan KW, Ng LS, et al. Possible influences of ginseng on the pharmacokinetics and pharmacodynamics of warfarin in rats. J Pharm Pharmacol 1999;51:175-80.
23. Hu Z, Yang X, Ho PC, et al. Herb-drug interactions: A literature review. Drugs 2005;65:1239-82.
24. Barton DL, Loprinzi CL, Quella SK, et al. Prospective evaluation of vitamin E for hot flashes in breast cancer survivors. J Clin Oncol 1998;16:495-500.
25. Russell RB. Vitamin and trace mineral deficiency and excess. In Kasper DL, Braunwald E, Fauci AS, et al., eds. Harrison's Principles of internal medicine, 16th edn. New York: McGraw-Hill 2007:408-9.